Development and formulation of antidiabetic property of Anarcadium occidantale-based solid lipid microparticles.

Anacardium occidentale (AO) possesses potent anti-diabetic properties, owing to its high phytochemicals content. This study attempted to maximise the efficacy of AO by encapsulating it in a solid lipid microparticle (SLMs) formulation. Leaves of AO were extracted with water and formulated into SLMs using a lipid matrix composed of P90H and Dika fat. Characterisation of the SLMs include morphology, particle size, pH, encapsulation efficiency percentage, in vitro release and anti-diabetic properties. SLMs were spherical with sizes ranging from 16.7 ± 0.8 µm to 40.12 ± 2.34 µm and had a fairly stable pH over time. Highest drug entrapment was 87%. Batch A2 exhibited an even release of 89%, sustained over time, and a mean percentage reduction in glucose of 25.9% at 12 h after oral administration to study animals. Anacardium occidentale-loaded SLMs exhibited a good hypoglycaemic effect and can be used in the management of diabetes.

PEGylated aceclofenac solid lipid microparticles homolipid-based solidified reverse micellar solutions for drug delivery.

Aceclofenac is a non-steroidal anti-inflammatory drug with poor aqueous solubility and a short half-life resulting in low bioavailability. Aceclofenac-loaded solid lipid microparticles based solidified reverse micellar solution (SLMs-SRMS) for oral drug delivery was investigated to improve the bioavailability and control drug release. Hot homogenization method was adopted to prepare the SLMs using a homolipid irvingia fat and Phospholipon® 90H with or without propylene glycol 6000 (PEGylation) in different ratios and characterized in vitro. The in vivo anti-inflammatory activity of the drug was determined on mice inflamed with carrageenan as phlogistic agent. Results showed that the morphology and particle sizes of the SLMs were spherical and smooth and ranged between 5.24 ± 0.01-97.44 ± 0.18 µm. EE % ranged between 67 - 81 %. A significant (p < 0.05) viscosity of 490 mPasec-1 was obtained. FTIR spectra indicated compatibility amongst the constituents. DSC showed a broad peak which depicted an imperfect matrix resulting in a deformation of crystal arrangement creating many spaces for drug entrapment. Delayed drug release was observed in almost all the formulations in SIF (pH, 6.8). Anti-inflammatory activity showed a significant inhibitory effect (p < 0.05, up to 90 %). Hence, the aceclofenac-loaded SLMs-SRMS showed desirable characteristics and could be used for controlled delivery of aceclofenac and thus alternative to conventional aceclofenac oral formulation.