Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Acta Derm Venereol ; 103: adv3713, 2023 Mar 28.
Article in English | MEDLINE | ID: mdl-36987539

ABSTRACT

Folliculitis decalvans is a chronic inflammatory skin disease leading to scarring alopecia. Management of this disabling disease is difficult and no treatment is currently approved. Current knowledge regarding the pathogenesis of folliculitis decalvans suggests the benefit of using anti-tumour necrosis factor-α. This pilot study aimed to evaluate the clinical efficacy of anti-tumour necrosis factor-α for management of folliculitis decalvans. A single-centre retrospective pilot study included patients with refractory folliculitis decalvans treated by tumour necrosis factor-α inhibitors. An Investigator's Global Assessment (IGA) score was designed and validated to assess the efficacy of the therapy. Response to treatment was considered good to excellent when an IGA ≤ 2 was obtained at month 12. Eleven patients were included, with a mean time from diagnosis of folliculitis decalvans to the introduction of infliximab (n = 9) or adalimumab (n = 2) of 8.55 ± 1.26 years. Nine patients had failed on at least 2 lines of systemic therapies before starting anti-tumour necrosis factor-α. The median IGA score at baseline was 3. At the end of follow-up, 5 patients were considered responders. Overall, the safety profile of anti-tumour necrosis factor-α was good. The results suggest that the clinical benefit of anti-tumour necrosis factor-α is obtained after at least 6 months of treatment. However, further prospective studies are needed to confirm these results.


Subject(s)
Folliculitis , Tumor Necrosis Factor Inhibitors , Humans , Tumor Necrosis Factor Inhibitors/therapeutic use , Pilot Projects , Retrospective Studies , Alopecia/etiology , Folliculitis/diagnosis , Folliculitis/drug therapy , Folliculitis/pathology , Necrosis/complications , Immunoglobulin A
2.
Pediatr Dermatol ; 36(2): 260-261, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30791146

ABSTRACT

We report a 6-month-old girl born with a fronto-parietal patch of hair straighter than the remainder of the scalp hairs. We took a biopsy to rule out a congenital melanocytic nevus. We concluded after additional scanning electron microscopy study of the hair shafts that the lesion corresponds to a possible local mosaicism causing an isolated straight hair nevus phenotype.


Subject(s)
Hair Diseases/diagnosis , Hair/pathology , Nevus, Pigmented/diagnosis , Female , Hair Diseases/pathology , Humans , Infant , Microscopy, Electron, Scanning , Mosaicism
3.
Acta Derm Venereol ; 98(6): 570-575, 2018 Jun 08.
Article in English | MEDLINE | ID: mdl-29542810

ABSTRACT

Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1ß and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1ß, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1ß expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1ß blockade in FD.


Subject(s)
Adaptor Proteins, Signal Transducing/analysis , Apoptosis Regulatory Proteins/analysis , Folliculitis/metabolism , Hair Follicle/chemistry , Inflammasomes/chemistry , Interleukin-1beta/analysis , NLR Family, Pyrin Domain-Containing 3 Protein/analysis , Scalp Dermatoses/metabolism , Scalp/chemistry , Adult , Aged , Biomarkers/analysis , Biopsy , Female , Folliculitis/immunology , Folliculitis/pathology , Hair Follicle/immunology , Hair Follicle/pathology , Humans , Immunohistochemistry , Inflammasomes/immunology , Interleukin-8/analysis , Male , Middle Aged , Myxovirus Resistance Proteins/analysis , NLR Proteins , Retrospective Studies , Scalp/immunology , Scalp/pathology , Scalp Dermatoses/immunology , Scalp Dermatoses/pathology , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...