[Effect of carbostimulin on reparative osteogenesis in rabbits of different ages]. / O vliianii karbostimulina na reparativnyi osteogenez u krolikov razlichnogo vozrasta.

Rate of reparative osteogenesis was studied after partial resection of rabbit radius bone. Within 15 days of the restoration period the content of dry residue was increased by 26%, 17% and 35% in regenerate of 2-months old animals, treated with their mixtures as compared with 6-months old rabbits. Content of calcium was increased 1.5-fold in callus of all the 2-months old animals as compared with that in the 6-months old rabbits.

[Effect of carbostimulin and its mixture with vitamin D3 on the mineralization process of the bone callus in rabbits]. / Vliianie karbostimulina i smesi ego s vitaminom D3 na protsess mineralizatsii kostnoi mozoli krolikov.

Mineralization of rabbit bone callus was studied within 15 days after resection of the upper part of radius bone inder conditions of treatment with carbostimuline and its mixture with vitamin D3. Content of calcium in the bone regenerate was increased by 40.8% after administration of carbostimuline and--by 70.5% after treatment with mixture containing vitamin D3. These preparations caused only slight effects on the phosphorus content. Dry residue in the regenerate os f animals, treated with the preparations, was increased approximately 2-fold (43% and 23%, respectively, p less than or equal to 0.001) as compared with control group. Content of citric acid was distinctly higher in the bone tissue of the treated animals. Within 15 days after the operation content of sialic acids wanormalized in blood serum of the animals. The data obtained were corroborated by X-ray and histologic examinations.