[The efficacy of quinazopyrine, preparation E and riboxin in experimental myocardial infarct]. / Effektivnost' khinazopirina, preparata E i riboksina pri éksperimental'nom infarkte miokarda.

A study is presented of the carbohydrate energy metabolism and processes of peroxidation in rats with experimental pitutrin-isadrin myocardial infarction. Essential changes of these values were noted. It is concluded that quinasopyrin and preparation E normalize to a greater extent and riboxin to a smaller extent metabolic disorders in the ischemia-involved myocardium tissues.

[The mechanism of action of riboxin]. / K mekhanizmu deistviia riboksina.

The effect of riboxin (100 mg/kg body weight) on different kinds of metabolism in the cardiac muscles of Wistar rats in norm and during experimental pituitrin-neoepinephrine-induced myocardial infarction was studied. Riboxin was found to stimulate anaerobic glycolysis with the hyperproduction of lactate and the formation of glucose deficiency and also to increase the rate of protein synthesis on polyribosomes. Administration of riboxin during the formation of myocardial infarction considerably hinders the pronounced character of its electrocardiographic and biochemical manifestations. Thus, in the ischemic cardiac muscle the pool of macroergic phosphates is preserved, glycolysis and adaptive protein synthesis are impaired to a lesser degree that probably underlies the cardioprotective effect of riboxin.