Investigation of retrospective respiratory gating techniques for acquisition of thin-slice 4D-Multidetector-computed Tomorgraphy (MDCT) of the lung: Feasibility study in a large animal model.

Respiratory gated 3D-MDCT acquisition of the whole chest over time (4D-MDCT) allow retrospective reconstruction of raw data at any point of the respiratory cycle might be beneficial in severely ill or sedated patients. Aim of this feasibility study was to investigate 2 prototype devices as input for retrospective respiratory gating in order to calculate lung volumes (LVs) and mean lung densities (MLDs) over time. Sixteen-row MDCT data were acquired in 5 ventilated pigs using a laser sensor and charge-coupled devine (CCD) camera and retrospectively reconstructed at every 10% of the respiratory cycle. Semiautomatic segmentation of the 3D data sets was performed, and LV and MLD were calculated. Data acquisition was successful in all cases. The mean difference of LV between maximum inspiration and expiration was 246 and 240 mL (laser and CCD, respectively). The mean difference of MLD between inspiration and expiration was 70 (laser) and 67 (CCD) HU. The lowest MLD was found at the beginning of the respiratory cycle (0%) for laser, and at 90% for CCD. Both gating devices allowed for reliable 4D-MDCT image acquisition. No differences were found for calculated LV and MLD, whereas the respiratory cycle was more precisely detected using the laser based gating device.

Free-breathing three-dimensional computed tomography of the lung using prospective respiratory gating: charge-coupled device camera and laser sensor device in an animal experiment.

PURPOSE: The aim was to investigate the feasibility and image quality of prospective respiratory gating for 3-D computed tomography (CT) of the lung. MATERIAL AND METHODS: Eight anesthetized pigs underwent prospectively gated multidetector computed tomography using 2 devices: a charge-coupled device (CCD) camera and a laser sensor. The output signal of both gating devices was connected to the scanner instead of ECG unit. Inspiratory and expiratory images were obtained during "free-breathing" and analyzed in MPR mode for sharpness of bronchi, diaphragm and lung using a 4-point-score (1, excellent to 4, severe artifacts). RESULTS: The CCD camera worked in all animals. Using the laser sensor, only 50% of expiratory scans could be acquired. All acquired images showed excellent sharpness (CCD camera vs. laser sensor) for trachea (1.1 +/- 0.3 vs. 1.3 +/- 0.5), bronchi (1.4 +/- 0.7 vs. 1.8 +/- 0.6), lung fissures (1.0 vs. 1.1 +/- 0.3), and lung parenchyma (1.0 +/- 0.2 vs. 1.4 +/- 0.6), and minor to major artifacts for diaphragm (1.5 +/- 0.8 vs. 2.0 +/- 1.0, P < 0.05) and pericardial lung structures (1.9 +/- 0.7 vs. 2.3 +/- 0.5). CONCLUSION: High image quality for inspiratory and expiratory scans was achieved by free-breathing 3-D CT of the lung using noncontact prospective respiratory gating.