ABSTRACT
[This corrects the article DOI: 10.1107/S1600536804004799.].
ABSTRACT
Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone glyoxime (L(1)H2) or 4-ethoxybenzaldehyde thiosemicarbazone glyoxime (L(2)H2)) thiosemicarbazone units were synthesized and characterized using (1)H NMR, (13)C NMR, HMQC, MS, infrared and, UV-VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L(1)H2 and L(2)H2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II) and Co(II) ions. The detection of H-bonding (O-Hâ¯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L(1)H2, L(2)H2, and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L(1)H2, [Ni(L1H)2], [Cu(L1H)2], L2H2, [Ni(L2H)2] and [Cu(L2H)2] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
Subject(s)
Coordination Complexes/chemistry , Coordination Complexes/pharmacology , Metals, Heavy/pharmacology , Oximes/chemistry , Oximes/pharmacology , Thiosemicarbazones/chemistry , Thiosemicarbazones/pharmacology , Absorption , Anti-Infective Agents/chemical synthesis , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Bacteria/drug effects , Cobalt/pharmacology , Coordination Complexes/chemical synthesis , Copper/pharmacology , Electrons , Fungi/drug effects , Hydrogen-Ion Concentration , Ligands , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Molecular Conformation , Nickel/pharmacology , Oximes/chemical synthesis , Solvents/chemistry , Spectrophotometry, Infrared , Spectrophotometry, Ultraviolet , Thiosemicarbazones/chemical synthesisABSTRACT
The title compound, 3-ethoxy-4-isopropylaminocyclobut-3-ene-1,2-dione (EIAC) has been synthesized and characterized by NMR, FT-IR, UV-vis spectroscopy and single-crystal X-ray diffraction. The (1)H NMR spectra were recorded at 300 K and 315 K in CDCl(3) to determine syn/anti conformers of the compound EIAC. Density functional theory (DFT) calculations, optimized geometrical parameters, vibrational frequencies and chemical shift values of syn/anti conformer in CDCl(3) have been performed at B3LYP/6-311G(d) level, and compared with the experimental data. The values provided with the calculations support the experimental data of the compound EIAC. The presence of NHâ¯O type intermolecular H bond can be perceived from the difference between experimental calculations and results of FT-IR and NMR calculations. In addition, B3LYP/6-311G(d) basis set has been used to calculate the molecular electrostatic potential, frontier molecular orbitals and electronic absorption spectra. HOMO-LUMO electronic transition of 5.12 eV is derived from the contribution of the bands nâσ(*) or πâπ(*). FT-IR, NMR and X-ray spectral results and additionally DFT calculations exhibit that the compound EIAC exists in keto-enamine tautomeric form. The experimental (1)H NMR spectra recorded at 300 K and 315 K and theoretical (1)H NMR data indicate that the compound EIAC is in syn conformer.
Subject(s)
Cyclobutanes/chemistry , Models, Molecular , Absorption , Crystallography, X-Ray , Electrons , Hydrogen Bonding , Magnetic Resonance Spectroscopy , Molecular Conformation , Spectroscopy, Fourier Transform Infrared , Static Electricity , Stereoisomerism , Thermodynamics , VibrationABSTRACT
In this work, 3,4-bis(isoproylamino)cyclobut-3-ene-1,2-dione C(10)H(16)N(2)O(2) (I), was synthesized and characterized by (13)C NMR, (1)H NMR, FT-IR, UV-vis spectroscopy and single-crystal X-ray diffraction. DFT method with 6-31G(d,p) basis set has been used to calculate the optimized geometrical parameters, atomic charges, vibrational frequencies and chemical shift values. The calculated vibrational frequencies and chemical shift values are compared with experimental FT-IR and NMR spectra. The results of the calculation shows good agreement between experimental and calculated values of the compound I. The existence of N-Hâ¯O type intermolecular ve C-Hâ¯O type intramolecular hydrogen bonds can be deduced from differences between experimental and calculated results of FT-IR and NMR. In addition, the molecular electrostatic potential map and frontier molecular orbitals and electronic absorption spectra were performed at B3LYP/6-31G(d,p) level of theory. HOMO-LUMO electronic transition of 4.90 eV are derived from the contribution of the bands πâπ* and nâπ* The spectral results obtained from FT-IR, NMR and X-ray of I revealed that the compound I is in predominantly enamine tautomeric form, which was supported by DFT calculations.
Subject(s)
Cyclobutanes/chemistry , Propylamines/chemistry , Crystallography, X-Ray , Hydrogen-Ion Concentration , Magnetic Resonance Spectroscopy , Models, Molecular , Molecular Conformation , Quantum Theory , Spectroscopy, Fourier Transform Infrared , Static ElectricityABSTRACT
Addition of LDA to a mixture of trimethylborate and dibromomethane in THF at a temperature of -78°C leads to the formation of dibromomethyllithium and its capture by borate ester. ClB(OMe)(2) converts the resulting borate salt to dimethoxy(dibromomethyl)borane 2. N,N-Dimethylamino(methoxy)(dibromomethyl)borane 3 and N,N-bis(dimethylamino)(dibromomethyl)borane 4 were prepared by an amination reaction between N,N-dimethylaminotrimethylsilane and dimethoxy(dibromomethyl)borane 2. To obtain dichlorotrimethylsilylmethylborane 7 not containing the α-halomethyl group, N,N-bis(dimethylamino)(trimethylsilylmethyl)borane 5 was first obtained from the reaction of ClB(NMe(2))(2) with an organolithium reagent. Dimethoxy(trimethylsilylmethyl)borane 6 was then prepared by methoxylation of compound 5. Finally, compound 7 was prepared by chlorination of 6 using BCl(3). The chemical structures of these compounds were determined using (13)C, (1)H, (11)B NMR and GC/MS/MS techniques.