ABSTRACT
Les effets pharmacologiques de la 4-phenyl-1;5-benzodiazepin-2-one ont ete examines chez des souris par des tests comportementaux classiques (Test de planche a trous; Test de labyrinthe et Test de la tige tournante) et compares par rapport aux produits dont le potentiel anxiogenique ou anxiolytique sont connus. L'analyse de nos resultats a montre que la 4-phenyl-1;5-benzodiazepin-2-one et le diazepam ont augmente le temps passe dans les bras ouverts; tandis que la picrotoxin a entraine la diminution de ce temps. Considerant les resultats de l'evaluation de l'activite locomotrice; du comportement exploratoire et du comportement des animaux sur la tige tournante; le diazepam et la 4-phenyl-1;5-benzodiazepin-2-one ont influence de facon significative ces derniers par rapport a la picrotoxin et au vehicule. Ces donnees suggerent que la 4-phenyl-1;5- benzodiazepin-2-one possede une activite anxiolytique
Subject(s)
Anti-Anxiety Agents/pharmacology , BenzodiazepinesABSTRACT
The acute LD50s of ferulenol were determined in albino mice by single po or ip as 2,100 and 319 mg/kg bw, respectively. Ferulenol had a higher LD50 compared to warfarin and thus has a lower acute toxicity. Three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages similar to those described in ferulosys and anti-vitamin K experimental poisonings. Male mice were more sensitive to intoxication by ferulenol than were females.
Subject(s)
Coumarins/toxicity , Administration, Oral , Animals , Coumarins/administration & dosage , Dose-Response Relationship, Drug , Female , Injections, Intraperitoneal , Lethal Dose 50 , Male , MiceABSTRACT
The acute toxicity of the fessoukh extract (FE) was studied in rats and mice. In single oral dose administration mode, FE has moderate toxicity; the LD50s were 1650 mg/kg bw in rats and 2000 mg/kg bw in mice. In albino rats, with baits containing 0.01 to 10% FE, 0.01% produced 100% mortality in 15 d; with 0.1%, all rats died in 9 d. Baits containing 0.1% were toxic, more consumed, required less product and did not cause apprehension in the rats. A trial conducted with wild rats (Rattus norvegicus) using 0.1% FE baits demonstrated fessoukh's rodenticide effects.
