ABSTRACT
Recurrent gallstones are the limiting factor for every non surgical treatment. In order to determine the optimal prevention therapy, 30 patients after successful dissolution therapy of microcholelithiasis (MCL) with ursodeoxycholic acid (UDCA), were randomized by the double blind method to receive UDCA therapy. This was administered either as 150 mg (N = 15, group I) or 300 mg per day (N = 15, group II). There was a follow-up period of 12 months with clinical examination every month and upper abdominal sonography on days 180 and 360. Recurrent gallstones, after a 12-month period, was 6.7% (1/15) in group II versus 66% (10/15) in group I (P < 0.005). When recurrence was examined according to the number of gallstones, it reached 8% (1/12) in the solitary MCL vs 55.5% (10/18) in multiple MCL (P < 0.005). The recurrence was always symptomatic (biliary pain) and developed in 11 out of 30 pts, as MCL in 7 and as biliary sludge in the remainder 4. We conclude that a daily dose of 300 mg of UDCA was effective in reducing the recurrent gallstones in more than 90% of cases treated for 12 months. The significant risk factors associated with recurrence were the UDCA low dose and multiple stones. Biliary sludge represented 36% of the recurrence.
Subject(s)
Cholelithiasis/drug therapy , Gastrointestinal Agents/administration & dosage , Ursodeoxycholic Acid/administration & dosage , Double-Blind Method , Female , Humans , Male , Middle Aged , Prospective Studies , RecurrenceABSTRACT
The intraabdominal punction tecnique is harmless and causes very little disturvance to the patient. It gives the pathologist enough adequate material for his diagnosis. The abdominal punction using a chiba needle also permits one to evaluate the extension of the illness. Medical literature only states a few complications such as peritonitis in pancreatic punctions. The diagnosis of no-Hodking Lymphoma based on the monomorphism and the sizes and the nuclear clefts, does no ofter many difficulties, nervertheless, the obtained material does not allow one to differenciate between nodular and diffuse lymphoma and therapeutic datum. It this sense, Histology surpasses Cytology (AU)
Subject(s)
Middle Aged , Humans , Male , Lymphoma, Non-Hodgkin/diagnosis , Abdominal Neoplasms/diagnosis , Punctures/methods , UltrasonographyABSTRACT
The intraabdominal punction tecnique is harmless and causes very little disturvance to the patient. It gives the pathologist enough adequate material for his diagnosis. The abdominal punction using a chiba needle also permits one to evaluate the extension of the illness. Medical literature only states a few complications such as peritonitis in pancreatic punctions. The diagnosis of no-Hodking Lymphoma based on the monomorphism and the sizes and the nuclear clefts, does no ofter many difficulties, nervertheless, the obtained material does not allow one to differenciate between nodular and diffuse lymphoma and therapeutic datum. It this sense, Histology surpasses Cytology
Subject(s)
Middle Aged , Humans , Male , Abdominal Neoplasms/diagnosis , Lymphoma, Non-Hodgkin/diagnosis , Punctures , UltrasonographyABSTRACT
The intraabdominal punction technique is harmless and causes very little disturbance to the patient. It gives the pathologist enough adequate material for his diagnosis. The abdominal punction using a Chiba needle also permits one to evaluate the extension of the illness. Medical literature only states a few complications such as peritonitis in pancreatic functions. The diagnosis of non-Hodgkin's Lymphoma based on the monomorphism and the sizes and the nuclear clefts, does not offer many difficulties, nevertheless, the obtained material does not allow one to differentiate between nodular and diffuse lymphoma, this being a very important prognostic and therapeutic datum. In this sense, Histology surpasses Cytology.
Subject(s)
Abdominal Neoplasms/diagnosis , Lymphoma, Non-Hodgkin/diagnosis , Punctures/methods , Humans , Male , Middle Aged , UltrasonographyABSTRACT
The intraabdominal punction technique is harmless and causes very little disturbance to the patient. It gives the pathologist enough adequate material for his diagnosis. The abdominal punction using a Chiba needle also permits one to evaluate the extension of the illness. Medical literature only states a few complications such as peritonitis in pancreatic functions. The diagnosis of non-Hodgkins Lymphoma based on the monomorphism and the sizes and the nuclear clefts, does not offer many difficulties, nevertheless, the obtained material does not allow one to differentiate between nodular and diffuse lymphoma, this being a very important prognostic and therapeutic datum. In this sense, Histology surpasses Cytology.
