Chronic Low Back Pain: Prevalence, Impact on Quality of Life, and Predictors of Future Disability.

BACKGROUND: In primary healthcare settings, chronic low back pain (cLBP) is a widespread health issue with a great global impact. METHODS: A cross-sectional analytical study was performed on 918 adults attending primary healthcare settings in Makkah, Saudi Arabia, to estimate the cLBP prevalence, its effect on health-related quality of life (QOL), and predictors of subsequent disability. The visual analog scale of pain (VAS), World Health Organization Quality of Life Scale (WHO-QOL), and Oswestry low back pain disability index (ODI) were used to assess back pain severity, impact on QOL, and physical disability, respectively. RESULTS: The prevalence of cLBP among adults attending primary care settings in Makkah City was 25.9%, and 88.6% of them had a limited range of motion of the spine. About 58.1% had abnormal radiological findings detected by MRI. Based on the VAS scale, most patients (83.8%) had mild pain. The median (IQR) QOL score was 70 (60-80). Minimal and moderate disability scores were prevalent among 16.2% and 65.7% of patients, respectively. Disability scores were independently predicted by a lower QOL score (beta = -0.39, 95%CI = -0.49 to -0.29, p < 0.001) and higher VAS scores (beta = 0.47, 95%CI = 0.38-0.56, p < 0.001). Furthermore, disability was independently associated with having post-void residual volume (PVRV) (beta = 5.84, 95%CI = 1.97-9.72, p = 0.004) and abnormal X-ray findings (beta = 7.10, 95%CI = 1.77-12.4, p = 0.010). CONCLUSION: cLBP is common among adults attending primary care settings in Makkah City; it is associated with moderate disability and lower health-related QOL.

Cross-cultural adaptation and validation of the Italian Spine Youth Quality of Life (ISYQOL) questionnaire's Arabic version.

ABSTRACT: Health-related quality of life (HRQOL) assessment is considered among the most relevant outcome measures following conservative and surgical interventions for various spinal conditions. Several questions are available to evaluate HRQOL in these conditions. A more recent Italian Spine Youth Quality of Life (ISYQOL) questionnaire was developed for this purpose and showed high validity in measuring HRQOL.To translate and adapt the ISYQOL questionnaire into Arabic language (ISYQOL-Ar) and evaluate its validity and reliability, and to correlate it with the validated revised Scoliosis Research Society (SRS-22r)'s Arabic questionnaire in a cross-sectional multicenter study.The ISYQOL was translated, back-translated, and reviewed by an expert committee. Reliability assessment for the questionnaire domains was performed using Cronbach's alpha. For construct validation, the Pearson's correlation coefficient was used.A total of 115 patients were enrolled in the study and completed the ISYQOL-Ar and Arabic SRS-22r questionnaires. A total of 72 patients (63%) completed the first set of questionnaires, and 2 weeks later, 63 patients (55%) completed both sets of questionnaires, with 15.8 a mean age, 39.5° mean Cobb angle of 88.9% females. ISYQOL-Ar showed excellent validity, good reliability, and internal consistency for spine health and brace wear, with Cronbach's alpha > 0.6, similar to SRS-22r in the same cohort. The correlation was significant between ISYQOL-Ar and Arabic SRS-22r (Pearson's coefficient = 0.708, P < .001).The ISYQOL-Ar questionnaire is a reliable and valid outcome measure for the assessment of young patients with spinal deformity among the Arabic-speaking population.

How Do Pelvic Parameters Correlate With Postoperative Outcomes When the Parameters Are Not Measured Preoperatively in Patients Undergoing Instrumented Lumbar Fusion?

OBJECTIVE: A normal age-adjusted sagittal alignment is an important factor in achieving long-term functional results after lumbar spinal fusion. We aim to determine if the changes in spino-pelvic alignment (SPA) correlate with post-operative functional outcomes in patients who underwent instrumented lumbar spine surgery when the parameters were not measured before. METHOD: A retrospective review of medical records from 2012 to 2016, and radiographs of the patients who underwent instrumented fusion of the lumbar spine. The X-rays of the available preoperative lumbar spine were reviewed for SPA and compared with the last follow-up postoperative images. The patients were contacted by telephone to complete the EuroQoL 5 Dimensions 5-level questionnaire and visual analog scale for evaluation of their functional outcomes during 2017. Correlation studies were performed using Pearson's coefficient. RESULTS: Forty-six patients were included with a mean age of 53 years and a follow-up of 47 months. There was a significant improvement in the functional outcomes and pain in the whole group. All the patients showed improvement in their SPA, and those who underwent more than two levels of fusion showed a significant improvement (P<0.05). Lumbar lordosis and sacral slope had a significant correlation with postoperative clinical improvement (R=0.8). CONCLUSION: The study showed that single or double fusion has significant improvement in pain and functional outcome with a significant change in SPA.

Genetic influence of vitamin D receptor gene polymorphisms on osteoporosis risk.

OBJECTIVE: Osteoporosis is the most common type of bone disorder characterized by low bone mineral density (BMD). It is a multifactorial disease and caused by the interaction of environmental and genetic factors. It has been reported that mutations in the vitamin D receptor (VDR) gene highly affect the metabolism of minerals, which reduces bone density. Therefore, this study aimed to determine the association of VDR gene polymorphisms TaqI (rs731236) and ApaI (rs7975232) with osteoporosis risk in the Saudi population. METHODS: This case-control study involved 73 individuals with osteoporosis and 73 healthy controls in Jeddah, KSA. DNA extracted from peripheral blood was used to determine the genotypes and allele frequencies of VDR variants by polymerase chain reaction-restriction fragment length polymorphisms. Osteoporosis was confirmed by measuring BMD using dual-energy X-ray absorptiometry. The results were interpreted using the Hardy-Weinberg equilibrium assumption with P < 0.05 considered as significant. RESULTS: A significant increase in the genotype frequencies of the ApaI (Aa) and (aa) was observed among osteoporotic patients compared to controls (P = 0.002 and P < 0.0001, respectively). Only the homozygous (tt) genotype of TaqI was significantly higher in those with osteoporosis than in the controls (P = 0.001). The minor "a" allele of ApaI and the "t" allele of TaqI were significantly more common in the patients as compared to controls (P < 0.0001 and P = 0.01, respectively). CONCLUSION: VDR polymorphisms ApaI and TaqI were found to be significantly determinant risk factors for osteoporosis progression in the Saudi population.

Awareness of common paediatric orthopaedic problems among paediatricians and family medicine physicians.

BACKGROUND: Most paediatric orthopaedic problems referred to paediatric orthopaedists are usually self-limited, requiring observation and reassurance. Higher parental expectations may have resulted in higher referral rates. This study was conducted to assess awareness and knowledge about the diagnosis and management of some common normal variants of musculoskeletal paediatric development among paediatricians and primary health care physicians. METHOD: A self-administered questionnaire (tested for validity and reliability) was distributed between November 2016 and June 2017. Of 300 questionnaires, 189 (63% response rate) were obtained from 106 paediatricians, 57 family physicians, and 26 general practitioners (GPs). RESULTS: Paediatricians accounted for 56% of participants, 30.2% were family physicians, and 13.8% were GPs. Correct answer rates ranged between 9% and 66.1%. Inadequate knowledge of common paediatric orthopaedic problems was found in 87.3% of participants. With parental insistence, 75.7% of physicians referred a case, regardless of necessity, whereas inappropriate referral for medicolegal issues was reported by 62.4%. The study showed that paediatricians were less likely than family physicians and GPs to refer inappropriately (67% versus 87.7% and 84.6%, respectively; p = 0.007). Physicians who reported that more than 10% of their training was in orthopaedics were more likely to inappropriately refer orthopaedic cases compared to those who reported a higher percentage of orthopaedic training (82.1% versus 66.7%). CONCLUSION: Inappropriate paediatric orthopaedic referrals are increasing. The results clearly point to the need for increased musculoskeletal education during undergraduate medical and residency training in paediatrics and family medicine. New guidelines should be implemented and updated regularly. Educational material for parents (posters, videos, etc.) should be considered.

Computed Tomography Lung Volume Changes After Surgical Treatment for Early-Onset Scoliosis.

STUDY DESIGN: Single-center review of prospectively collected data. OBJECTIVES: To document anatomic lung volume and thoracic parameter changes in early-onset scoliosis patients undergoing rib-based (RB), or spine-based (SB) distraction surgical treatment who were too young to perform pulmonary function tests. METHODS: Twenty patients undergoing growth-sparing treatment had computed tomography lung volumes (CTvol) determined by controlled-ventilation CT scanning preoperatively and at a mean of 2.7 years later under an institutional review board (IRB)-approved protocol. Twelve patients had non-congenital curves and 8 had congenital curves. Eleven patients had SB constructs and 9 had RB ones. Computed tomography lung volumes were correlated to T1-12 length, T6 coronal width, pelvic width, and curve magnitude, and were normalized by comparison with age standards and pelvic width. RESULTS: All patients had increased CTvol at follow-up (RB 51%, SB 46%; p < .001). All increased T1-12 length from 128 mm (range, 39-160 mm) preoperatively to 154 mm (range, 61-216 mm) at follow-up. Both RB and SB gained 2.6 cm; this measurement was significant in RB (p < .001) owing to the shorter preoperative length. The T1-12 length correlated well with CTvol preoperatively (p = .002) and at follow-up (p = .007). The T6 width correlated best with CTvol (r = 0.76; p < .001 preoperatively and at follow-up). Main thoracic curves improved 21° in SB (preoperatively, 78°) versus 1.5° correction in RB (preoperatively, 60.2°). There was no correlation between curve magnitude and CTvol preoperatively or at follow-up. Follow-up CTvol percentile decreased in 10 patients, increased in 6, and was unchanged in 4. The T1-12 length was less than the fifth percentile in all patients preoperatively and increased in 9 patients at follow-up, whereas 11 remained at less than the fifth percentile. CONCLUSIONS: The CTvol quantitates anatomic results of early-onset scoliosis growth-sparing surgery in patients too young for standard pulmonary function tests. Thoracic length and width correlate well with absolute CTvol and are possible surrogate measures. Curve magnitude and correction correlate poorly and assume less importance in outcome evaluation. Thoracic volume and length gains exceeded normal growth in about half of the patients.

The value of adding posterior interbody fusion in the surgical treatment of degenerative lumbar spine disorders: A systematic review.

BACKGROUND: Posterolateral fusion (PF) is a common method by which to achieve fusion in lumbar spine surgery. It has been reported that posterior interbody fusion (PIF) yields a higher fusion rate and a better functional and clinical outcome. Our objective was to determine whether PIF improves the clinical and radiologic outcomes in adults surgically treated for degenerative lumbar spine conditions compared with PF. METHODS: We performed a systematic search of electronic databases, bibliographies, and relevant journals and meta-analyses. RESULTS: Of 2798 citations identified, 5 studies met our inclusion criteria (none of which was a randomized controlled trial), with a total of 148 patients in the PIF group (intervention) and 159 in the PF group (control). Pooled meta-analyses showed that nonunion rates were lower in the intervention group (relative risk, 0.22; 95% confidence interval [CI], 0.08-0.62). The intervention group had a significantly higher disc height (weighted mean difference, 3.2 mm; 95% CI, 1.9-4.4 mm) and lower residual percent slippage (weighted mean difference, 6.3%; 95% CI, 3.9%-8.7%) at final follow-up. There were no significant differences in segmental or total lumbar lordosis. Because of heterogeneity of results, no conclusions could be made with regard to functional benefits. CONCLUSIONS: This review suggests that PIF achieves a higher fusion rate and better correction of certain radiographic aspects of deformity over PF. It also showed a slight but not significant trend toward a better functional outcome in the PIF group. The lack of randomized controlled trials and the methodologic limitations of the available studies call for the planning and conduct of a sufficiently sized, methodologically sound study with clinically relevant outcome measures. Until this has been done, the current evidence regarding the beneficial effects of PIF should be interpreted with caution.

Functional outcome after proximal humeral fractures treated with hemiarthroplasty.

OBJECTIVE: To evaluate functional outcome after hemiarthroplasty for displaced proximal humeral fractures and to review whether prosthesis type, intraoperative technique or previous ipsilateral shoulder surgery could affect the outcome. METHODS: We reviewed the medical records and radiographs of patients who had undergone hemiarthroplasty for proximal humeral fractures between 1992 and 2000. We identified 45 patients, 39 with acute fractures and 6 with fracture-related complications. One surgeon performed 17 surgeries (38%), and the rest were carried out by 11 other orthopedic surgeons. Using the American Shoulder and Elbow Surgeons Evaluation Form and the Western Ontario Rotator Cuff Index, we evaluated patients who had been followed for at least 2 years for residual shoulder pain, range of motion, strength, stability and function. The senior authors reviewed the radiographs. RESULTS: The mean age of the patients at presentation was 70 (range 46-95) years. The mean active forward elevation was 87 degrees, abduction 63 degrees and external rotation 22 degrees; the mean internal rotation was to the L2 vertebra. Of the patients, 15% reported severe pain, and 25% were unable to sleep on the affected side. Patients with previous surgeries and those with intraoperative cuff tears were found to have more postoperative pain. CONCLUSION: We conclude that soft tissue status and operative technique play an important role in late postoperative pain and range of motion. Hemiarthroplasty after failed open reduction and internal fixation is associated with inferior results. We were unable to show a difference in long-term outcome related to the prosthesis type.

The surgical management of degenerative lumbar spondylolisthesis: a systematic review.

STUDY DESIGN: Systematic review. OBJECTIVE: To identify whether there is an advantage to instrumented or noninstrumented spinal fusion over decompression alone for patients with degenerative lumbar spondylolisthesis. SUMMARY OF BACKGROUND DATA: The operative management of degenerative spondylolisthesis includes spinal decompression with or without instrumented or noninstrumented spinal fusion. Evidence on the operative management of degenerative spondylolisthesis is still divisive. METHODS: Relevant RCT and comparative observational studies between 1966 and June 2005 were identified. Abstracted outcomes included clinical outcome, reoperation rate, and solid fusion status. Analyses were separated into: 1) fusion versus decompression alone and 2) instrumented fusion versus noninstrumented fusion. RESULTS: Thirteen studies were included. The studies were generally of low methodologic quality. A satisfactory clinical outcome was significantly more likely with fusion than with decompression alone (relative risk, 1.40; 95% confidence interval, 1.04-1.89; P < 0.05). The use of adjunctive instrumentation significantly increased the probability of attaining solid fusion (relative risk, 1.37; 95% confidence interval, 1.07-1.75; P < 0.05), but no significant improvement in clinical outcome was recorded (relative risk, 1.19; 95% confidence interval, 0.92-1.54). There was a nonsignificant trend toward lower repeat operations with fusion compared with both decompression alone and instrumented fusion. CONCLUSION: Spinal fusion may lead to a better clinical outcome than decompression alone. No conclusion about the clinical benefit of instrumenting a spinal fusion could be made. However, there is moderate evidence that the use of instrumentation improves the chance of achieving solid fusion.