ABSTRACT
BACKGROUND: Infections are a frequent cause of morbidity and mortality among postoperative liver transplant (OLT) patients and a leading cause of decompensated chronic liver disease (CLD) among patients awaiting the procedure. Oral lesions that are frequently observed in subjects with CLD may represent foci for systemic infections before and after OLT. AIMS: To evaluate the oral health profile of patients with CLD awaiting OLT. METHODS: One hundred thirty one patients including 100 males of overall mean age 49.5 ± 10.8 years with CLD were listed for OLT and examined for oral health status according to a established protocol. RESULTS: One hundred thirty (99%) patients were partially edentulous; 66 (51%) had chewing difficulties; and 63 (48%) experienced reduced salivary flow. With respect to periodontal disease and oral infections, 68 (25%) had periodontitis, 63 (48%) had periapical lesion, 64 (49%) had abscesses, and 59 (45%) had root fragments. Loss of follow-up was observed in 21 subjects. Among the 110 other patients, 63 (57%) underwent dental treatments with complications in only two cases. Interestingly, mortality was significantly lower among treated (31%) versus nontreated patient (79%; P<.001). CONCLUSIONS: Poor oral health status observed in most CLD patients may represent a source of systemic infections before and after OLT. Treatment of such lesions was feasible in the majority of the patients and seemed to be associated with a reduction in mortality.
Subject(s)
Liver Cirrhosis/surgery , Liver Transplantation , Mouth Diseases/complications , Oral Health , Waiting Lists , Adult , Brazil , Chi-Square Distribution , Female , Humans , Liver Cirrhosis/mortality , Male , Middle Aged , Mouth Diseases/diagnosis , Mouth Diseases/microbiology , Mouth Diseases/mortality , Mouth Diseases/therapy , Risk Assessment , Risk Factors , Waiting Lists/mortalityABSTRACT
A sample of children treated by phototherapy during the neonatal period has been studied in the population of Penne (South Eastern Italy) in order to confirm the association previously reported in newborns from the population of Rome between neonatal jaundice and phenotypes of adenosine deaminase (ADA) and acid phosphatase (ACP1). The present data confirm that the incidence of clinically relevant jaundice is much greater in newborns of phenotype ACP1 BA carrying ADA2 allele than in other infants. Since ACP1 probably acts as flavin mononucleotide phosphatase and is modulated by purine nucleotides, it is likely that enzymes of purine nucleotide metabolism (including ADA), ACP1 and flavoenzymes (including gluthatione reductase and enzymes of Krebs cycle), may represent a polygenic complex influencing bilirubin levels in the first few days of life.
Subject(s)
Acid Phosphatase/genetics , Adenosine Deaminase/genetics , Jaundice, Neonatal/enzymology , Nucleoside Deaminases/genetics , Female , Humans , Infant, Newborn , Italy , Jaundice, Neonatal/genetics , Jaundice, Neonatal/therapy , Male , Phenotype , Phototherapy , Polymorphism, GeneticABSTRACT
Os autores estudam 5 criancas de uma familia, portadoras de ataxia-telangiectasia, uma das quais com a doenca em sua expressao completa. Sao ressaltados os aspectos clinicos. As anormalidades geneticas, imunologicas e a avaliacao psicologica, sao comentadas
