The use of serosurveys following emergency vaccination, to recover the status of "foot-and-mouth disease free where vaccination is not practised".

To eliminate incursions of foot-and-mouth disease (FMD) quickly, a combination of measures, including emergency vaccination, can help block the spread of infection. For the earliest recovery of the FMD-free status for trade, without the slaughter of uninfected vaccinated animals, a serosurvey for antibodies to FMD virus non-structural proteins (NSP) must be used to substantiate absence of occult virus infections. Areas of doubt over requirements for post-vaccination serosurveillance and its feasibility include the required and achievable confidence, the amount of sampling necessary, and the appropriate responses to and consequences of different seropositive findings. This derives largely from uncertainty over the extent of localised pockets of virus infection that may remain within vaccinated populations and the circumstances that permit this. The question therefore remains whether tests are sufficiently sensitive and specific to detect and eliminate infected animals, without excessive culling of uninfected animals, before vaccinated animals mix with non-vaccinated livestock when movement restrictions are lifted. It is recommended to change the rationale for serosurveillance after emergency vaccination. Only when emergency vaccination is used in limited outbreaks is it possible to test and cull comprehensively, an approach compatible with a three-month minimum period to recover the FMD-free status. In other situations, where emergency vaccination is used, such as dealing with large outbreaks in animal-dense regions and where the onset of vaccination has been delayed, post-vaccination serosurveys should be targeted and focus on providing an assurance to detect higher levels of infection, in case of inadequate control measures. As this provides less assurance of absence of infection, the approach would be compatible with a six-month waiting period for free-status recovery and should be complemented by other methods to provide evidence that vaccination and control measures have been effectively implemented, as these are the best guarantee against continuing virus transmission.

Equine travellers to the Olympic Games in Hong Kong 2008: a review of worldwide challenges to equine health, with particular reference to vector-borne diseases.

The past 10-20 years have seen exponential growth in the volume of trade in horses and equine germplasm; and the extent of global horse movements has increased significantly in the last 4 years. In preparing for the transport of elite Olympic horses to Hong Kong in 2008, it will be very important to be as fully informed as possible of the disease situation in both the exporting and importing country, import and re-entry requirements, as well as having a vaccination strategy to protect against particular diseases. In this context the review describes the equine vector-borne disease situation in Europe, Asia, Africa and South America and provides estimates of the number of horse movements between these countries, as well as information on import requirements and vaccination strategies.

Antigen and vaccine banks: technical requirements and the role of the european antigen bank in emergency foot and mouth disease vaccination.

Antigen and vaccine banks are stocks of immunogenic materials ready to be formulated into vaccines (bulk antigens) or ready to use (vaccines) in case of need by one or more of the parties of the bank. These stocks were primarily developed by foot and mouth disease [FMD] free European countries to control unexpected severe FMD episodes after the cessation of routine vaccination in the 1990s. For various reasons, including the lack of suitable antigens or of discriminatory tests to be used following emergency vaccination, such banks have so far not been developed to control other transboundary diseases, although over the last few years stocks of vaccines have been collected by the European Community to support control measures for bluetongue or classical swine fever. The FMD virus antigens in the banks are stored at ultra-low temperatures (usually -130 degrees C) to guarantee a shelf life of at least five years compared to a shelf-life of one to two years for vaccines stored at +4 degrees C. When concentrated, a 50 I volume of antigens can contain up to 15 million cattle doses as per the standard potency specifications in the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. Selecting antigen/vaccine strains for storage in a bank and selecting the appropriate strain(s) to be used in the case of emergency vaccination is the responsibility of FMD disease experts. The paper discusses the role of serological testing for the detection of infected animals in a vaccinated population, which is necessary for the recognition of FMD status. Technical advantages and disadvantages of antigen and vaccine banks in general are also outlined in this article. Finally, the experience of the European Community in organising, renewing, and controlling a sizeable FMD antigen bank since 1993 is discussed, and the use of the European Union (EU) antigen bank for international actions outside the EU is presented.

The use of antigen and vaccine banks in case of emergency vaccination in the European community.

The Community control measures for foot-and-mouth disease (FMD) have been reviewed and are currently laid down in Directive 2003/85/EC of 29 September 2003. The Community is free of FMD and infection without practising vaccination. Legal provisions are in place to resort to emergency vaccination where required by the epidemiological situation and reserves of suitable antigens of the FMD virus for express formulation into vaccines have been established.

Legislative requirements for the identification and traceability of farm animals within the European Union.

European Community (EC) legislation requires identification and registration of bovine, ovine, caprine and porcine animals. For intra-Community trade, bovine animals must be accompanied by a passport and the required health certificate, and identified by a tag on each ear. The principles of active identification of bovine animals (by ear tags) and of ovine, caprine and porcine animals (by ear tags or tattoos) are harmonised within the EC. International passports are issued and recognised only for registered Equidae. The life-number was introduced as an instrument to allow uninterrupted identification of Equidae using passports. The principles of issuing and recording such numbers have been outlined by the affected industries, but require official approval. Active identification of Equidae using electronic devices is not regulated by EC legislation, but research in livestock is underway.