[The functional status of the endocrine pancreas in patients with acute intestinal infections]. / Funktsional'noe sostoianie éndokrinnoi chasti podzheludochnoi zhelezy u bol'nykh s ostrymi kishechnymi infektsiiami.

RIA was used to measure the content of insulin, C-peptide and glucagon in blood plasma of 84 patients with acute dysentery and food toxicoinfections. The studies were carried out in the acute disease period and before the discharge from hospital. The data obtained indicate that despite the appreciable differences in the disease pathogenesis, the pathophysiological mechanisms influencing pancreatic function are similar in many respects. The changes are characterized by an increase in plasma insulin and a reduction in C-peptide and glucagon. The content of hormones in the peripheral blood is dependent on the disease period. In the authors' opinion, despite the high insulin content, the reduced level of C-peptide attests to hypofunction of beta-cells in acute intestinal infection, since it reflects their function more precisely. The reduced content of plasma glucagon points to hypofunction of alpha-cells.

[Pancreatic hormones and gastrin in patients with acute dysentery]. / Pankreaticheskie gormony i gastrin u bol'nykh ostroi dizenteriei.

The incretory pancreatic function has been studied in 35 patients with a moderately severe course of acute dysentery. The blood plasma content of insulin, glucagon and gastrin was determined by means of radioimmunoassay with standard kits during the acute course of the disease and prior to discharge of patients. The endocrine pancreatic function was found to be deranged with an increased insulin content during convalescence; the glucagon content was decreased during the period of the disease and the gastrin content was decreased in the acute period.

[Indices of endocrine activities of the digestive organs in patients with dysentery]. / Nekotorye pokazateli éndokrinnoi deiatel'nosti organov pishchevareniia u bol'nykh dizenteriei.

Some indices of pancreatic endocrine function were studied over time in patients with acute dysentery. The plasma levels of insulin, C-peptide, glucagon, and gastrin were determined by a radioimmunoassay. 35 patients and 30 healthy controls were examined. Clinical signs of the affection of the pancreas in the patients were undetectable. However, significant reduction of the level of C-peptide in the acute period of disease as compared to the normal level, an increase in the level of insulin during early convalescence, and the reduction of gastrin concentration during the entire period of disease were noted. These indices are indicative of disorder of pancreatic endocrine function in patients with acute dysentery.