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1.
Vet J ; 202(3): 573-7, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25257351

ABSTRACT

The combination of an angiotensin-converting enzyme inhibitor (ACEI) with an aldosterone receptor antagonist can increase serum potassium and magnesium and lower serum sodium concentrations. The objective of this study was to retrospectively determine whether an ACEI and spironolactone can be co-administered to Doberman pinschers with occult dilated cardiomyopathy without serious adverse influences on serum electrolyte concentrations. Between 2001 and 2007, 26 client-owned Doberman pinschers were given enalapril, spironolactone, and carvedilol and followed for at least 6 months. Most dogs had been prescribed mexiletine for ventricular tachyarrhythmia suppression. Dogs were treated with pimobendan when congestive heart failure was imminent. Baseline and follow-up (3-10 visits) color-flow Doppler echocardiograms, serum urea nitrogen (SUN), creatinine, sodium, potassium, and magnesium concentration data were tabulated. Compared to baseline data, there were no significant changes in serum sodium or serum creatinine concentrations. Serum magnesium (P = 0.003), serum potassium (P = 0.0001), and SUN (P = 0.0001) concentrations increased significantly with time. Although the combination of ACEI and spironolactone was associated with significant increases in magnesium, potassium, and SUN concentrations, these changes were of no apparent clinical relevance. At the dosages used in this study, this combination of drugs appears safe.


Subject(s)
Angiotensin-Converting Enzyme Inhibitors/adverse effects , Cardiomyopathy, Dilated/veterinary , Dog Diseases/drug therapy , Electrolytes/blood , Enalapril/adverse effects , Mineralocorticoid Receptor Antagonists/adverse effects , Spironolactone/adverse effects , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Animals , Cardiomyopathy, Dilated/drug therapy , Cohort Studies , Dogs , Drug Combinations , Enalapril/administration & dosage , Female , Male , Mineralocorticoid Receptor Antagonists/administration & dosage , Retrospective Studies , Species Specificity , Spironolactone/administration & dosage
2.
J Vet Intern Med ; 23(1): 1-6, 2009.
Article in English | MEDLINE | ID: mdl-19175714

ABSTRACT

BACKGROUND: Asymptomatic Doberman Pinschers with dilated cardiomyopathy (DCM) often die suddenly owing to ventricular tachycardia that degenerates into ventricular fibrillation. A safe and effective antiarrhythmic drug treatment is needed. This will require a large, well-controlled, prospective study. HYPOTHESIS: Amiodarone toxicity is common in Dobermans with occult DCM and ventricular tachyarrhythmias refractory to antiarrhythmia therapy. Infrequent monitoring of hepatic function is inadequate. Frequent monitoring may be useful to determine dogs in which the dosage should be decreased or the drug withdrawn. METHODS: Medical records from the University of Georgia and Cornell University were searched for Doberman Pinschers diagnosed with preclinical DCM that received amiodarone for severe ventricular arrhythmias refractory to other antiarrhythmic agents. Echocardiographic data, Holter recording data, hepatic enzyme serum activity, and serum amiodarone concentrations were recorded. The presence of clinical signs of toxicity was recorded. Serum amiodarone concentrations were obtained in some dogs. RESULTS: Reversible toxicity was identified in 10 of 22 (45%) dogs. CONCLUSION AND CLINICAL IMPORTANCE: Adverse effects from amiodarone were common and were, in part, dosage related. Patients should be monitored for signs of toxicity and liver enzyme activity should be measured at least monthly.


Subject(s)
Amiodarone/adverse effects , Anti-Arrhythmia Agents/adverse effects , Cardiomyopathy, Dilated/veterinary , Dog Diseases/drug therapy , Tachycardia, Ventricular/veterinary , Amiodarone/administration & dosage , Amiodarone/therapeutic use , Animals , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/therapeutic use , Cardiomyopathy, Dilated/drug therapy , Chemical and Drug Induced Liver Injury , Dog Diseases/chemically induced , Dogs , Dose-Response Relationship, Drug , Female , Liver Diseases/veterinary , Male , Retrospective Studies , Tachycardia, Ventricular/drug therapy
3.
J Vet Intern Med ; 23(1): 39-42, 2009.
Article in English | MEDLINE | ID: mdl-19175718

ABSTRACT

BACKGROUND: Calcium channel blocking drugs, usually nifedipine and less often amlodipine, have been reported to cause gingival hyperplasia (GH) in humans. HYPOTHESIS: Amlodipine, a dihydropyridine calcium channel blocking drug, can cause GH when administered chronically to older small dogs with degenerative valvular disease. ANIMALS STUDIED: From January 2004 to May 2008, 82 client-owned dogs with degenerative valvular disease and left atrial dilatation were treated with amlodipine in combination with spironolactone and enalapril and followed for >6 months. METHODS: Retrospective study. A chronological observation of GH in 2 dogs treated with amlodipine in 2004 and 2006 prompted the study. Patient histories and medical records of each dog treated with amlodipine for degenerative valvular disease from January 2004 to May 2008 were reviewed. RESULTS: GH was observed by clients and the authors in 7 of 82 (8.5%) dogs. Histologic confirmation of the diagnosis was made in 2 dogs. The minimum duration of treatment before diagnosis of GH was 5 months. GH began to resolve within 2 weeks of discontinuing amlodipine and resolution was complete within 6 months. Amlodipine administration was reinstituted in 1 dog in which GH had resolved, and GH reoccurred within 4 months. CONCLUSION AND CLINICAL IMPORTANCE: Long-term administration of amlodipine to dogs with degenerative valvular disease may cause GH in a small percentage of patients. GH resolves quickly after withdrawal of amlodipine treatment.


Subject(s)
Amlodipine/adverse effects , Amlodipine/therapeutic use , Dog Diseases/drug therapy , Gingival Hyperplasia/veterinary , Heart Valve Diseases/veterinary , Amlodipine/administration & dosage , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Animals , Calcium Channel Blockers/adverse effects , Calcium Channel Blockers/therapeutic use , Diuretics/administration & dosage , Diuretics/therapeutic use , Dogs , Enalapril/administration & dosage , Enalapril/therapeutic use , Female , Gingival Hyperplasia/chemically induced , Heart Valve Diseases/drug therapy , Male , Retrospective Studies , Spironolactone/administration & dosage , Spironolactone/therapeutic use
4.
J Vet Intern Med ; 22(4): 931-6, 2008.
Article in English | MEDLINE | ID: mdl-18537877

ABSTRACT

BACKGROUND: Syncope is a recognized problem in Boxers and often is the result of rapid ventricular tachycardia (VT). Affected dogs may have echocardiographic evidence of dilated cardiomyopathy, but frequently have normal echocardiograms. Although VT is probably the most common cause of syncope in Boxers, neurocardiogenic bradycardia can also occur. OBJECTIVE: We describe 7 Boxers with comorbid VT and neurocardiogenic bradycardia, wherein the syncope was secondary to bradycardia rather than VT. ANIMALS: Seven Boxers were selected from a larger population of Boxers with Holter-documented VT because these dogs had documented bradycardia at the time of syncope. METHODS: Retrospective study. RESULTS: Although all dogs had Holter-documented VT, the etiology of the syncopal episodes was consistent with neurocardiogenic bradycardia. CLINICAL IMPORTANCE: Neurocardiogenic bradycardia or VT can occur as isolated problems in Boxers. In some Boxers, VT and potential or manifest neurocardiogenic bradycardia coexist. The administration of a beta-blocker or sotalol to such dogs can aggravate or precipitate neurocardiogenic bradycardia-related syncope.


Subject(s)
Bradycardia/veterinary , Dog Diseases/etiology , Syncope/veterinary , Tachycardia, Ventricular/veterinary , Animals , Bradycardia/complications , Dogs , Male , Syncope/etiology , Tachycardia, Ventricular/complications
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