Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2.

Correction to: The Journal of Antibiotics (2015) 68, 165­177; doi:10.1038/ja.2014.118, published online 3 September 2014. The authors noted errors upon publication of this article in the 'Results and Discussion' section. The molecular formulas presented for compounds 1­5 in the "Isolation procedure and structure elucidation" section are incorrect. These formulas should read as follows: 1. C37H57NO7 2. C37H56ClNO7 3. C38H56Cl2N2O8 4. C37H55Cl2NO7 5. C37H54Cl3NO7

Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2.

The methanol extract of the Vietnamese freshwater cyanobacterium Nostoc sp. CAVN2 exhibited cytotoxic effects against MCF-7 and 5637 cancer cell lines as well as against nontumorigenic FL and HaCaT cells and was active against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. High-resolution mass spectrometric analysis indicated the presence of over 60 putative cyclophane-like compounds in an antimicrobially active methanol extract fraction. A paracyclophanes-focusing extraction and separation methodology led to the isolation of 5 new carbamidocyclophanes (1-5) and 11 known paracyclophanes (6-16). The structures and their stereochemical configurations were elucidated by a combination of spectrometric and spectroscopic methods including HRMS, 1D and 2D NMR analyses and detailed comparative CD analysis. The newly described monocarbamoylated [7.7]paracyclophanes (1, 2, 4 and 5) differ by a varying degree of chlorination in the side chains. Carbamidocyclophane J (3) is the very first reported carbamidocyclophane bearing a single halogenation in both butyl residues. Based on previous studies a detailed phylogenetic examination of cyclophane-producing cyanobacteria was carried out. The biological evaluation of 1-16 against various clinical pathogens highlighted a remarkable antimicrobial activity against MRSA with MICs of 0.1-1.0 µM, and indicated that the level of antibacterial activity is related to the presence of carbamoyl moieties.

[Higher fungi in traditional and modern medicine]. / Höhere Pilze in der traditionellen Heilkunde und Medizin.

The medicinal use of mushrooms, so-called higher fungi, has a very long tradition in the Asian countries, whereas their use in the Western hemisphere has been slightly increasing only since the last decades. The paper gives an overview about the most important medicinal mushrooms and summarizes the actual knowledge about chemistry and pharmacology of Lentinula edo-des (Shiitake, Golden Oak Mushroom), Ganoderma lucidum (Reishi, Ling Zhi), Agaricus brasiliensis (Royal sun agaricus), Grifola frondosa (Maitake, Hen-of-the-Woods) and Hericium erinaceus (Yamabushitake, Lion's Man, Monkey's Head).