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Bioorg Med Chem Lett ; 21(10): 3117-21, 2011 May 15.
Article in English | MEDLINE | ID: mdl-21458262

ABSTRACT

A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.


Subject(s)
Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/pharmacology , Pyrroles/chemical synthesis , Pyrroles/pharmacology , Antineoplastic Agents/chemistry , Cell Line, Tumor , Cell Proliferation/drug effects , Drug Screening Assays, Antitumor , Humans , Molecular Structure , Naphthoquinones/chemistry , Pyrroles/chemistry , Structure-Activity Relationship
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