[Metabolism of the sulphated glycosamino-glycans of skin, cartilage and bone of rats with adjuvant arthritis (author's transl)]. / Stoffwechsel der sulfatierten Glycosaminoglycane der Haut, des Knorpels und der Knochen von Ratten mit Adjuvans-Arthritis.

The time course of the quantitative changes in connective tissue of non-inflamed dorsal skin and of inflamed hind limbs was investigated by means of radioactively-labelled sulphate. Whereas the rate of incorporation of 35SO4 into the skin is reduced, its turnover in the inflamed tissue is greatly accelerated. This increase is observed both in the soft (cartilage) and hard (bone) connective tissue on both hind legs. The citric acid content of affected bone is lower than in healthy animals.

Influence of adjuvant arthritis on connective-tissue metabolism.

In rats with adjuvant arthritis, an analysis was made of the metabolism of sulfated proteoglycans, with particular attention to the dorsal skin and the extremities. Alterations were demonstrated in all the tissues examined. In the uninflamed dorsal skin, the uptake of exogenous sulfate was diminished. By contrast, in both hind limbs, at the injected and the non-injected site, the turnover of sulfated mucopolysaccharides was increased, above all in ligament and cartilage; the calcium content of the bone tissue of both hind legs was, however, not affected by the disease.

[New aspects of inflammation prevention by means of non-steroid antiphlogistics: the effect of Voltaren]. / Neue Aspekte der Entzündungshemmung durch nicht-steroide Antiphlogistika: Wirkung von Voltaren

Voltaren, a non-steroid antiinflammatory agent (NSA) of an entirely new chemical structure, is characterized by the high degree of antiinflammatory, antipyretic and analgesic activity it displays in animal experiments. Like other NSAs, the preparation inhibits prostaglandin synthesis, and various findings indicate that the spectrum of pharmacological activity of these agents is at least partly due to this inhibitory effect. Despite this common feature, however, there are quantitative and qualitative differences between Voltaren and other NSAs.