ABSTRACT
Comparative evaluation of the incidence of the drug resistant pathogens at the patients with sepsis was performed. High ratio of the resistnt strain was shown and the most potent drugs were estimated. The investigation results demonstrates the necessity to improve diagnostic quality control. The data on drug susceptibility of the pathogens may be used for their taxonomic clarification.
Subject(s)
Drug Resistance, Bacterial , Emergency Service, Hospital , Sepsis/microbiology , Staphylococcal Infections/microbiology , Staphylococcus/drug effects , Staphylococcus/isolation & purification , Anti-Bacterial Agents/pharmacology , Humans , Quality Control , Sepsis/diagnosis , Staphylococcal Infections/diagnosis , Staphylococcus/classificationABSTRACT
The predominant pathogens at the emergency medicine hospital were analysed and its resistance to antibiotics was investigated in dynamics. The susceptibility of the pathogens was analysed by the method of dynamic equalibration. Statistically significant reduction of resistant bacteria isolation was demonstrated for 2 species of 7--that is S. aureus and E. faecalis regarding 4 antibiotics. The ratio of staphylococci resistant to cefazolin, ceftazidime, doxycyclin reduced, the ratio of enterococci resistant to chloramphenicol and doxycyclin also diminished. No correlation was demonstrated between the pathogen isolation frequency and ratio of resistant strains.
Subject(s)
Drug Resistance, Bacterial , Sepsis/microbiology , Bacterial Infections/epidemiology , Bacterial Infections/microbiology , Emergency Service, Hospital , Enterococcus faecalis/drug effects , Escherichia coli/drug effects , Humans , Klebsiella pneumoniae/drug effects , Proteus mirabilis/drug effects , Pseudomonas aeruginosa/drug effects , Staphylococcus aureus/drug effects , Streptococcus pyogenes/drug effects , SuppurationABSTRACT
The analysis of bacterial 16,530 strains, dynamically isolated from 6,157 patients with purulent septic processes (PSP) in surgical, traumatological, burn, toxicological and resuscitation departments, was made. The computer processing of data on the spread of the causative agents of PSP, depending on their taxonomic classification and drug resistance spectra, was carried out, which made in possible to obtain information on the outbreaks of hospital infections. Correlation of the number of PSP cases and the spread of hospital resistovars was analyzed. The data on the composition and drug resistance of pyogenic microorganisms could be used in the retrospective analysis of the epidemiological situation in a hospital. 3-year observations revealed the tendency to a decrease in the spread of the hospital variants of the causative agents of PSP, multiresistant to antibacterial preparations, which was indicative of the effectiveness of the antiepidemic measures carried out during this period.
Subject(s)
Bacteria/isolation & purification , Cross Infection/microbiology , Drug Resistance, Microbial , Bacteria/classification , Cross Infection/epidemiology , Databases, Factual , Disease Outbreaks , Humans , Retrospective Studies , Suppuration/epidemiology , Suppuration/microbiologyABSTRACT
The transition of bacilli to maintenance state in dialysis culture was revealed. The maintenance state is characterized by the lack of growth and spore formation. The experimental results are satisfactorily described by a modification of the synthetic chemostat model. As a results of model realization it was supposed that maintenance state of bacilli was connected with synthesis of autoinhibitor and initiation of spore formation.
