Siamese twins thoraco-omphalipagous

No disponible

Insulin sensitivity and insulin secretion in lean and obese normal pregnant women.

An insulin-modified frequently sampled intravenous glucose tolerance test with minimal model analysis was performed in normal pregnant women between 28-32 weeks of gestation, to assess insulin sensitivity and insulin secretion. Insulin sensitivity in the pregnant group (no. 26) was reduced to approximately 50% that of nonpregnant group (no. 27) (p < 0.05). This increased insulin resistance was compensated by an enhancement of the first phase of insulin secretion, which was increased more than twofold in the pregnant women when compared with the nonpregnant women (p < 0.05). There was a trend toward greater insulin resistance and insulin secretion in the obese pregnant women (no. 7) as compared with the lean pregnant women (no. 19) although this difference was not statistically significant. Our findings confirm that late pregnancy is a state of physiologic insulin resistance compensated by an increase of insulin secretion.

Delivery in diabetic pregnancy.

Two hundred and twenty deliveries of diabetic pregnant women, occurring from 1990-1994 were studied: 186 gestational (GDM) and 34 pregestational diabetes (PGDM). Women who delivered during the year of 1994 were considered as control population (3615 births). Mode of delivery, planned delivery, delivery's gestational age, shoulder dystocia, macrosomia and large for gestational age (LGA) were investigated. Cesarean section and planned delivery were respectively 39% vs 20.5% and 51.6% vs 16% respectively in diabetic vs control women. Deliveries after 40 weeks were 29% in GDM, 3% in PGDM and 50% in control women. Macrosomia occurred in 17.7% of diabetic against the 8% of controls. Finally shoulder dystocia occurred in the 3.6% of diabetic women against the 0.3% of the control group. These data indicate that in our diabetic population there is a high rate of cesarean sections and planned deliveries, as well as macrosomia, LGA and shoulder dystocia. Obstetric decision to allow the delivery to term or near term was not enough to bring the rate of macrosomia and LGA close to the normal, which can be consequence of the diabetic control in pregnancy, in spite of intensive care intervention.

[Pregnancy and endocrinopathy. Activity, pathology and results at the outpatient obstetrics-endocrinology clinics of the University of Coimbra Hospitals--January 1980 through December 1988]. / Gravidez e endocrinopatias. Movimento, patologias e resultados da consulta externa de obstetrícia-endocrinologia dos Hospitais da Universidade de Coimbra--Janeiro de 1980 a Dezembro de 1988.

The authors have elaborated a statistic survey about the pregnant women with endocrinopathies, that they have examined in the outpatient clinic from January of 1980 to December of 1988. Three hundred and twenty four women were examined in an amount of 2152 (two thousand one hundred and fifty two) observations. The incidence for 100 births was 0.54%. Maternal and fetal mobility and mortality were analysed in correlation with the maternal area of endocrinopathy (Diabetes Mellitus, Thyroid, Hypophysis and Adrenal Glands) and with the necessary therapeutic regimens. At last the A.A. made some considerations about the importance of a team approach in this area of medical care, and applied to the clinicians who work in primary care, to a better collaboration.