Influence of bronchopulmonary dysplasia on cerebral blood flow in preterm infants: a prospective study based on arterial spin labeling / 中国当代儿科杂志

OBJECTIVES@#To investigate local cerebral blood perfusion in preterm infants with bronchopulmonary dysplasia (BPD) based on cerebral blood flow (CBF) values of arterial spin labeling (ASL).@*METHODS@#A prospective study was conducted on 90 preterm infants with a gestational age of <32 weeks and a birth weight of <1 500 g who were born in the Department of Obstetrics and admitted to the Department of Neonatology in the Third Affiliated Hospital of Zhengzhou University from August 2021 to June 2022. All of the infants underwent cranial MRI and ASL at the corrected gestational age of 35-40 weeks. According to the presence or absence of BPD, they were divided into a BPD group with 45 infants and a non-BPD group with 45 infants. The two groups were compared in terms of the CBF values of the same regions of interest (frontal lobe, temporal lobe, parietal lobe, occipital lobe, thalamus, and basal ganglia) on ASL image.@*RESULTS@#Compared with the non-BPD group, the BPD group had a significantly lower 1-minute Apgar score, a significantly longer duration of assisted ventilation, and a significantly higher incidence rate of fetal distress (P<0.05). After control for the confounding factors such as corrected age and age at the time of cranial MRI by multiple linear regression analysis, compared with the non-BPD group, the BPD group still had higher CBF values of the frontal lobe, temporal lobe, parietal lobe, occipital lobe, basal ganglia, and thalamus at both sides (P<0.05).@*CONCLUSIONS@#BPD can increase cerebral blood perfusion in preterm infants, which might be associated with hypoxia and a long duration of assisted ventilation in the early stage.

Construction of early risk prediction models for bronchopulmonary dysplasia in preterm infants / 中国当代儿科杂志

OBJECTIVES@#To construct risk prediction models for bronchopulmonary dysplasia (BPD) in preterm infants on postnatal days 3, 7, and 14.@*METHODS@#A retrospective analysis was performed on the medical data of 414 preterm infants, with a gestational age of <32 weeks and a birth weight (BW) of <1 500 g, who were admitted to the neonatal intensive care unit from July 2019 to April 2021. According to the diagnostic criteria for BPD revised in 2018, they were divided into a BPD group with 98 infants and a non-BPD group with 316 infants. The two groups were compared in terms of general status, laboratory examination results, treatment, and complications. The logistic regression model was used to identify the variables associated with BPD. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of models.@*RESULTS@#The logistic regression analysis showed that BW, asphyxia, grade III-IV respiratory distress syndrome (RDS), acute chorioamnionitis, interstitial pneumonia, fraction of inspired oxygen (FiO@*CONCLUSIONS@#BW, asphyxia, grade III-IV RDS, acute chorioamnionitis, interstitial pneumonia, FiO

N-Phenyl-morpholine-4-carboxamide.

In the title compound, C(11)H(14)N(2)O(2), the urea-type NC=ON moiety [planar to within 0.0002 (13) Å] is inclined to the phenyl ring by 42.88 (8) Å, and the morpholine ring has a chair conformation. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into infinite chains in [001].

Ethyl 2-amino-6-benzyl-4,5,6,7-tetra-hydro-thieno[2,3-c]pyridine-3-carboxyl-ate.

In the title compound, C(17)H(20)N(2)O(2)S, the tetra-hydro-pyridine ring adopts an envelope conformation with the N atom at the flap position; the phenyl ring makes a dihedral angle of 81.06 (10)° with the thio-phene ring. The amino group links with the carbonyl O atom via intra-molecular N-H⋯O hydrogen bonding, forming a six-membered ring. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into infinite chains running along the b axis.

3-Phenyl-2-(pyrrolidin-1-yl)-5,6-dihydro-8H-thio-pyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one.

In the title compound, C(19)H(19)N(3)OS(2), the thio-pyran ring adopts a twist-chair conformation and the pyrimidinone unit is essentially planar, with a mean deviation of 0.0497 Å. The thio-phene ring is essentially planar with a maximum deviation of 0.024 (2) Å, while the pyrrolidine ring exhibits an envelope conformation. The pyrimidinone and thio-phene rings are almost coplanar, forming a dihedral angle of 6.31 (15)°, while the dihedral angle between the mean planes of the phenyl ring and the pyrimidinone ring is 68.13 (10)°. In the crystal structure, adjacent mol-ecules are linked by C-H⋯O hydrogen bonds, forming a two-dimensional network in the ac plane.

Bis(acetyl-acetonato-κO,O')(methanol-κO)(thio-cyanato-κN)manganese(III).

In the title complex, [Mn(C(5)H(7)O(2))(2)(NCS)(CH(4)O)], the Mn(III) atom has a slightly distorted octa-hedral coordination formed by five O atoms and one N atom. The equatorial positions are occupied by four O atoms of two acetyl-acetonate ligands, while the axial positions are occupied by the N atom of the thio-cyanate anion and the O atom of the methanol mol-ecule. In the crystal structure, complex mol-ecules are linked by an inter-molecular O-H⋯S hydrogen bond, forming a chain running along [101].

catena-Poly[[(1,12,15,26-tetra-aza-5,8,19,22-tetra-oxa-3,4:9,10:17,18:23,24-tetra-benzocyclo-octa-cosane-κN,N,N,N)nickel(II)]-µ-terephthalato-κO:O].

In the title compound, [Ni(C(8)H(4)O(4))(C(36)H(44)N(4)O(4))](n), the Ni(II) atom is coordinated in a distorted octa-hedral geometry by the four N atoms of the 1,12,15,26-tetra-aza-5,8,19,22-tetra-oxa-3,4:9,10:17,18:23,24-tetra-benzocyclo-octa-cosane ligand and two O atoms from the terephthalate dianions. The Ni(II) atoms, which lie on inversion centres, are linked via terephthalate ligands to form a chain structure along [101]. The structure is stabilized by three intra-molecular and one inter-molecular N-H⋯O hydrogen bonds.

(E)-N'-(Furan-2-ylmethyl-ene)-4-(quinolin-8-yl-oxy)butanohydrazide.

In the title mol-ecule, C(18)H(17)N(3)O(3), the dihedral angle between the mean planes of the furan ring and the quinoline group is 77.4 (2)°. In the crystal structure, inter-molecular N-H⋯N hydrogen bonds link the mol-ecules into centrosymmetric dimers.

3-Phenyl-2-(piperidin-1-yl)-3,5,6,8-tetra-hydro-4H-thio-pyrano[3',4':2,3]thieno[5,4-d]pyrimidin-4-one.

In the title compound, C(20)H(21)N(3)OS(2), the piperidinyl ring has a distorted chair conformation. Weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into centrosymmetric dimers. The crystal packing exhibits short inter-molecular S⋯S distances of 3.590 (2) Å.