ABSTRACT
The antioxidative activity of ionol, 2,2'methylene-bis(6-tert-butyl-4-methylphenol), 2,2-ethylenebis (6-tert-butyl-4-methylphenol), 2,2-propylenebis (6-tert-butyl-4-methylphenol, 2,2-butylenebis (6-tert-butyl-4-methylphenol) was studied in models and in albino rats with experimental hyperthyroidism. The most intensive extinguishing of induced chemiluminescence was found to be produced by 2,2-methylenebis (6-tert-butyl-4-methylphenol) and 2,2-ethylenebis (6-tert-butyl-4-methylphenol). These substances produced the most inhibitory effects on lipid peroxidation in the heart of hyperthyroidism animals.
Subject(s)
Antioxidants/pharmacology , Phenols/pharmacology , Animals , Antioxidants/therapeutic use , Drug Evaluation, Preclinical , Heart/drug effects , Hyperthyroidism/drug therapy , Hyperthyroidism/metabolism , Lipid Peroxidation/drug effects , Luminescent Measurements , Male , Myocardium/metabolism , Phenols/therapeutic use , RatsABSTRACT
Experiments on white rats show that reserpine creates conditions for acetylcholine accumulation in the heart. In early periods after reserpine administration (within 8 hours) this process depends on restriction of mediator hydrolysis. In more distant periods (within 24 hours) synthesis activation adds to the mentioned mechanism.
Subject(s)
Heart/drug effects , Receptors, Cholinergic/drug effects , Reserpine/pharmacology , Acetylcholine/metabolism , Animals , Choline O-Acetyltransferase/metabolism , Myocardium/metabolism , Rats , Receptors, Cholinergic/metabolism , Time FactorsSubject(s)
Acetylcholine/biosynthesis , Myocardium/metabolism , Thyrotoxicosis/metabolism , Animals , Choline/metabolism , Male , Pyruvates/metabolism , RatsSubject(s)
Heart Rate , Hyperthyroidism/physiopathology , Vagus Nerve/physiopathology , Animals , Electrocardiography , Male , RatsSubject(s)
Acetylcholine/metabolism , Movement , Myocardium/metabolism , Animals , Female , Male , Rats , Time FactorsABSTRACT
Changes in the sum total activity of cholinesterase of the plasma and erythrocytes (AC substrate) and also separately of acetyl- and pseudocholinesterase (MeC and ByC substrates) were studied in experiments on rats with thyrotoxin toxicosis and 6-methylthiouracil hypothyroidism. The sum total activity of cholinesterase proved to increase in the erythrocytes of rats with thyrotoxicosis and fell in the erythrocytes and plasma of animals with hypothyroidism. The activity of acetylcholinesterase of erythrocytes and plasma increased in thyrotoxicosis and decreased in hypothyroidism. The activity of pseudocholinesterase of erythrocytes and plasma decreased in thyrotoxicosis and showed no significant difference in hypothyroidism.
