1.
J Org Chem
; 65(25): 8704-8, 2000 Dec 15.
Article
in English
| MEDLINE
| ID: mdl-11112592
ABSTRACT
Addition of Et(2)AlCN and i-PrOH to ketosulfinimines (N-sulfinyl imines) affords corresponding alpha-alkyl alpha-amino nitriles in moderate to good yields. The diastereoselectivity is largely dependent on the E/Z isomer ratio of the ketosulfinimine. Hydrolysis of the diastereomerically pure amino nitriles affords enantiopure alpha-alkyl alpha-amino acids in moderate to good yields.
Subject(s)
Amino Acids/chemical synthesis , Sulfonium Compounds/chemistry , Imines/chemistry , Magnetic Resonance Spectroscopy
2.
J Org Chem
; 65(22): 7663-6, 2000 Nov 03.
Article
in English
| MEDLINE
| ID: mdl-11076632