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1.
Clin Orthop Relat Res ; (333): 27-40, 1996 Dec.
Article in English | MEDLINE | ID: mdl-8981880

ABSTRACT

In 1079 consecutive patients undergoing total hip arthroplasty between 1984 and 1992, complications of thromboembolic disease and related anticoagulation were reviewed for 6 months after hospital discharge, including cost data. Of 347 patients having venograms, 78 (22.5%) had positive results and 269 (77.5%) had negative results for deep venous thrombosis. In patients with negative venograms, 3 (1.1%) were readmitted with 2 symptomatic deep venous thromboses and nonfatal pulmonary embolism. There were no readmissions among the 55 patients who had venographically evident deep venous thrombosis diagnosed and treated with outpatient warfarin. Overall, 3 of 324 (0.9%) patients with true positive or negative venograms were readmitted for complications of thromboembolic disease. In contrast, 12 of 732 (1.6%) patients not receiving contrast venography were readmitted, including 9 (1.2%) deep venous thromboses and 3 (0.4%) nonfatal pulmonary embolisms. Four of 23 patients (17.4%) with untreated calf deep venous thrombosis suffered 2 nonfatal pulmonary embolisms resulting in readmission and 2 fatal pulmonary embolisms outside the hospital. Untreated calf deep venous thrombosis after total hip arthroplasty represents a significant threat of extension to more proximal veins and distant embolization. Routine thromboembolic disease prophylaxis combined with screening contrast venography and selective therapeutic anticoagulation is effective in preventing late thromboembolic disease complications and, compared with a strategy of extended prophylaxis for all, is cost effective management by reducing exposure of the elderly population to outpatient anticoagulant therapy.


Subject(s)
Hip Prosthesis , Postoperative Complications/prevention & control , Thromboembolism/prevention & control , Aged , Costs and Cost Analysis , Humans , Middle Aged , Phlebography/economics , Postoperative Complications/diagnostic imaging , Postoperative Complications/economics , Postoperative Complications/etiology , Thromboembolism/diagnostic imaging , Thromboembolism/economics , Thromboembolism/etiology , Thrombolytic Therapy , Time Factors
2.
Am J Med ; 101(3): 309-15, 1996 Sep.
Article in English | MEDLINE | ID: mdl-8873493

ABSTRACT

The mission, indeed the very existence, of the traditional academic health center is under siege. Changes in the financing and delivery of health care threaten the clinical revenue used to subsidize the tripartite mission of education, research, and patient care. Market practices, driven by the growth of managed care, will intensify the impact of declining revenue to threaten the actual patient base necessary to sustain these endeavors. The survival of academic health centers depends on their ability to change. This change will not be easy, and the size of the collective academic medical establishment will decrease. Successful enterprises will be those that go beyond incremental, reactive adjustments. Nothing short of organizational redesign, creation of strategic partnerships, and adopting a cybernetic model of continuous measurement, improvement and adaptability will suffice. Using the elements of a strategic planning exercise, this paper reviews the background issues that have produced the current predicament and explores the strengths and weaknesses inherent in academic institutions. Elements of an "idealized" academic health center are postulated and, finally, specific strategies that might be considered in creating a relevant and secure future are proposed.


Subject(s)
Academic Medical Centers/organization & administration , Academic Medical Centers/economics , Academic Medical Centers/trends , Forecasting , Organizational Objectives , United States
4.
Health Care Manag ; 1(1): 115-23, 1994 Aug.
Article in English | MEDLINE | ID: mdl-10152347

ABSTRACT

Controlling health care costs should allow the nation to provide more health services and higher quality care to more people. The authors are concerned, however, that many of the reform efforts will unwittingly undermine the culture of care in their pursuit of savings and access. This article is a plea to maintain the core moral values and the social and institutional commitments that are essential in the delivery of care, so that the health care community is not turned into a health industry. The authors' communitarian approach aims to preserve the balance between individual rights and social responsibilities, the moral integrity of a caring society, and the unique character of mutual trust between patients and health care personnel. They advocate an orientation toward preventing disease and promoting health, an imperative of reforming the violent, reckless, and costly aspects of American society, and a moral justification for cutting administrative waste, defensive medicine, and excessive profits rather than rationing beneficial and humane health services.


Subject(s)
Health Care Reform/standards , Social Responsibility , Social Values , Child , Evaluation Studies as Topic , Health Care Reform/legislation & jurisprudence , Humans , Managed Competition/standards , Morals , Quality of Health Care , United States
5.
J Bone Joint Surg Br ; 74(6): 814-21, 1992 Nov.
Article in English | MEDLINE | ID: mdl-1447240

ABSTRACT

We implanted 57 uncemented cobalt-chrome porous-coated collarless femoral components into 51 patients (mean age 49 years). At review, five to eight years postoperatively, good or excellent results were recorded in 70% by the Mayo Clinic hip evaluation and in 84% by the Harris hip score. Revision for aseptic loosening of the femoral stem was necessary in only one hip. Thigh pain diminished with time and was present in only two hips at the time of review. Endosteal bone formation was seen at the junction of the smooth and the porous segments of the stem in 94% of hips and in 60% it continued after three years. In 90% of hips, proximal femoral atrophy did not progress after three years. Discontinuous radiolucent lines were seen around 30% of stems, most commonly in zones I, IV and VII. They were not progressive in 94% and their presence did not correlate with the clinical outcome.


Subject(s)
Hip Prosthesis , Activities of Daily Living , Adult , Aged , Chromium Alloys , Female , Femur/diagnostic imaging , Femur/surgery , Follow-Up Studies , Humans , Male , Middle Aged , Prosthesis Design , Radiography , Reoperation , Surveys and Questionnaires
6.
Semin Arthroplasty ; 3(3): 156-66, 1992 Jul.
Article in English | MEDLINE | ID: mdl-10147774

ABSTRACT

Differentiation of pluripotential stem cells into osteogenic precursors is exquisitely sensitive to ionizing radiation. Radiation prophylaxis effectively prevents ectopic ossification if delivered to the operative site within 5 days following total hip arthroplasty. Continued efforts at dose reduction over the last decade have demonstrated efficacy with as little as 6,000 to 8,000 rad; no soft tissue sarcomas have been reported in this low dose range following treatment of malignant disease. Precise limitation of the treatment field is necessary for application of this modality to cementless implants dependent on bony ingrowth for stable fixation. Trochanteric nonunion is reported in 25% of hips following radiation prophylaxis, but this is as likely related to the high proportion of revision surgery in these series as it is a direct consequence of the radiation.


Subject(s)
Hip Prosthesis/adverse effects , Neoplasms, Radiation-Induced/prevention & control , Ossification, Heterotopic/prevention & control , Postoperative Complications/prevention & control , Animals , Hip Prosthesis/methods , Humans , Ossification, Heterotopic/physiopathology , Ossification, Heterotopic/radiotherapy , Postoperative Care/methods , Postoperative Complications/radiotherapy , Risk Factors
7.
J Bone Joint Surg Am ; 74(2): 186-200, 1992 Feb.
Article in English | MEDLINE | ID: mdl-1541613

ABSTRACT

Sixty-two hips in fifty-five patients who were considered to be at risk for postoperative heterotopic ossification were randomly divided into two groups: one received a single 800-centigray dose of limited-field radiation and the other, 1000 centigray of limited-field radiation in divided doses. The risk for heterotopic-bone formation was identified on the basis of previously described criteria, which included previous heterotopic ossification after an operation about the hip, hypertrophic osteoarthritis or post-traumatic osteoarthrosis characterized by formation of extensive osteophytes, radiographic evidence of diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, and male sex. The treatment portals excluded prosthetic surfaces that were intended for biological fixation by ingrowth of bone. At a minimum six-month follow-up, progression of heterotopic ossification had occurred in seven (21 per cent) of thirty-four hips in the first group and in six (21 per cent) of twenty-eight hips in the second group. The ossification had advanced more than one grade in only one hip. Extra-field ossification occurred in fifteen (43 per cent) of thirty-five hips that had not had previous heterotopic ossification. Since the time of the study, the treatment portal has been modified to include the lateral aspect of the greater trochanter, so that the risk of bursitis associated with ossification in this area is minimized. Single-dose limited-field radiation is effective for the prevention of heterotopic ossification, without compromise of early fixation of an uncemented implant.


Subject(s)
Hip Joint/radiation effects , Hip Prosthesis , Ossification, Heterotopic/prevention & control , Postoperative Complications/prevention & control , Adult , Aged , Aged, 80 and over , Female , Hip Joint/diagnostic imaging , Humans , Male , Middle Aged , Ossification, Heterotopic/diagnostic imaging , Ossification, Heterotopic/etiology , Ossification, Heterotopic/radiotherapy , Postoperative Care , Prospective Studies , Radiography , Radiotherapy Dosage
8.
Clin Orthop Relat Res ; (263): 87-93, 1991 Feb.
Article in English | MEDLINE | ID: mdl-1899641

ABSTRACT

Heterotopic ossification (HO) is a frequent occurrence after cemented and cementless total hip arthroplasty (THA). Patients at risk for this complication include those with preexisting ipsilateral or contralateral HO, diffuse idiopathic skeletal hyperostosis, hypertrophic osteoarthrosis, posttraumatic arthritis, and ankylosing spondylitis. Low-dose radiation therapy effectively prevents HO in this high-risk group when treatment is begun early in the postoperative period. A prospective evaluation has established the efficacy of fractionated and single-dose radiation therapy protocols. Limited radiation portals are used in patients receiving cementless prostheses. A rectangular radiation portal obliquely oriented to the prosthesis enables radiation treatment of the periarticular soft tissues while avoiding exposure of the bone-prosthesis interface. Radiation therapy to this interface may inhibit or delay bony ingrowth. Radiation therapy is the only treatment used to prevent HO that is delivered locally and not systemically. Low-dose radiation therapy using a limited radiation portal is the treatment of choice to prevent HO in high-risk patients after cementless THA.


Subject(s)
Hip Prosthesis , Ossification, Heterotopic/radiotherapy , Postoperative Complications/radiotherapy , Humans , Ossification, Heterotopic/prevention & control , Postoperative Complications/prevention & control , Radiotherapy Dosage , Risk Factors
10.
Int J Radiat Oncol Biol Phys ; 18(5): 1139-42, 1990 May.
Article in English | MEDLINE | ID: mdl-2112120

ABSTRACT

Radiation therapy has been shown to prevent heterotopic bone formation in high risk patients undergoing total hip replacement. A number of doses have been used without a randomized trial comparing one dose regimen against another. A prospective randomized trial was undertaken comparing 10 Gy in 5 fractions versus 8 Gy in 1 fraction. Forty-seven patients have been randomized at the time of this evaluation with 37 patients eligible for analysis. The pre-operative, immediate post-operative and 2 month post-operative radiographs were graded. At the time of this analysis, 17 patients were randomized to the 8 Gy arm with 20 patients in the 10 Gy arm. Patients were treated with limited fields so as to only cover the area at risk for development of heterotopic bone to prevent adverse effects on biologic fixation of uncemented implants. When comparing the pre-operative, operative, and 2 month post-operative radiographs, only four patients (1 patient in the 8 Gy arm and 3 patients in the 10 Gy arm), had an increase in the score. No patient had an increase in score to a clinically significant level, usually grade 3 or 4. These preliminary results appear to show that 8 Gy in a single fraction can be as effective as 10 Gy in 5 fractions in preventing heterotopic bone in susceptible individuals. Further follow-up of the remaining patients may confirm this.


Subject(s)
Hip Joint/radiation effects , Hip Prosthesis/adverse effects , Ossification, Heterotopic/prevention & control , Female , Hip Joint/diagnostic imaging , Humans , Male , Ossification, Heterotopic/etiology , Radiography , Radiotherapy Dosage , Randomized Controlled Trials as Topic
11.
Int J Radiat Oncol Biol Phys ; 18(4): 861-5, 1990 Apr.
Article in English | MEDLINE | ID: mdl-2323973

ABSTRACT

Radiation has been shown to be effective in the prevention of heterotopic bone. The exact etiology of heterotopic bone is unknown. Total Hip prosthetic devices that do not depend upon bone cement for fixation have become increasingly popular. The mechanism by which the bone forms around the prosthesis is similar to the process by which fractures heal which has been shown to be sensitive to irradiation. Using a rabbit model we have undertaken a study to investigate the effect of irradiation on the bony ingrowth on porous coated implants. Forty-five rabbits had porous coated implants surgically placed in the tibiae bilaterally. Each rabbit had one tibae randomly irradiated with 1,000 cGy in 5 fractions starting on the first post-operative day. Animals were sacrificed weekly starting 2 weeks post-operatively and the tibae were sent for pullout studies. The amount of force necessary to pullout the treated tibae was statistically less than the amount of force necessary to remove the untreated tibae at 2 weeks. From 3 weeks on there was no difference in the force necessary to remove the prosthesis from the untreated or treated tibae. Histologically, the untreated tibae showed bone formation while the treated tibae did not. Because of these results, it is suggested that the treatment of patients at risk for development of heterotopic bone be modified to only include the area between the femur and pelvis avoiding treatment of the prosthetic device.


Subject(s)
Bone Neoplasms/prevention & control , Bone and Bones , Choristoma/prevention & control , Tibia/radiation effects , Animals , Bone Neoplasms/etiology , Choristoma/etiology , Female , Prosthesis Design , Rabbits
12.
Clin Orthop Relat Res ; (252): 252-61, 1990 Mar.
Article in English | MEDLINE | ID: mdl-1967997

ABSTRACT

In 1979, coincident with a planned decrease in the size of the general surgery training program, the orthopedic department of the senior author's university-affiliated teaching hospital began to employ physician assistants. The intent of using physician assistants was to relieve the two orthopedic residents assigned to the hospital of many service responsibilities and patient care that previously had been rendered by the general surgical residents and interns. The non-M.D. physician assistants record a comprehensive past and present medical history, carry out physical exams, and assist at surgery. They are directly under the supervision of and responsible to the attending surgeon. It was hoped the addition of these individuals will help maintain a quality educational experience for the orthopedic residents. The general response to the use of physician assistants in this affiliated hospital has been favorable.


Subject(s)
Hospital Departments , Internship and Residency , Orthopedics , Physician Assistants/statistics & numerical data , Hospital Bed Capacity, 300 to 499 , Hospitals, Community , Humans , New York , Operating Room Technicians , Orthopedics/education , Program Evaluation , Workforce
14.
Clin Orthop Relat Res ; (232): 271-8, 1988 Jul.
Article in English | MEDLINE | ID: mdl-3383492

ABSTRACT

The long-term clinical and physiological sequelae of venographically diagnosed, asymptomatic postoperative venous thrombosis were studied in a group of 51 patients following total hip or total knee arthroplasty. After a mean follow-up period of 49.7 months, the patients were recalled for interview, physical examination, air plethysmography (APG), and photoplethysmography (PPG). At the time of follow-up examination, legs with prior postoperative venous thrombosis were not more likely to have clinical findings of deep venous insufficiency than legs with a negative venogram. Abnormal venous emptying, as measured by APG, was significantly correlated (p less than 0.005) with postoperative venous thrombosis and was found in patients with both proximal and calf vein thrombi, but was not clearly associated with symptoms. There was, however, a significant correlation (p less than 0.0005) between clinical findings of venous insufficiency and incompetent valves, as reflected by rapid refilling time after exercise shown by PPG. The findings indicate that asymptomatic postoperative venous thrombosis involving calf or proximal veins can lead to abnormal vein function, but is not closely correlated with later development of symptoms. These observations also suggest that symptomatic venous insufficiency is more closely associated with calf vein valve incompetence than with proximal vein obstruction.


Subject(s)
Hip Prosthesis , Knee Prosthesis , Postoperative Complications/physiopathology , Thrombosis/physiopathology , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Plethysmography , Radiography , Thrombosis/diagnostic imaging , Venous Insufficiency/physiopathology
15.
Clin Orthop Relat Res ; (222): 98-104, 1987 Sep.
Article in English | MEDLINE | ID: mdl-3304766

ABSTRACT

Pulmonary embolism is still the largest single cause of postoperative mortality (1%-3%) from major reconstructive lower extremity joint surgery. It is imperative that the surgeon who deals with trauma and musculoskeletal disorders be informed about the prevention of venous thromboembolic disease, recognize the magnitude of the problem, and then take effective steps. Attention must be given to the use of physical methods and the administration of effective antithrombotic agents, including anticoagulants and antiplatelet agents as well as combination agents, to prevent thromboembolic disease.


Subject(s)
Thrombophlebitis/prevention & control , Humans , Thrombophlebitis/etiology
16.
Int J Radiat Oncol Biol Phys ; 13(3): 365-9, 1987 Mar.
Article in English | MEDLINE | ID: mdl-3104246

ABSTRACT

Prior studies have demonstrated the effectiveness of postoperative radiation therapy (RT) to the hip area following total hip replacement (THR) surgery in preventing the development of heterotopic bone formation in patients considered to be at high risk for development of this complication. Previously, patients received 20.00 Gy in 10 fractions (fx) over 2 weeks, beginning as soon postop as medically feasible (usually post-op day 2). In an effort to reduce hospital stay and risk of secondary malignancy, a prospective treatment program was initiated April 1982 using a reduced dose of 10.00 Gy in 5 fx over 5-7 days. As of February 1984, 46 consecutive hips determined to be at high risk were treated with this reduced dose. Prior studies have demonstrated that heterotopic bone is always radiographically evident by 8 weeks. Of the 46 hips, 41 had been evaluated with the minimum required 8 week follow-up X ray. Twenty-five of these hips, 61%, had a mean long term follow-up of 12 months. Our historical control group, consisting of 54 consecutive high risk post-THR's, was shown to have a 68.5% incidence of heterotopic bone. The 20.00 Gy group, when RT was started by post-op day 5, demonstrated a 3.2% incidence, compared to 4.9% in the 10.00 Gy group. Complication rates were also comparable in the two RT groups, 19.4% and 7.3% respectively; 10.00 Gy is apparently as effective as 20.00 Gy in preventing heterotopic bone formation in high risk post-THR patients.


Subject(s)
Hip Prosthesis/adverse effects , Hip/radiation effects , Ossification, Heterotopic/prevention & control , Adult , Aged , Aged, 80 and over , Humans , Middle Aged , Ossification, Heterotopic/etiology , Radiotherapy Dosage
17.
Arthroscopy ; 3(3): 209-12, 1987.
Article in English | MEDLINE | ID: mdl-3675793
20.
J Bone Joint Surg Am ; 68(9): 1423-30, 1986 Dec.
Article in English | MEDLINE | ID: mdl-3097023

ABSTRACT

A prospective study was done to evaluate the efficacy of treatment with 1,000 rads of radiation in the prevention of heterotopic ossification after total hip arthroplasty in patients who are at high risk. In a previous prospective study, patients who were at high risk for heterotopic ossification after total hip arthroplasty were identified and an effective regimen for its prevention was established. It was demonstrated that treatment with 2,000 rads of radiation that was initiated within four days after the total hip arthroplasty was highly effective in the prevention of heterotopic ossification and in the prevention of recurrence after resection of existing ossification. In the present study, 1,000 rads of radiation was administered in increments of 200 rads over a period of five to seven days and was as effective as treatment with 2,000 rads. The protocol of 1,000 rads is preferable because it reduces the risk of malignancy and the duration of hospitalization.


Subject(s)
Choristoma/prevention & control , Hip Prosthesis/adverse effects , Ossification, Heterotopic/prevention & control , Postoperative Care/methods , Postoperative Complications/prevention & control , Aged , Aged, 80 and over , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/prevention & control , Choristoma/diagnostic imaging , Evaluation Studies as Topic , Female , Humans , Male , Middle Aged , Ossification, Heterotopic/diagnostic imaging , Postoperative Complications/diagnostic imaging , Radiography , Radiotherapy Dosage , Risk , Time Factors
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