1.
Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives.
Farmaco
; 58(9): 631-7, 2003 Sep.
Article
in English
| MEDLINE
| ID: mdl-13679155
ABSTRACT
[5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed an interesting activity against a strain of Mycobacterium tuberculosis H(37)Rv and three clinical isolates of M. tuberculosis.
Subject(s)
Antitubercular Agents/chemical synthesis , Hydrazines/chemical synthesis , Thiazoles/chemical synthesis , Antitubercular Agents/chemistry , Antitubercular Agents/pharmacology , Hydrazines/chemistry , Hydrazines/pharmacology , Mycobacterium tuberculosis/drug effects , Structure-Activity Relationship , Thiazoles/chemistry , Thiazoles/pharmacology
2.
Farmaco
; 58(4): 315-22, 2003 Apr.
Article
in English
| MEDLINE
| ID: mdl-12727541
ABSTRACT
(+/-)-1-(5-Aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives were synthesized and tested for their in vitro antifungal activity. The compounds showed a moderate activity against strains of Candida parapsilosis, Candida pseudotropicalis and Candida glabrata.
