ABSTRACT
Cytochrome C (a single dose range of 1-200 mg/kg, intraperitoneally) does not possess the antihypoxic activity (altitude chamber, methemoglobinemia, circulatory hypoxia), decreases (in a dose of 50 mg/kg) diuresis in rats modifying diversely (depending on the dose used) the hypnotic effects of general anesthetics and the convulsant activity of corazol and arecoline.
Subject(s)
Cytochrome c Group/pharmacology , Animals , Brain Ischemia/drug therapy , Cytochrome c Group/therapeutic use , Diuresis/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug Interactions , Hypoxia/drug therapy , Mice , Rats , Seizures/chemically induced , Seizures/drug therapy , Sleep/drug effectsSubject(s)
Disulfiram/pharmacology , Acetaldehyde/metabolism , Alcohol Oxidoreductases/metabolism , Aldehyde Oxidoreductases/metabolism , Animals , Biotransformation , Catecholamines/biosynthesis , Catecholamines/metabolism , Cats , Disulfiram/metabolism , Ditiocarb/metabolism , Ditiocarb/pharmacology , Dogs , Dopamine beta-Hydroxylase/metabolism , Ethanol/metabolism , Humans , In Vitro Techniques , Mice , Rabbits , Rats , Serotonin/metabolism , Tyrosine 3-Monooxygenase/metabolism , Xanthine Oxidase/metabolismABSTRACT
Chemically pure dithiocarbamates, thiuramsulphides and ethylene-bis-dithiocarbamates display a well-marked antidiuretic action. They materially reduce diuresis, natri- and kaliuresis in rats (1/5 LD(50) per 1 kg into the stomach) and in dogs (sodium N, N-diethyl-dithiocarbamate-into renal artery). Without changing the tubular reabsorption DEDTC inhibits the glomerular filtration of the dogs' kidneys. Furosemide (lasix) prevents the development of the an antidiuletic anidiuretic effect and reduction of the sodium and potassium excretion provoked in rats with DEDTC, zinc N, N', N"-tetraethylthiuram-disulphide and ethylene-bis-dithiocarbamate. Furosemide is recommended for the treatment of acute poisonings with dithiocarbaminic acid derivatives.
