ABSTRACT
Methanolic extract of Opuntia dillenii cladodes and its pure compound alpha-pyrone glycoside, opuntioside-I showed potent hypotensive activity in normotensive rats. Both the extract and opuntioside-I showed comparable effect of 44-54% fall in Mean Arterial Blood Pressure (MABP) at the dose of 10 mg/kg. No mortality was observed in rats even at the doses of 1000 mg/kg/d and 900 mg/kg/d per oral of extract and opuntioside-I respectively. However, histopathology revealed adverse effects of high doses on liver and spleen of the experimental animals.
Subject(s)
Antihypertensive Agents/pharmacology , Monosaccharides/pharmacology , Opuntia/chemistry , Plant Extracts/pharmacology , Animals , Antihypertensive Agents/toxicity , Bilirubin/blood , Blood Glucose/analysis , Blood Proteins/analysis , Cholesterol/blood , Monosaccharides/toxicity , Plant Extracts/toxicity , Rats , Spleen/drug effects , Spleen/pathologyABSTRACT
A novel constituent, shamimicin, 1"', 1"""'-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran along with lupeol, which possesses potent hypotensive activity, has been isolated from Bombax ceiba stem bark. BCBMM--one of the most active hypotensive fractions has revealed its adverse effects on heart, liver and kidneys of mice at the dose of 1000 mg/kg/d.
