Different cardiorespiratory responses to hemorrhage and hyperoxia in normotensive (WKY) and spontaneously hypertensive (SHR) rats.

OBJECTIVE: To compare the cardiorespiratory responses underlying the beneficial effects of hyperoxia during blood loss between normotensive (WKY) and hypertensive (SHR) rats. METHODS: Experiments were carried out in anesthetized animals with both carotid bifurcations either innervated or denervated. The effects of breathing 60% O2 in N2 were studied either in combination with non-hypotensive hemorrhage or during hemorrhagic hypotension. RESULTS: In normoxia arterial pressure fell more in SHR than in WKY for a given blood loss. During hyperoxia, nerve-intact rats showed initial suppression of ventilation, but bifurcation-denervated rats a powerful enhancement. In all groups, hyperoxia increased the overall tone of venous capacitance vessels. CONCLUSIONS: The greater blood loss in SHR than in WKY when bleeding down to a given arterial pressure results from a stronger constriction of venous capacitance vessels. Hyperoxia improves the ability of the cardiorespiratory system to resist the effects of hemorrhage by increasing the overall venous tone, thus supporting cardiac filling, and in some cases also by increasing alveolar ventilation, probably secondary to improved cerebral oxygenation. The beneficial effects of hyperoxia were: (i) not prevented by carotid denervation, and thus were presumably direct tissue effects of oxygen, (ii) strikingly weaker in SHR than in normotensive (WKY) rats.

Reduced tolerance of simulated altitude (4200 m) in young men with borderline hypertension.

BACKGROUND: Primary hypertensives who are acutely exposed to hypoxic hypoxia show an enhanced reactivity of arterial chemoreceptors as well as an exaggerated response of the sympathetic nervous system. Since these phenomena could influence their ability to tolerate sustained hypoxic hypoxia, this study was performed to determine whether persons predisposed to hypertension have a normal tolerance of simulated high altitude. METHODS: Subjects were 18 young men with a family history of hypertension (sons of hypertensives, SOHT) whose BP values were in the upper normal or borderline hypertensive range. Controls were 15 young men without parental hypertension (sons of normotensives, SONT) who had normal BP values. Each subject underwent both a control and an altitude experiment. The latter consisted of an 8-h exposure to hypobaric hypoxia (equivalent to 4200 m) while resting supine in an altitude chamber. Fluids were administered by mouth and by intravenous line to produce sustained diuresis. Variables measured included heart rate, BP, respiratory rate, O2 saturation, urine flow rate, and sodium excretion. RESULTS: All subjects tolerated the control experiment and all SONT also completed altitude exposure. However, 8 of 18 SOHT developed antidiuresis and had to leave the chamber early due to symptoms of mild acute mountain sickness. Compared with SONT, SOHT exhibited more stable cardiorespiratory parameters at altitude. CONCLUSIONS: The data support the hypothesis that borderline hypertensives have stronger cardiorespiratory responses to altitude than controls, a response that is compatible with higher excitability of their arterial chemoreceptors. However, their altitude tolerance is reduced even at rest, probably because of the renal effects of an exaggerated response in the sympathetic nervous system.

Superiority of form% over Lambda for research on the Rorschach Comprehensive System.

Lambda is an important variable in the Rorschach Comprehensive System. However, because of the way it is calculated it has properties that can produce problems for parametric statistical analyses. We illustrate these difficulties and encourage the use of Form% (i.e., pure form responses/total responses) instead of Lambda in research. Form% is easy to calculate, and it is conceptually and mathematically comparable to Lambda. Because it is much more normally distributed, Form% is suitable to use in parametric analyses (e.g., t tests, analyses of variance, correlations, factor analyses, multiple regressions).

Clinical utility of the Rorschach with African Americans.

In this study we sought to identify Rorschach differences between African Americans and White Americans and to understand these differences within a social and cultural framework. Data from the Exner (1993) Comprehensive System normative sample (N = 700) was used to form a group of 44 African Americans and 44 White Americans matched for age, sex, education, and socioeconomic status. Twenty-three Rorschach variables were chosen a priori and group differences were analyzed. The only clinically significant difference found was that African Americans offered significantly less cooperative movement. This lower frequency of cooperative movement may suggest African Americans do not anticipate cooperative interactions with others as a routine event. This may reflect a shared feeling among African Americans that most members of our society are less likely to be sensitive to or responsive to their needs relative to others. However, the study demonstrates a striking similarity between the groups, supporting the clinical use of the Rorschach with African Americans.

Hyperbaric oxygen therapy does not affect recovery from delayed onset muscle soreness.

PURPOSE: This study investigated whether hyperbaric oxygen therapy (HBOT) improves recovery after exercise-induced muscle injury. METHODS: Healthy male subjects (N = 24) were randomly assigned to either a placebo group or a HBOT group. Subjects were tested for maximal isometric strength (preexercise) of their right elbow flexors. Each subject then completed a high-force eccentric workout of the elbow flexor muscle group to induce delayed onset muscle soreness (DOMS). On the seven successive days after this workout, the subjects were exposed to a hyperbaric environment of 2.5 ATA for 60 min, inspiring either a normoxic mixture (P(I)O2 = 0.2 ATA; placebo group) or a hyperoxic gas mixture (P(I)O2 = 2.5 ATA; HBOT group). Before the eccentric workout and daily for the next 10 d, measurements were obtained regarding: maximal isometric muscle strength of the elbow flexor muscles, right upper arm circumferences, and rating of the perceived muscle soreness. RESULTS: Isometric strength decreased significantly from preexercise levels of 25.1 +/- 3.8 kp to postexercise levels of 12.0 +/- 4.6 kp, for the HBOT group, and from 24.6 +/- 3.4 kp to 12.5 +/- 3.7 kp, respectively, for the placebo group. Over the 10-d recovery period, there was no difference in the rate of recovery of muscle strength between the two groups. Perceived soreness peaked at about 48 h after exercise with no difference between groups. Also, the exercise-induced increases in arm circumference were similar in the two groups. CONCLUSIONS: These results indicate that HBOT is not an effective therapy for the treatment of DOMS.

The future of Rorschach in personality assessment.

This article considers the Rorschach and its prospects for the next century in the context of two broad issues in psychology, as well as some test specific challenges confronting those interested in the Rorschach and its applications. The broad issues are the matters of personality as a topic of study in psychology, and the relation of findings about personality to treatment planning. The specific issues concern the definition of the Rorschach, research about the test stimuli, and the expansion of information concerning the interpretive usefulness of some structural variables that are poorly conceptualized or for which interpretation may be overly generalized. Some recommendations concerning collaborative research efforts are also offered.

Critical bits and the Rorschach response process.

This article reviews some of the basic elements of visual science, especially the concept of critical stimulus bits, as they apply to the Rorschach response process. Illustrations and data are presented to depict how stimulus features such as contour, position, color, and internal sets can be critical in encouraging or thwarting the selection of certain kinds of Rorschach answers. The findings are discussed in the context of detecting projected material in Rorschach answers.

Is the Rorschach welcome in the courtroom?

A survey of 7,934. recent federal and state court cases in which psychologists presented Rorschach testimony revealed only 6 in which the appropriateness of the Rorschach was challenged and just one in which the testimony was not admitted into evidence. There is accordingly good reason to believe that, despite occasionally voiced concerns to the contrary, the Rorschach is welcome in the courtroom.

Effects of acute hypoxia and hyperoxia on ventilation in spontaneously hypertensive and normotensive rat.

The aim of this study was to investigate whether there are differences between particular characteristics of the ventilatory responses to acute hypoxia and hyperoxia in primary hypertensive and normotensive states which might indicate significant differences in arterial chemoreceptor reflex function. Pneumotachographic monitoring of ventilation was carried out in anesthetized, spontaneously breathing, normotensive randomly bred Wistar rats (NWR), Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Under air breathing conditions, minute ventilation in SHR (50 +/- 2 ml/min per 100 g) was not significantly different from that of WKY (54 +/- 3 ml/min per 100 g) but NWR had a significantly lower minute ventilation (39 +/- 1 ml/min per 100 g) than both SHR and WKY. Our data indicate that there is no elevation of the ventilatory drive under air breathing conditions which can be unequivocally associated with primary hypertension in adult animals. During acute hypoxia, minute ventilation increased by a similar magnitude in SHR and NWR (by 97 and 77%, respectively, above baseline values), whereas in WKY the increase was only 58%. When exposed to acute hyperoxia, minute ventilation was inhibited by a similar degree in all animals investigated. We conclude that there is no characteristic pattern of peripheral chemoreceptor-mediated ventilatory responses in close association with primary hypertension.

Cardiorespiratory responses to acute hypoxia and hyperoxia in adult and neonatal spontaneously hypertensive and normotensive rats.

The aim of this study was to investigate whether there are differences between particular characteristics of breathing regulation in primary hypertensive and normotensive states which might indicate significant differences in arterial chemoreceptor reflex function. Under air-breathing conditions, minute ventilation was similar in adult spontaneously hypertensive rats (SHR) (50 +/- 2ml/min x 100 g) and in Wistar-Kyoto rats (WKY) (54 +/- 3 ml/min x 100 g) but significantly lower in randomly bred normotensive Wistar rats (NWR) (39 +/- 1 ml/min x 100 g). In seven-day-old rats minute ventilation was 10.5 +/- 1.2ml/min x 10 g in SHR and 10.2 +/- 1.4 ml/min x 10 g in WKY. Our data indicate that there is no elevation of the ventilatory drive under air-breathing conditions which can be unequivocally associated with primary hypertension in adult and neonatal animals. Acute inhibition of ventilation caused by hyperoxia indicated that oxygen dependent peripheral chemoreceptor activity during air-breathing was similar in SHR and normotensive controls both in the unanesthetized neonatal state and in anesthetized adult animals. No well defined association between the characteristics of the hypoxic ventilatory response and primary hypertension could be demonstrated although responses in adult anesthetized SHR tended to be faster and of higher amplitude than in normotensive controls.

Rorschach changes following brief and short-term therapy.

Two groups of 35 patients each, one treated with brief therapy, averaging 14.2 sessions on a once per week basis, and the other group, treated with a short-term type of therapy, averaging 47 sessions on a once per week basis were administered the Rorschach and the Katz Adjustment Scales-Form S three times. The first administration took place before entering therapy. The brief therapy group was tested a second time at termination of treatment and again 8 to 12 months following termination. The short-term therapy group was tested the second time at therapy termination and the third time 10 to 12 months after termination. Each group reported substantially fewer symptoms at termination and continued to report about the same level of symptom reduction at the second retest. The Rorschach data seem to provide an ample basis from which to argue that considerable improvement occurred in the psychological organization and/or operations of both groups, and this appears to have some confirmation in the self-report data.

R in Rorschach research: a ghost revisited.

As interest in Rorschach research has increased, an old issue-whether differences in R require that other scores be normalized in relation to R when Rorschach data are analyzed-has been resurrected. Most who advocate normalizing or partialing for R cite Cronbach (1949) or Fiske and Baughman (1953) as the basis for their argument. Although Cronbach offered several useful suggestions regarding this problem, the data base to which he referred and that used by Fiske and Baughman allowed for a much greater variation in R than occurs when Rorschach's standard instructions are applied. Intercorrelations between R and most parametric Rorschach variables are not significant among groups of nonpatients, schizophrenics, and depressives. Thus, although the issue of R can be critical when some variables are included in a data matrix, most analyses can proceed without partialing or normalization. When nonparametric variables are included in an analysis, partialing or normalizing is inappropriate because the resulting distributions will be distorted.

Radioimmunoassay of dibenzazepines and dibenzcycloheptanodienes in body fluids and tissues.

In an attempt to establish a radioimmunoassay (RIA), imipramine and amitriptyline immunogens were prepared; desmethyl derivatives were converted into hemisuccinates, conjugated with bovine serum albumin and used for rabbit immunization. [3H]Amitriptyline (4.3 TBq/mmol) and [3H]imipramine (2.9 TBq/mmol) were prepared by catalytic dehalogenation or reductive alkylation. Dibenzazepines and dibenzcycloheptanodienes were determined in biological fluids by a direct method without deproteinization (lower detection limit of 0.5 microgram.l-1); using high-yield methods they were extracted from cell membranes. Assay of tricyclic antidepressants in humans showed that these substances disappear from plasma much earlier than from cell membranes. Dissociation of the antidepressants bound to cell membranes is slow and their plasma concentrations are not influenced by standing for 2 h at 4 degrees C. During preparing the membranes for binding studies these substances are not removed, and they may affect the results of the binding studies.

Comments on "the Rorschach M response: a return to its roots".

These comments address three interrelated issues posed in Kramer's article concerning Rorschach's definition of the M response and the criteria for M that is applied in the Comprehensive System, the possibility that M may be overscored by the criteria for the Comprehensive System, and the issue of whether the Rorschach is amenable to quantification and empirical scrutiny. Kramer has oversimplified and misconstrued statements by Rorschach, Beck, and Bohm; in reality, the criterion for the scoring of M responses in the Comprehensive System differs very little, if at all, from that suggested by Rorschach. The accumulated history of the test seems to confirm that it is amenable to quantification and empirical scrutiny.

Rorschach changes in long-term and short-term psychotherapy.

Over a period of several years, repeat Rorschach testing was done with two groups of patients receiving outpatient psychotherapy, a long-term group (n = 88) engaged in intensive, dynamically oriented psychotherapy and a short-term group (n = 88) involved in behavioral or gestalt therapy. Rorschach protocols were obtained at the beginning of the treatment and on three subsequent occasions, 1 year, 2 1/2 years, and 4 years later, when most of the long-term and all of the short-term patients had completed their therapy. The findings demonstrate generally beneficial effects of psychotherapy, greater change in long-term than in short-term therapy, and the validity of the Rorschach for measuring these effects and changes.

Searching for projection in the Rorschach.

The issue of assumptions concerning projection and the Rorschach is discussed in relation to the Rorschach response process and the process of projection. Some data suggest that some minus answers may evolve because of projection, but the limited nature of the findings indicate that these types of projected answers will be difficult to identify in most cases. Findings concerning passive and aggressive movement responses, morbid content responses, and movement answers, coded using a new special score for positive cooperative interaction (COP) in human and animal movement responses, suggest that most projections will manifest in responses that depart from and/or embellish the stimulus field. Caution is recommended about attempting to interpret single answers tht appear to be projections, because most any might be the product of simple stimulus classification.

Bioremediation of chemical spills.

It is evident from the data collected to date that substantial progress was made in the remediation of the site prior to the shutdown of the bioreclamation system. Extrapolation of the data suggests that completion of the project was imminent. Further remediation at the site, including the possibility of expanding the original area treated with in situ bioreclamation, is pending further definition of the new sources of contamination. The success of the two projects described here demonstrates the efficacy and potential of enhanced bioreclamation in remediating contamination problems both in soils and in groundwater.

Some Rorschach data comparing schizophrenics with borderline and schizotypal personality disorders.

The Rorschach data from 84 borderline personality disorders and 76 schizotypal personality disorders, both groups diagnosed using DSM-III criteria, were compared with each other and with two sets of Rorschach protocols collected from 80 first admission schizophrenics, one being administered shortly after admission and the second taken shortly before discharge. The data indicate that the borderline group is markedly different in both organization and functioning from both other groups; however, there are many similarities between the records of the schizotypals and schizophrenics. It is suggested that nomenclatures such as borderline schizophrenia or latent schizophrenia might be more appropriate to designate the schizotypal group and that the once used, but now discarded, nomenclature of inadequate personality offers a more fitting description of the borderlines.

The reliability of Rorschach variables for inpatients presenting symptoms of depression and/or helplessness.

Fifty newly admitted patients presenting symptoms of depression and/or helplessness were recruited to participate in a study concerning depression and randomized into two groups. Rorschachs were administered shortly after admission and then three or four days later. The subjects in the experimental group were instructed to give responses different than they had in the first test. Approximately two-thirds of the responses given by the experimental group in test 2 were different from those in test 1, whereas the control subjects repeated 66% of their test 1 answers in test 2. Retest correlations for 28 variables critical to interpretation show that the two groups differed significantly for four. The retest correlations for four of five variables often used as indices of depressive features were significantly high for both groups. Unusual findings are noted in the retest correlations for FM and m for the Control group and questions are raised concerning the modest retest correlations for CF and C + Cn versus the more commonplace summation of CF + C.