Perceived chronic social adversity and cyberbullying perpetration among adolescents: the mediating role of rumination and moderating role of mindfulness.

Backgrounds: The prevalence of cyberbullying has brought about many adverse effects on adolescents' mental health. Although current studies have shown that perceived chronic social adversity (PCSA) is closely related to cyberbullying perpetration among adolescents, the underlying mechanism of the relationship between the two remains relatively unclear. This study investigated the association of PCSA, rumination, mindfulness, and cyberbullying perpetration among adolescents, building upon the general strain theory, the general aggressive model, and the limited resource of self-control theory. Methods: A sample of 477 Chinese high school students (M age = 15.84 years, SD age = 0.67, 49.69% female) completed the Perceived Chronic Social Adversity Questionnaire, the Ruminative Responses Scale, the Child and Adolescent Mindfulness Measure, and the cyberbullying subscale of the Revised Cyber Bullying Inventory. The current study constructed a moderated mediation model to examine the relationship between PCSA and cyberbullying perpetration among adolescents and assessed the mediating role of rumination and the moderating role of mindfulness. Results: The results revealed a significant positive correlation between PCSA and cyberbullying perpetration. Rumination mediated the relationship between PCSA and cyberbullying perpetration, whereas mindfulness moderated the latter half of the mediation pathway. Specifically, compared to adolescents with higher mindfulness, the association between rumination and cyberbullying perpetration is greater for adolescents with lower mindfulness. Conclusion: The results further deepen our understanding of the mechanisms linking subjective perception of negative life events and cyberbullying perpetration among adolescents from the interaction of multiple factors, thus providing a basis for future interventions to encourage adolescents to properly cope with social adversity and promote positive mental health to reduce the risk of cyberbullying.

The Association between Cyberbullying Victimization and Depression among Children: A Moderated Mediation Model.

Cyberbullying victimization is becoming more prevalent and adversely affects mental health. This research explores the relationship between the two variables and the underlying mechanism, especially for children, as the impact of mental health in childhood might last a lifetime. Primary school students (N = 344; Mage = 9.90; 43.90% girls) completed self-report questionnaires regarding cyberbullying victimization, self-perceived social competence, optimism, and depression at school. Gender and grade were controlled as covariates. Depression was positively predicted by cyberbullying victimization, while self-perceived social competence played a partially mediating role. In addition, optimism directly and indirectly moderated the effects of cyberbullying victimization on depression. Specifically, the effects were stronger for children with low levels of optimism. Therefore, efforts to enhance children's self-perceived social competence and optimism may reduce their depression resulting from cyberbullying victimization.

Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice.

Cognitive and behavioral rigidity are observed in various psychiatric diseases, including in autism spectrum disorder (ASD). However, the underlying mechanism remains to be elucidated. In this study, we found that neuroligin-3 (NL3) R451C knockin mouse model of autism (KI mice) exhibited deficits in behavioral flexibility in choice selection tasks. Single-unit recording of medium spiny neuron (MSN) activity in the nucleus accumbens (NAc) revealed altered encoding of decision-related cue and impaired updating of choice anticipation in KI mice. Additionally, fiber photometry demonstrated significant disruption in dynamic mesolimbic dopamine (DA) signaling for reward prediction errors (RPEs), along with reduced activity in medial prefrontal cortex (mPFC) neurons projecting to the NAc in KI mice. Interestingly, NL3 re-expression in the mPFC, but not in the NAc, rescued the deficit of flexible behaviors and simultaneously restored NAc-MSN encoding, DA dynamics, and mPFC-NAc output in KI mice. Taken together, this study reveals the frontostriatal circuit dysfunction underlying cognitive inflexibility and establishes a critical role of the mPFC NL3 deficiency in this deficit in KI mice. Therefore, these findings provide new insights into the mechanisms of cognitive and behavioral inflexibility and potential intervention strategies.

Empathy and bystander helping behavior in cyberbullying among adolescents: the mediating role of internet moral judgment and the moderating role of internet self-efficacy.

Introduction: Cyberbullying poses a significant challenge among adolescents. If bystanders stand up and help victims, their helping behavior may be able to reduce the frequency and negative impact of cyberbullying. This study investigates the association of empathy, internet moral judgment, and internet self-efficacy with bystander helping behavior among adolescents, building upon the empathy-altruism hypothesis, bystander intervention model, and dual-process model of morality. Methods: A sample of 919 Chinese adolescents from 3 schools in Hunan, Jiangxi and Guangdong provinces completed the Basic Empathy Scale, Internet Moral Judgment Questionnaire, Internet Self-Efficacy Questionnaire and Styles of Bystander Intervention Scale. And we constructed a moderated mediation model to examine the relationship between empathy and bystander helping behavior in cyberbullying and assessed the mediating role of internet moral judgment and the moderating role of internet self-efficacy. Results: Our findings revealed a significant positive correlation between empathy and bystander helping behavior in cyberbullying. Internet moral judgment mediated the relationship between empathy and helping behavior, whereas internet self-efficacy moderated the latter half of the mediation pathway. Specifically, the association between internet moral judgment and helping behavior was stronger for bystanders with higher levels of internet self-efficacy compared with those that have lower levels. Discussion: These results further deepen our understanding of the mechanisms involved in bystander helping behavior in cyberbullying, thus providing a basis for future interventions to encourage more helping actions from bystanders during cyberbullying incidents.

Development and Validation of an Autonomy Questionnaire for Chinese Adolescents From the Perspective of Network Culture.

This study developed a measure of autonomy for adolescents in contemporary China. First, data from 44 interviewees-40 secondary school students, 2 parents, and 2 secondary school teachers-were used to explore the connotation and theoretical structure of autonomy in adolescents in China. Next, a preliminary Adolescent Autonomy Questionnaire was created from the interview data and administered to 775 secondary school students. Exploratory factor analysis and confirmatory factor analysis (CFA) were conducted to verify the factor structure. Finally, 614 secondary school students completed the Adolescent Autonomy Questionnaire, Personal Growth Initiative Scale-II, and Adolescence Ego Identity Crisis Scale to evaluate criterion validity. The final version of the Adolescent Autonomy Questionnaire included 16 items and four subscales: autonomous decision-making, autonomous regulation, autonomous protection, and autonomous problem-solving. The total variance of the cumulative interpretation questionnaire was 62.54%. The CFA results showed that the four-factor model fits the data well: χ 2/df = 2.340, CFI = 0.949, RMSEA = 0.042, SRMR = 0.046. Evaluation of the psychometric properties of the Adolescent Autonomy Questionnaire provided support for the reliability and validity of the measure. Thus, it serves as an effective measurement tool for assessing the autonomy of adolescents in China.

GRIN2A Variants Associated With Idiopathic Generalized Epilepsies.

Objective: The objective of this study is to explore the role of GRIN2A gene in idiopathic generalized epilepsies and the potential underlying mechanism for phenotypic variation. Methods: Whole-exome sequencing was performed in a cohort of 88 patients with idiopathic generalized epilepsies. Electro-physiological alterations of the recombinant N-methyl-D-aspartate receptors (NMDARs) containing GluN2A mutants were examined using two-electrode voltage-clamp recordings. The alterations of protein expression were detected by immunofluorescence staining and biotinylation. Previous studies reported that epilepsy related GRIN2A missense mutations were reviewed. The correlation among phenotypes, functional alterations, and molecular locations was analyzed. Results: Three novel heterozygous missense GRIN2A mutations (c.1770A > C/p.K590N, c.2636A > G/p.K879R, and c.3199C > T/p.R1067W) were identified in three unrelated cases. Electrophysiological analysis demonstrated R1067W significantly increased the current density of GluN1/GluN2A NMDARs. Immunofluorescence staining indicated GluN2A mutants had abundant distribution in the membrane and cytoplasm. Western blotting showed the ratios of surface and total expression of the three GluN2A-mutants were significantly increased comparing to the wild type. Further analysis on the reported missense mutations demonstrated that mutations with severe gain-of-function were associated with epileptic encephalopathy, while mutations with mild gain of function were associated with mild phenotypes, suggesting a quantitative correlation between gain-of-function and phenotypic severity. The mutations located around transmembrane domains were more frequently associated with severe phenotypes and absence seizure-related mutations were mostly located in carboxyl-terminal domain, suggesting molecular sub-regional effects. Significance: This study revealed GRIN2A gene was potentially a candidate pathogenic gene of idiopathic generalized epilepsies. The functional quantitative correlation and the molecular sub-regional implication of mutations helped in explaining the relatively mild clinical phenotypes and incomplete penetrance associated with GRIN2A variants.

Does bullying victimization really influence adolescents' psychosocial problems? A three-wave longitudinal study in China.

BACKGROUND: Traditional bullying and cyberbullying victimization are associated with adolescents' mental health problems, but the temporal sequence of these relations remains unclear. The present study analyzed the temporal and reciprocal relationships between both types of bullying victimization and six frequent psychosocial problems during adolescence: depression, general anxiety, stress, low self-esteem, social anxiety, and loneliness. METHODS: A total of 661 Chinese adolescents in grades 7 and 8 at the initial wave of the study responded to the survey items assessing their bullying victimization experiences and self-reported psychosocial problems. This research was conducted at three separate time points, over a year and a half period. RESULTS: Bullying victimization did not predict adolescents' psychosocial problems. Instead, adolescents with psychosocial problems were more likely to experience bullying victimization. Depression and general anxiety were two common predictors of traditional bullying and cyberbullying victimization. Stress was a specific predictor of traditional bullying victimization, whereas self-esteem, social anxiety, and loneliness were specific predictors of cyberbullying victimization. Psychosocial problems did not differentially predict the two types of bullying victimization. Boys with higher levels of loneliness were more likely than girls to experience cyberbullying victimization. LIMITATIONS: The present study is limited in terms of its sample selection and self-reported instruments. CONCLUSIONS: This study emphasizes adolescents' psychosocial problems as the potential risk factors for their future bullying victimization. Education professionals should pay special attention to adolescents' mental health problems when formulating bullying interventions and programs.

Are Narcissists More Likely to Be Involved in Cyberbullying? Examining the Mediating Role of Self-Esteem.

Although cyberbullying, a new type of aggressive behavior via electronic means, has been found to be strongly linked with individuals' personality characteristics, few studies to date have investigated its relationship with narcissism, especially overt and covert narcissism. The current study tested the associations between overt and covert narcissism on one hand and cyberbullying perpetration and victimization on the other. To explain these differences further, self-esteem was tested as a mediator through which the two types of narcissism may exert their influences on cyberbullying. An anonymous questionnaire was completed by 814 Chinese adolescents aged 11 to 18. Results of multiple regression analyses indicated that after controlling for gender and student status (middle or high school students), covert narcissism positively predicted both cyberbullying perpetration and victimization, whereas overt narcissism had no association with either perpetration or victimization. Furthermore, when gender and student status were controlled, self-esteem mediated the relationships between overt/covert narcissism and cyberbullying perpetration and victimization, highlighting the possibility that self-esteem is an explanatory mechanism for the associations between the two types of narcissism and cyberbullying. These findings suggest that interventions aimed at reducing engagement in cyberbullying may be more urgent and important for individuals with high levels of covert narcissism. Boosting self-esteem needs to be particularly highlighted in developing anti-bullying measures and policies.

Social networking site addiction and undergraduate students' irrational procrastination: The mediating role of social networking site fatigue and the moderating role of effortful control.

With the popularity of social networking sites (SNSs), the problems of SNS addiction have been increasing. Research has revealed the association between SNS addiction and irrational procrastination. However, the mechanism underlying this relation is still unclear. The present study aimed to examine the mediating role of social networking site fatigue and the moderating role of effortful control in this link among Chinese undergraduate students. The Social Networking Site Addiction Scale, Social Networking Service Fatigue Scale, Effortful Control Scale and Irrational Procrastination Scale were completed by 1,085 Chinese undergraduate students. Results indicated that SNS addiction, SNS fatigue and irrational procrastination were positively correlated with each other, and negatively correlated with effortful control. Further analyses revealed that, SNS addiction has a direct effect on irrational procrastination. SNS fatigue mediated the relationship between SNS addiction and irrational procrastination. Both direct and indirect effects of SNS addiction on irrational procrastination were moderated by effortful control. Specifically, this effect was stronger for people with lower effortful control. These findings help clarify the mechanism underlying the association between SNS addiction and irrational procrastination, which have potential implications for intervention.

Stability and Change of Bullying Roles in the Traditional and Virtual Contexts: A Three-Wave Longitudinal Study in Chinese Early Adolescents.

Traditional bullying and cyberbullying are two prevalent phenomena among adolescents around the world. Typically, bullying incidents involve distinct perpetrator and victim roles. However, the question whether participants' roles in bullying situation remain stable or changeable is unclear. The present study examined the developmental stability and change of bullying roles by simultaneously investigating adolescents' bullying behaviors both in the traditional and virtual contexts. Participants were 661 seventh- and eighth-grade students (39.0% girls) aged 11-15 years (M = 12.86, SD = .73) in China. They completed a survey measuring their experiences in perpetration and victimization of traditional bullying and cyberbullying at three time points with 6-month intervals. A cross-lagged panel design was used to test for the temporal sequence of research variables. The results showed a moderate consistency in the bullying roles that students took on (i.e., perpetrator and victim) over time. Traditional bullying perpetrators continued to bully others online, whereas cyberbullying victims continued to be bullied offline. Regarding role change in bullying, perpetrators and victims did not change their roles in traditional bullying situation, but they tended to change their roles to the opposites in cyberbullying situation. Traditional bullying victims were more likely to become cyberbullying perpetrators, and vice versa. Traditional bullying perpetrators also had a greater tendency of being bullied online, but not vice versa. The findings suggest that interventions aimed at reducing adolescents' bullying behaviors should focus on the stability and change of bullying roles in the traditional and virtual contexts.

Functional Investigation of a GRIN2A Variant Associated with Rolandic Epilepsy.

N-methyl-D-aspartate receptors (NMDARs), a subtype of glutamate-gated ion channels, play a central role in epileptogenesis. Recent studies have identified an increasing number of GRIN2A (a gene encoding the NMDAR GluN2A subunit) mutations in patients with epilepsy. Phenotypes of GRIN2A mutations include epilepsy-aphasia disorders and other epileptic encephalopathies, which pose challenges in clinical treatment. Here we identified a heterozygous GRIN2A mutation (c.1341T>A, p.N447K) from a boy with Rolandic epilepsy by whole-exome sequencing. The patient became seizure-free with a combination of valproate and lamotrigine. Functional investigation was carried out using recombinant NMDARs containing a GluN2A-N447K mutant that is located in the ligand-binding domain of the GluN2A subunit. Whole-cell current recordings in HEK 293T cells revealed that the N447K mutation increased the NMDAR current density by ~1.2-fold, enhanced the glutamate potency by 2-fold, and reduced the sensitivity to Mg2+ inhibition. These results indicated that N447K is a gain-of-function mutation. Interestingly, alternative substitutions by alanine and glutamic acid at the same residue (N447A and N447E) did not change NMDAR function, suggesting a residual dependence of this mutation in altering NMDAR function. Taken together, this study identified human GluN2A N447K as a novel mutation associated with epilepsy and validated its functional consequences in vitro. Identification of this mutation is also helpful for advancing our understanding of the role of NMDARs in epilepsy and provides new insights for precision therapeutics in epilepsy.