1.
Antimicrob Agents Chemother
; 54(12): 5369-71, 2010 Dec.
Article
in English
| MEDLINE
| ID: mdl-20876372
ABSTRACT
Oritavancin is an investigational lipoglycopeptide in clinical development for the treatment of acute bacterial skin and skin structure infections. In this study, we demonstrate that oritavancin causes bacterial membrane depolarization and permeabilization leading to cell death of Gram-positive pathogens and that these effects are attributable to the 4'-chlorobiphenylmethyl group of the molecule.