ABSTRACT
Soft tissue perineuriomas are an unusual type of peripheral nerve sheath tumors distinct from schwannomas and neurofibromas, with interesting histologic findings. They are not well characterized on radiographic examination. We report this case of a patient with sinonasal perineurioma to help define the imaging and pathologic features of this rare head and neck tumor.
Subject(s)
Nerve Sheath Neoplasms/pathology , Paranasal Sinus Neoplasms/pathology , Paranasal Sinuses/pathology , Biopsy , Chromosomes, Human, Pair 22 , Endoscopy , Female , Humans , In Situ Hybridization, Fluorescence , Middle Aged , Nerve Sheath Neoplasms/diagnostic imaging , Nerve Sheath Neoplasms/surgery , Paranasal Sinus Neoplasms/diagnostic imaging , Paranasal Sinus Neoplasms/surgery , Paranasal Sinuses/diagnostic imaging , Soft Tissue Neoplasms/diagnostic imaging , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/surgery , Tomography, X-Ray ComputedABSTRACT
Bioassay guided fractionation of Boenninghausenia sessilicarpa (Rutaceae) resulted in the isolation of a new dimeric coumarin glucoside 9'-methoxyl rutarensin (1) and a cytotoxic compound rutamarin (4), as well as an antivirus component leptodactylone (8), together with six known coumarins. Their structures were elucidated by 1D- and 2D NMR spectroscopy and ESI-MS analyses, respectively. Rutamarin (4) showed significant inhibitory activities against A-549, Bel-7402, HepG-2 and HCT-8 tumour cell lines with IC50s of 1.318, 2.082, 2.306 and 2.497 microg/ml. In addition, leptodactylone (8) showed potent protective activity on cells infected by SARS-CoV with ratio of 60% at 100 microg/ml.
Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Antiviral Agents/isolation & purification , Coumarins/isolation & purification , Drugs, Chinese Herbal/pharmacology , Rutaceae/chemistry , Animals , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/isolation & purification , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Benzopyrans/chemistry , Benzopyrans/isolation & purification , Benzopyrans/pharmacology , Cell Line, Tumor , Cell Proliferation/drug effects , Chlorocebus aethiops , Coumarins/chemistry , Coumarins/pharmacology , Drugs, Chinese Herbal/chemistry , Humans , KB Cells , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Severe acute respiratory syndrome-related coronavirus/drug effects , Severe acute respiratory syndrome-related coronavirus/growth & development , Spectrometry, Mass, Electrospray Ionization , Spectrophotometry, Infrared , Vero CellsABSTRACT
Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward "normal" and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.
Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Paclitaxel/analogs & derivatives , Paclitaxel/pharmacology , Animals , Antineoplastic Agents, Phytogenic/chemistry , Drug Resistance, Multiple , Drug Resistance, Neoplasm , Humans , Paclitaxel/chemistry , Structure-Activity Relationship , Tubulin/metabolismABSTRACT
Concentrations of paclitaxel and its congeners 10-deacetylpaclitaxel, cephalomannine, 10-deacetylcephalomannine, baccatin III and 10-deacetylbaccatin III in Taxus mairei were determined by HPLC. It was found that paclitaxel is abundant in roots and stem bark. The concentrations of paclitaxel and its congeners in the plants growing in one area may vary to a great extent from those growing in another area.
Subject(s)
Antineoplastic Agents, Phytogenic/pharmacokinetics , Paclitaxel/pharmacokinetics , Phytotherapy , Taxus/metabolism , Chromatography, High Pressure Liquid , Humans , Paclitaxel/analogs & derivatives , Plant Extracts/pharmacokinetics , Plant StructuresABSTRACT
Cytochalasin D which shows marked cytotoxic effects on multi-tumor cells was newly isolated at high content(5.28 mg/g, dry weight) from Fungus Hypocrella bambusae(B.et Br.) Sacc. Its structure was elucidated by spectroscopic methods. Two-dimensional NMR techniques were applied to make complete assignment for the 1H- and 13C-NMR chemical shifts of this compound.
Subject(s)
Ascomycota/chemistry , Cytochalasin D/isolation & purification , Animals , China , Cytochalasin D/chemistry , Magnetic Resonance Spectroscopy , Molecular Structure , Nucleic Acid Synthesis Inhibitors/chemistry , Nucleic Acid Synthesis Inhibitors/isolation & purificationABSTRACT
A new bicyclic taxoid, 5-deacetyltaxachitriene B (2) together with a known bicyclic taxoid (1) were isolated from needles of Taxus chinensis. Spectral characteristics for these bicyclic taxoids were discussed.
