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Bioorg Med Chem Lett
; 18(14): 3895-8, 2008 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-18590959
ABSTRACT
The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA(4)-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.