Hydroxychloroquine-induced pigmentation in rheumatic diseases: prevalence, clinical features and influencing factors.

OBJECTIVE: To describe the clinical features of Chinese patients with hydroxychloroquine (HCQ)-induced pigmentation and analyze the potential risk factors associated with HCQ-induced pigmentation. METHODS: A cross-sectional study was conducted over a duration of 7 months, during which patients who had received HCQ treatment for >6 months were included. Data was collected through a structured questionnaire that encompassed demographic and geographic characteristics, information on HCQ and concomitant medication usage, sun exposure characteristics, and hyperpigmentation-related characteristics. Univariate and multivariate analyses were employed to calculate the statistical association between HCQ-induced pigmentation and multiple variables. RESULTS: Out of 316 patients, 83 (26.3%) patients presented hyperpigmentation during HCQ treatment. Hyperpigmentation presented after a median duration of HCQ treatment of 12 months (interquartile range, 6.0 months-30.0 months) with a median cumulative dose of 108 g of HCQ (interquartile range, 36-288 g). The most frequently affected sites of pigmentation were the face (60.2%), lower limbs (36.1%), and hands (20.5%). There was a linear decrease in the incidence of pigmentation with increasing daily sun exposure time (p= 0.030). In the multivariate analysis, variables (cumulative HCQ dose and daily sun exposure time) were included in the final models. The results revealed an independent correlation between HCQ-induced pigmentation and daily sun exposure exceeding 1 h (OR: 0.431; 95%CI: 0.208-0.892; p= 0.023). CONCLUSIONS: The occurrence of HCQ-induced pigmentation is not uncommon, with an incidence rate of 26.3%. Daily sun exposure time exhibited a protective effect against HCQ-induced pigmentation.

Effect of respiratory muscle training in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis.

Objectives: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder characterized by progressive airflow limitation. This meta-analysis aims to evaluate the effectiveness of respiratory muscle training (RMT) on key pulmonary function parameters, inspiratory muscle strength and quality of life in patients with stable COPD. Methods: A comprehensive search was conducted in the databases including PubMed, Cochrane, Web of Science, Embase, and ClinicalTrials.gov, from their inception to June 12, 2023. Randomized controlled trials (RCTs) evaluating the impact of RMT on stable COPD were included for meta-analysis. Results: In total, 12 RCTs involving 453 participants were included in the meta-analysis. RMT demonstrated a significant increase in maximal inspiratory pressure (PImax, MD, 95% CI: 14.34, 8.17 to 20.51, P < 0.001) but not on maximal expiratory pressure (PEmax). No significant improvement was observed in 6-Min walk test (6MWT), dyspnea, forced expiratory volume in 1 s (FEV1), forced vital capacity ratio (FVC) and quality of life between RMT and control groups. However, subgroup analysis revealed a significant negative effect of RMT alone on FEV1/FVC (MD, 95% CI: 2.59, -5.11 to -0.06, P = 0.04). When RMT was combined with other interventions, improvements in FEV1/FVC and FEV1 were found, although not statistically significant. Conclusion: RMT can effectively improve maximal inspiratory pressure in stable COPD patients, but the effect is slight in improving lung function, dyspnea and quality of life. It is recommended to combine with other treatment strategies to comprehensively improve the prognosis of COPD patients.

A recyclable SERS-DGT device for in-situ sensing of sulfamethazine by Au@g-C3N4NS in water.

Although diffusion gradient in thin-film technique (DGT) has realized the in-situ sampling Sulfamethazine (SMT), the traditional DGT devices cannot be served as sensing devices but in-situ sampling devices. Here we report a recyclable surface enhanced Raman scattering (SERS) responsive DGT sensing device (recyclable SERS-DGT Sensing Device) capable of in-situ sensing of SMT in water. This is achieved by innovatively utilizing a recyclable SERS responsive liquid suspension of Au nanoparticles supported on g-C3N4 (Au@g-C3N4NS) as DGT binding phase. Au@g-C3N4NS is synthesized via in-situ growth method and embed in DGT binding phase, which exhibits good SERS activity, aqueous stability recyclable and adsorption performance. The SERS-DGT Sensing Device is valid for measuring SMT under a wide range of conditions (i.e., deployment time 24∼180 h, concentrations range of 1.031∼761.9 ng mL-1, pH 5∼9, ionic strength 0.0001∼0.05 mol L-1 NaCl, DOM concentrations 0∼100 mg L-1, four recycles). Furthermore, substrate combined with DGT binding phase, can integrate the sampling, pretreatment and SERS detection of SMT, which can be recycled, improving the reliability and efficiency of environmental monitoring. In this article, recyclable SERS-DGT Sensing Device, a platform for recyclable in-situ sensing of antibiotics, holds great potential for environmental monitoring.

Stability Analysis of Fractional Bidirectional Associative Memory Neural Networks With Multiple Proportional Delays and Distributed Delays.

This article investigates the finite-time stability of a class of fractional-order bidirectional associative memory neural networks (FOBAMNNs) with multiple proportional and distributed delays. Different from the existing Gronwall integral inequality with single proportional delay ( N = 1 ), we establish the Gronwall integral inequality with multiple proportional delays for the first time in the case of N ≥ 2 . Since the existing fractional-order single-constant delay Gronwall inequality with two different orders cannot be directly applied to the stability analysis of the aforementioned system, initially, we skillfully develop a novel one with generalized fractional multiproportional delays' Gronwall inequalities of different orders. Furthermore, combined with the newly constructed generalized inequality, the stability criteria of FOBAMNNs with fractional orders and under weaker conditions, i.e., at most linear growth and linear growth conditions rather than the global Lipschitz condition, are given respectively. Finally, numerical experiments verify the effectiveness of the proposed method.

A SERS Responsive DGT Sensing Device for On-Site Determination of Organic Contaminants Underwater.

Although diffusion gradient in the thin-film technique (DGT) is highly regarded in environmental analysis, the traditional DGT devices cannot serve as sensing devices but in situ sampling devices. Here we report a surface enhanced Raman scattering (SERS) responsive DGT sensing device (SERS-DGT Sensor) capable of on-site determination of organic contaminants underwater. This is achieved by innovatively utilizing a SERS responsive liquid suspension of Au nanoparticles supported on graphene oxide (AuNPs@GO) as the DGT binding phase. Liquid suspension is synthesized via a combined secondary growth and molecular welding approach and used as DGT binding phase AuNPs@GO exhibit good SERS activity, aqueous stability, and adsorption performance. Based on the development time range of 24-144 h, the measurement of sulfadiazine (SMT) by SERS-DGT Sensor is evaluated in the concentration range of 0.3289-2631 ng mL-1. The SERS-DGT sampler is valid for measuring SMT under a wide range of environmental conditions (i.e, pH 5-9, ionic strength 0.0001-0.05 mol L-1 NaCl, DOM concentrations 0-100 mg L-1, the values of TC: SMT ≤ 20 and MNZ: SMT ≤ 20). SERS-DGT Sensor is applied to the practical test of SMT content in pig breeding wastewater, and compared with the grab sampling method, the results confirm that this novel hyphenated technique exhibits good accuracy and precision. The platform proves to be versatile by extending the method to the monitoring of rhodamine 6G, metronidazole, fluoxetine, and enrofloxacin. In this article, SERS-DGT Sensor, a platform for directly on-site sensing of organic DGT, holds great potential for in situ sampling and on-site sensing for a wide range of organics and provides a new idea for environmental monitoring.

Tensor Recovery Based on a Novel Non-Convex Function Minimax Logarithmic Concave Penalty Function.

Non-convex relaxation methods have been widely used in tensor recovery problems, compared with convex relaxation methods, and can achieve better recovery results. In this paper, a new non-convex function, Minimax Logarithmic Concave Penalty (MLCP) function, is proposed, and some of its intrinsic properties are analyzed, among which it is interesting to find that the Logarithmic function is an upper bound of the MLCP function. The proposed function is generalized to tensor cases, yielding tensor MLCP and weighted tensor Lγ -norm. Consider that its explicit solution cannot be obtained when applying it directly to the tensor recovery problem. Therefore, the corresponding equivalence theorems to solve the such problem are given, namely, tensor equivalent MLCP theorem and equivalent weighted tensor Lγ -norm theorem. In addition, we propose two EMLCP-based models for classic tensor recovery problems, namely low-rank tensor completion (LRTC) and tensor robust principal component analysis (TRPCA), and design proximal alternate linearization minimization (PALM) algorithms to solve them individually. Furthermore, based on the Kurdyka-Åasiwicz property, it is proved that the solution sequence of the proposed algorithm has a finite length and converges to the critical point globally. Finally, extensive experiments show that the proposed algorithm achieves good results, and it is confirmed that the MLCP function is indeed better than the Logarithmic function in the minimization problem, which is consistent with the analysis of theoretical properties.

Flexible stretchable low-energy X-ray (30-80 keV) radiation shielding material: Low-melting-point Ga1In1Sn7Bi1 alloy/thermoplastic polyurethane composite.

A highly flexible stretchable thermoplastic polyurethane (TPU) composite loaded with a low-melting-point Ga1In1Sn7Bi1 multiprincipal element alloy (LMPEA) was prepared, and its radiation shielding performance was evaluated. The fluid characteristic of LMPEA and the flexibility of TPU enable good interface compatibility. Ga1In1Sn7Bi1 LMPEA consists of two eutectic structures, and the liquid gallium-rich phases are distributed at the boundary of the InBi intermetallic compound and Sn solid solution. In the low-photon energy range of 30-80 keV, LMPEA has a theoretical specific lead equivalent of 0.803 mmPb/mm and a theoretical weight reduction of 17.27% compared with lead. To evaluate the photon attenuation capability for the LMPEA/TPU composites, the Phy-X procedure and Monte Carlo simulations were used to determine the shielding parameters, such as the mass attenuation coefficient, linear attenuation coefficient, half-value layer, tenth-value layer, mean free path, effective atomic number, and fast neutron removal cross section. The attenuation performance test of X-ray protective materials measured the actual lead equivalent. At the same thickness, the LMPEA/TPU composite (66.667, 50.000 wt% LMPEA loading) has a higher measured lead equivalent than the in-service medical shielding materials, which meets the lead equivalent requirements of X-ray protective clothing. LMPEA/TPU composites are nontoxic, lightweight, and have excellent low-energy X-ray shielding ability, offering great potential for application in medical wearable materials.

Single-cell RNA sequencing reveals intrahepatic and peripheral immune characteristics related to disease phases in HBV-infected patients.

OBJECTIVE: A comprehensive immune landscape for HBV infection is pivotal to achieve HBV cure. DESIGN: We performed single-cell RNA sequencing of 2 43 000 cells from 46 paired liver and blood samples of 23 individuals, including six immune tolerant, 5 immune active (IA), 3 acute recovery (AR), 3 chronic resolved and 6 HBV-free healthy controls (HCs). Flow cytometry and histological assays were applied in a second HBV cohort for validation. RESULTS: Both IA and AR were characterised by high levels of intrahepatic exhausted CD8+ T (Tex) cells. In IA, Tex cells were mainly derived from liver-resident GZMK+ effector memory T cells and self-expansion. By contrast, peripheral CX3CR1+ effector T cells and GZMK+ effector memory T cells were the main source of Tex cells in AR. In IA but not AR, significant cell-cell interactions were observed between Tex cells and regulatory CD4+ T cells, as well as between Tex and FCGR3A+ macrophages. Such interactions were potentially mediated through human leukocyte antigen class I molecules together with their receptors CANX and LILRBs, respectively, contributing to the dysfunction of antiviral immune responses. By contrast, CX3CR1+GNLY+ central memory CD8+ T cells were concurrently expanded in both liver and blood of AR, providing a potential surrogate marker for viral resolution. In clinic, intrahepatic Tex cells were positively correlated with serum alanine aminotransferase levels and histological grading scores. CONCLUSION: Our study dissects the coordinated immune responses for different HBV infection phases and provides a rich resource for fully understanding immunopathogenesis and developing effective therapeutic strategies.

Effect of EGFR-TKI targeted therapy in patients with advanced non-small cell lung cancer.

OBJECTIVE: To investigate the effect of EGFR-TKI targeted therapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS: Eighty-four cases of NSCLC were retrospectively assigned into an observation group (OG, n=42) and a control group (CG, n=42) according to the treatment methods. The CG received conventional chemotherapy, and the OG received icotinib hydrochloride EGFR-TKI targeted therapy. The clinical efficacy, cellular immunity, humoral immunity, quality of life, adverse reactions and survival time were compared between the two groups. Cox regression analysis was used to analyze the factors influencing the prognosis of advanced NSCLC. RESULTS: The total response rate was substantially higher, and the incidence of adverse reactions was considerably lower in the OG than those in the CG (all P<0.05). The post-treatment SF-36 score was increased in both groups with significantly higher score in the OG than the CG (all P<0.001). The post-treatment CD4+ counts in both groups were notably lower than those of pre-treatment, and the count was lower in the CG than that in the OG (all P<0.001). The post-treatment CD8+ counts in both groups were notably higher after treatment than those of pre-treatment and was higher in the CG than that in the OG (all P<0.001). The post-treatment levels of IgM and IgA in both groups were declined compared with those of pre-treatment (P<0.001) with significantly lower levels in the OG than the CG (P<0.01). The 18-month mortality of the OG was significantly lower than that of the CG (P<0.05). Cox regression analysis showed that lesion diameter and differentiation degree of tumor cells were independent factors influencing the prognosis (P<0.05). CONCLUSION: EGFR-TKI targeted therapy can relieve clinical symptoms, and improve immune function and quality of life of patients with advanced NSCLC, which is worthy of clinical application.

Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p.

BACKGROUND: Increased proliferation and impaired death of fibroblast-like synovial cells play an important role in the development of rheumatoid arthritis (RA). Survivin plays an important role in the prodromal stage and prognosis of RA and has been introduced as a biomarker of joint injury in RA patients. The purpose of this study was to explore whether propionate alleviates RA through miR-140-5p/survivin pathway. METHODS: The synovial tissues of RA patients were collected to detect the expression levels of miR-140-5p and survivin; normal human fibroblast-like synovial cells (HLSs) and RA fibroblast-like synovial cells (RA-FLSs) were cultured and treated with 10 mM of sodium propionate (SP), then the expressions of miR-140-5p and survivin, cell viability and apoptosis were detected; collagen induced arthritis (CIA) rat model was constructed and treated with SP, then the tissue inflammation level and the expression levels of miR-140-5p and Survivin were detected. RESULTS: The expression of miR-140-5p decreased in synovial tissues of RA patients and RA-FLSs cells, while the expression of survivin increased significantly in RA patients. SP promoted miR-140-5p expression and apoptosis in RA-FLSs cells and inhibited survivin expression and cell viability of RA-FLSs cells. In addition, miR-140-5p plays a protective role by targeting survivin. Importantly, in the CIA rat model, SP reduced joint inflammatory response, and the miR-140-5p inhibitor weakened the protective effect of SP. CONCLUSION: SP can alleviate RA by promoting the expression of miR-140-5p and inhibiting the excessive proliferation and death impairment of RA-FLSs cells induced by survivin.

Nanocomposites of immobilized nano-zirconia on low-cost activated carbon derived from hazelnut shell for enhanced removal of 3-Nitro-4-Hydroxy-Phenylarsonic acid from water.

3-Nitro-4-hydroxy-phenylarsonic acid (NHPA) as a veterinary drug can degraded into highly toxic inorganic arsenic and will be harmful to environment and food safety. Nanocomposites for the uptake of NHPA were obtained by efficiently immobilizing the nano-sized zirconium oxide onto hazelnut shell-based activated carbon using pyrolysis method. We found that the pyrolysis temperature played a crucial role in the adsorptive performances of the nanocomposites. The prepared nanocomposite at pyrolysis temperature of 600 °C with a mass ratio of ZrOCl2/activated carbon of 1:3 exhibited a fast adsorption equilibrium for NHPA within 5 min, excellent adsorption capacity of 825.7 mg g-1 and the higher adsorption capacity with the increase in temperature from 20 to 45 °C across a pH range of 4-6. 90% of the NHPA uptake was sustained in the NaNO3 solution of 0.7 mol L-1. The adsorption data were well simulated by the Langmuir and pseudo-second order equations. Thermodynamic parameters suggested that the uptake of the NHPA occurred spontaneously (ΔG0<0) with an endothermic characteristic (ΔH0>0). A synergetic effect of electrostatic attraction, As-O-Zr surface coordination and π-π interaction is the main adsorption mechanism of the nanocomposites for the removal of the NHPA.

Comparison of prognosis predictive value of 4 disease severity scoring systems in patients with acute respiratory failure in intensive care unit: A STROBE report.

ABSTRACT: Various disease severity scoring systems were currently used in critically ill patients with acute respiratory failure, while their performances were not well investigated.The study aimed to investigate the difference in prognosis predictive value of 4 different disease severity scoring systems in patients with acute respiratory failure.With a retrospective cohort study design, adult patients admitted to intensive care unit (ICU) with acute respiratory failure were screened and relevant data were extracted from an open-access American intensive care database to calculate the following disease severity scores on ICU admission: acute physiology score (APS) III, Sequential Organ Failure Assessment score (SOFA), quick SOFA (qSOFA), and Oxford Acute Severity of Illness Score (OASIS). Hospital mortality was chosen as the primary outcome. Multivariable logistic regression analyses were performed to analyze the association of each scoring system with the outcome. Receiver operating characteristic curve analyses were conducted to evaluate the prognosis predictive performance of each scoring system.A total of 4828 patients with acute respiratory failure were enrolled with a hospital mortality rate of 16.78%. APS III (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.02-1.03), SOFA (OR 1.15, 95% CI 1.12-1.18), qSOFA (OR 1.26, 95% CI 1.11-1.42), and OASIS (OR 1.06, 95% CI 1.05-1.08) were all significantly associated with hospital mortality after adjustment for age and comorbidities. Receiver operating characteristic analyses showed that APS III had the highest area under the curve (AUC) (0.703, 95% CI 0.683-0.722), and SOFA and OASIS shared similar predictive performance (area under the curve 0.653 [95% CI 0.631-0.675] and 0.664 [95% CI 0.644-0.685], respectively), while qSOFA had the worst predictive performance for predicting hospital mortality (0.553, 95% CI 0.535-0.572).These results suggested the prognosis predictive value varied among the 4 different disease severity scores for patients admitted to ICU with acute respiratory failure.

Layer-by-Layer Assembly of Polystyrene/Ag for a Highly Reproducible SERS Substrate and Its Use for the Detection of Food Contaminants.

Polystyrene (PS) spheres were prepared through an emulsifier-free emulsion polymerization method, in which the reaction time, ionic strength, concentrations of copolymer were studied in detail. The resulting PS microspheres and Ag nanoparticles were used to construct a surface enhanced Raman scattering (SERS) substrate by a layer-by-layer assembly method. A relatively uniform distribution of PS/Ag in the films was obtained, and the multilayer substrate presented excellent SERS reproducibility and a tunable enhancement effect. The SERS substrate was used for detecting harmful pesticides (malachite green and dimetridazole) in food samples, with a limit of detection as low as 3.5 ppb. The obtained plasmonic composite has a promising future in the field of SERS sensing.

Non-Intrusive Load Monitoring for Residential Appliances with Ultra-Sparse Sample and Real-Time Computation.

To achieve the goal of carbon neutrality, the demand for energy saving by the residential sector has witnessed a soaring increase. As a promising paradigm to monitor and manage residential loads, the existing studies on non-intrusive load monitoring (NILM) either lack the scalability of real-world cases or pay unaffordable attention to identification accuracy. This paper proposes a high accuracy, ultra-sparse sample, and real-time computation based NILM method for residential appliances. The method includes three steps: event detection, feature extraction and load identification. A wavelet decomposition based standard deviation multiple (WDSDM) is first proposed to empower event detection of appliances with complex starting processes. The results indicate a false detection rate of only one out of sixteen samples and a time consumption of only 0.77 s. In addition, an essential feature for NILM is introduced, namely the overshoot multiple (which facilitates an average identification improvement from 82.1% to 100% for similar appliances). Moreover, the combination of modified weighted K-nearest neighbors (KNN) and overshoot multiples achieves 100% appliance identification accuracy under a sampling frequency of 6.25 kHz with only one training sample. The proposed method sheds light on highly efficient, user friendly, scalable, and real-world implementable energy management systems in the expectable future.

Nanocomposites of graphene and zirconia for adsorption of organic-arsenic drugs: Performances comparison and analysis of adsorption behavior.

3-Nitro-4-hydroxy-phenylarsonic acid (3-NHPAA), an organic-arsenic compound, as one of widely used antibacterial veterinary drug, has greatly attracted the attention due to its potential threats on ecological environment. A series of the nanocomposites of zirconia nanoparticles with crystal phases (pure monoclinic, pure tetragonal and mixed phase (monoclinic + tetragonal)) anchored on reduced graphene oxide were produced through managing the concentration of triethanolamine solution and the reaction time. The effects of the crystal phases of the zirconia in the structure of the nanocomposites were played a key role in the adsorption performances of the 3-NHPAA. Experiment data identified the nanocomposites with monoclinic phase of zirconia excelled at the adsorption of the 3-NHPAA with a higher adsorption capacity up to 207.2 mg g-1. The uptake of the 3-NHPAA by the three nanocomposites was implemented within 60 min and highly pH-dependent which illustrated electrostatic attraction between them as a main mechanism during the adsorption process. A wider pH range (3.8-8.8) for the uptake of the 3-NHPAA by the nanocomposites with the monoclinic phase of zirconia was obtained compared with the nanocomposites containing tetragonal phase (3.8-5.9) or the mixed phase (3.8-7.1) of zirconia. The adsorption of the 3-NHPAA was well described by the pseudo-second order kinetic and Langmuir equations. The thermodynamic parameters suggested that the adsorption of the 3-NHPAA over the three nanocomposites was endothermic and spontaneous in nature. In summary, the nanocomposites of reduced graphene oxide and monoclinic phase of zirconia nanoparticles as an adsorbent were better to the adsorption of the 3-NHPAA.

Synthesis, characterization, and photoelectric properties of iridium(iii) complexes containing an N hetero-dibenzofuran C

In this study, three high-efficient green light iridium(iii) complexes were designed and synthesized, wherein 2-methyl-8-(2-pyridine) benzofuran [2,3-B] pyridine (MPBFP) is the main ligand and three ß-diketone derivatives, namely 3,7-diethyl-4,6-nondiazone (detd), 2,2,6,6-tetramethyl-3,5-heptyldione (tmd) and acetylacetone (acac), are ancillary ligands. The thermal stabilities, electrochemical properties, and electroluminescence (EL) performance of these three complexes, namely (MPBFP)2 Ir(detd), (MPBFP)2Ir(tmd) and (MPBFP)2Ir(acac), were investigated. The results show that the absorption peaks of the three complexes range from 260 to 340 nm, and the maximum emission wavelengths are 537 nm, 544 nm and 540 nm, respectively. The LUMO level is -2.18 eV, -2.20 eV, -2.21 eV, and the HOMO level is -5.30 eV, -5.25 eV, and -5.25 eV, respectively. The thermal decomposition temperatures of each of the three compounds are 359 °C, 389 °C and 410 °C respectively, with a weight loss of 5%. Green phosphorescent electroluminescent devices were prepared with the structure of ITO/HAT-CN/TAPC/TCTA/TCTA:X/Bepp2/LiF/Al, and the three complexes were dispersed in the organic light-emitting layer as the guest material X. The maximum external quantum efficiency of the devices is 17.2%, 16.7%, and 16.5%, respectively. The maximum brightness is 57 328 cd m-2, 69 267 cd m-2 and 69 267 cd m-2, respectively. With respect to the EL properties, (MPBFP)2Ir(detd) is the best performer among the three complexes. The different performances exhibited by these complexes were discussed from the view point of substituent effect on the ß-diketone ligands.

The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis.

BACKGROUND: Several randomized controlled trials (RCTs) have compared the treatment of acute lung injury (ALI) with omega-3 fatty, yet the results remained inconsistent. Therefore, we attempted this meta-analysis to analyze the role of omega-3 fatty in the treatment of ALI patients. METHODS: We searched PubMed databases from inception date to October 31, 2019, for RCTs that compared the treatment of ALI with or without omega-3 fatty. Two authors independently screened the studies and extracted data from the published articles. Summary mean differences (MD) with 95% confidence intervals (CI) were calculated for each outcome by fixed- or random-effects model. RESULTS: Six RCTs with a total of 277 patients were identified, of whom 142 patients with omega-3 fatty acid treatment and 135 patients without omega-3 fatty treatment. Omega-3 fatty treatments significantly improve the PaO2 (MD = 13.82, 95% CI 8.55-19.09), PaO2/FiO2 (MD = 33.47, 95% CI 24.22-42.72), total protein (MD = 2.02, 95% CI 0.43-3.62) in ALI patients, and omega-3 fatty acid treatments reduced the duration of mechanical ventilation (MD = - 1.72, 95% CI - 2.84 to - 0.60) and intensive care unit stay (MD = - 1.29, 95% CI - 2.14 to - 0.43) in ALI patients. CONCLUSIONS: Omega-3 fatty can effectively improve the respiratory function and promote the recovery of ALI patients. Future studies focused on the long-term efficacy and safety of omega-3 fatty use for ALI are needed.

In situ sampling of tetracycline antibiotics in culture wastewater using diffusive gradients in thin films equipped with graphene nanoplatelets.

A device of graphene nanoplatelet-based diffusion gradients in thin-films (G-DGT) was developed for in situ sampling of tetracycline (TC), oxytetracycline (OTC) and chlortetracycline (CTC) in aquatic environment. The accumulation of antibiotics in a synthetic solution by the proposed G-DGT was consistent with the theoretical curves predicted by the DGT equation. The values of the detection and quantification limits of G-DGT using high-performance liquid chromatography over the deployment time of 7 days were at the level of µg L-1 for the three antibiotics. The performance of the proposed G-DGT was unaffected by pH (3-9) and ionic strength (0.001-0.7 mol L-1 NaNO3). Fulvic acid did not significantly interfere with the performance of the proposed G-DGT device when the mass ratios between the three antibiotics and fulvic acid were within the range of 1:10-1:100. Humic acid had a significant effect on the performance of the proposed G-DGT for the sampling of the three antibiotics due to strong complexation and coprecipitation between the antibiotics and humic acid. The proposed G-DGT was used for the in situ sampling in spiked freshwaters and livestock culture wastewater and exhibited good precision and accuracy without notable interference from the matrices.

In-situ monitoring of phenol in surface waters by diffusive gradients in thin films technique based on the nanocomposites of zero-valent iron@biochar.

The nano-sized zero valent iron assisted biochar from hazelnut shell (nZVI@biochar) was prepared and assessed for the feasibility as the binding agent in diffusive gradients in thin-films (DGT) technique. The 1.5% agarose solution containing the optimal nZVI@biochar dose of 15 g L-1 was used to prepare the nZVI@biochar binding gel which owned a high capacity (1010 ± 50 µg disc-1) and a rapid uptake within 30 min. The elution efficiency of phenol from the loaded binding gel was up to 99.3% using the mixture of 1% hydroxylamine hydrochloride and 0.05 mol L-1 HCl. The phenol uptake of nZVI@biochar-DGT increased linearly with the increase of deployment time (R2 = 0.9938) and was in accord with the theoretical values from DGT equation, while there was no notable interference of the sample matrixes on the phenol uptake of nZVI@biochar-DGT in the spiked freshwaters. The good performance of nZVI@biochar-DGT was found under a range of pH (4.1-10.2), ionic strength (as pNaNO3) (0.155-4), and dissolved organic matter up to 20 mg L-1. In field, the monitoring of nZVI@biochar-DGT was more representative than the results from the grab-sampling with better precision and lower sampling frequency, which can provide reliable information, reduce the cost of human resources, and improve efficiency. These illustrate that the nZVI@biochar is more suitable as the binding agent of DGT for uptake of phenol and nZVI@biochar-DGT is an effective tool to monitor in-situ phenol in waters.

Nanocomposites of zero-valent Iron@Activated carbon derived from corn stalk for adsorptive removal of tetracycline antibiotics.

The hybrid nanocomposites of zero-valent iron loaded the activated carbon derived from the corn stalk (ZVI@ACCS) was prepared and used to remove the antibiotics of tetracycline (TC), oxytetracycline (OTC) and chlortetracycline (CTC) from aqueous solution. The adsorption amounts of three antibiotics (103.1 mg g-1 for CTC, 72.9 mg g-1 for OTC and 81.5 mg g-1 for TC) were sensitive to the temperature and independent of pH in the range of 4.2-7.1 at 298 K through the synergistic interactions of the electrostatic attraction, the bridging complexation and the surface complexation. The equilibrium was performed within 20 min at 298 K. The spontaneous (ΔGo<0) and endothermic (ΔHo>0) adsorption of three antibiotics onto the ZVI@ACCS nanocomposites gave a better matching (r2 > 0.99) with Langmuir and pseudo-second-order models.