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1.
NO-independent stimulators of soluble guanylate cyclase.
Straub, A; Stasch, J P; Alonso-Alija, C; Benet-Buchholz, J; Ducke, B; Feurer, A; Fürstner, C.
Bioorg Med Chem Lett ; 11(6): 781-4, 2001 Mar 26.
Article in English | MEDLINE | ID: mdl-11277519

ABSTRACT

SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.


Subject(s)
Enzyme Activators/pharmacology , Guanylate Cyclase/metabolism , Indazoles/pharmacology , Animals , Aorta/drug effects , Aorta/physiology , Enzyme Activators/chemical synthesis , Enzyme Activators/chemistry , Indazoles/chemical synthesis , Indazoles/chemistry , Pyrazoles/chemistry , Pyrazoles/pharmacology , Pyridines/chemistry , Pyridines/pharmacology , Rabbits , Structure-Activity Relationship , Vasodilation/drug effects
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