ABSTRACT
The osteoprotective effect of resveratrol and a combination of resveratrol with enalapril has been investigated in white Wistar female rats with experimental osteoporosis. It is established that, in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of the osteal tissue is developed, resulting in the occurrence of osteoporosis. Resveratrol and the combination of resveratrol with enalapril prevented depression of the microcirculation level in the osteal tissue, thus preventing the thinning of osteal trabecules and preventing their microfractures.
Subject(s)
Enalapril/therapeutic use , Endothelium/physiopathology , Microcirculation/drug effects , Osteoporosis/drug therapy , Stilbenes/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Animals , Bone and Bones/blood supply , Bone and Bones/physiopathology , Drug Therapy, Combination , Endothelium/blood supply , Female , Ovariectomy , Rats , Rats, Wistar , Resveratrol , Vasodilator Agents/therapeutic useABSTRACT
In tests on a group of 250 rats, we studied (i) the level of microcirculation in the muscles of a healthy limb in the norm and (ii) the dynamics of microcirculation for 6 h after treatment with pentoxifylline in a dose of 60 mg/kg dose and L-arginine in a dose of 30 and 200 mg/kg. The chronic ischemia was modeled by excision of basic femoral artery. There was no significant difference in pentoxyfilline-treated animals in comparison to the control. In the group treated with L-arginine in a dose of 30 mg/kg, a significant increase in microcirculation was observed on the 28-th day of experiment. In the group treated with L-arginine in a dose of 200 mg/kg, there was an increase of microcirculation in all terms of the experiment in comparison to the control. The results of laser doppler flow measurements are correlated with the results of morphological investigation.
