[Protein content in blood plasma and its changes in patients of the neurological critical care unit]. / Soderzhanie belkov v plazme krovi i ego dinamika u bol'nykh neiroreanimatsionnogo otdeleniia.

Twelve blood plasma proteins were studied in 120 patients with isolated traumatic and nontraumatic cerebral hemorrhage. At all stages of the study a marked imbalance of blood proteins occurred which was independent of the etiological factor. Patients with craniocerebral trauma exhibited the phenomenon of the atypical response manifesting with low concentration of acute-phase proteins. The levels of the complement component C5 and transferrin in patients with cerebral vascular aneurysm rupture are shown diagnostically significant while follow-up of blood transtiretin can show the trend in the metabolic processes in patients with cerebral hemorrhage in critical condition.

[Early evaluation of blood loss by the profile of blood proteins in patients with injuries]. / Ranniaia otsenka ob"ema krovopoteri po profiliu belkov plazmy krovi u bol'nykh s travmoi.

The concentrations of positive (C-reactive protein, orosomucoid, haptoglobin, ceruloplasmin) and negative (transtiretine, alpha 2-macroglobulin, transferrin) markers of acute phase response were measured in 55 victims with injuries to hollow organs on day 1 of hospitalization. By visual intraoperative evaluation of blood loss, the patients were divided in 2 groups: with blood loss under 1 liter (n = 32, group 1) and more than 1 liter (n = 23, group 2). Acute phase response was more manifest in group 1. Blood loss affected the levels of orosomucoid and haptoglobin, which is explained by functional characteristics of these blood proteins. Orosomucoid and haptoglobin tests were highly sensitive, specific, and accurate in evaluation of blood loss in patients with hollow organ wounds (87.5, 90, 89% and 80, 80, 80%, respectively). The content of these proteins equal to no more than 1 g/liter during the first day after the injury indicates blood loss higher than 1 liter with high probability.

[Homeostasis and its correction in burn patients with gastrointestinal erosive-ulcerative diseases]. / Sostoianie gomeostaza i ego korrektsiia u obozhzhennykh s érozivno-iazvennymi porazheniiami zheludochno-kishechnogo trakta.

Acute erosive ulcerative hemorrhage (EUH) is one of the most grave complications of burn disease, caused by impaired blood rheology, clotting, and protein status. Twenty-three patients with burns of 12-70% body surface were examined, 17-25% of burns being deep. The most pronounced changes in blood rheology and clotting with formation of erythrocyte aggregations, fibrin precipitation and imbalance of visceral proteins were observed during the shock stage (days 1-3), particularly pronounced in patients with acute EUH. Development of septicotoxemia favored secondary increase in blood clotting and rheological parameters, which led to thrombotic complications. The data helped improve the complex of infusion-transfusion therapy for preventing and treating ulcerative and erosive lesions.

[Acute phase response and plasma proteins in acute cholecystitis]. / Ostrofaznyi otvet i belki plasmy krovi pri ostrom kholetsistite.

Changes in the levels of plasma proteins albumin, transtiretine, transferrin, C-reactive protein, orosomucoid, and alpha 1-antitrypsin were followed up in patients with acute cholecystitis. Acute-phase response develops in acute cholecystitis; its development is most accurately characterized by the concentrations of C-reactive protein. The content of this protein together with the concentrations of transtiretine, orosomucoid, and alpha 1-antitrypsin can be regarded as an indicator of the severity of inflammation of the gallbladder and helps predict the disease course and define the terms of an intervention by the least invasive methods of treatment.

[Properties of intracellular virus-specific ribonucleoproteins containing negative and positive hepatitis A virus RNA]. / Svoistva vnutrikletochnykh virus-spetsificheskikh ribonukleoproteidov, soderzhashchikh negativnye i pozitivnye RNK virusagrippa A.

The characteristics of the intracellular virus-specific nucleocapsids containing either a negative or a positive RNA strand were studied. The immunosorption of nucleocapsids by the monoclonal antibodies against the three epitopes of NP protein failed to reveal any antigenic difference between the negative strand or positive strand-containing nucleocapsids. On the other hand, the sensitivity of virus-specific RNA in the nucleocapsids to digestion by the pancreatic ribonuclease proved to be lower for the positive strand-containing nucleocapsids.