ABSTRACT
Mechanistic Monte Carlo simulations calculating DNA damage caused by ionizing radiation are highly dependent on the simulation parameters. In the present study, using the Geant4-DNA toolkit, the impact of different parameters on DNA damage induced in a bacterial cell by X- and gamma-ray irradiation was investigated. Three geometry configurations, including the simple (without DNA details), the random (a random multiplication of identical DNA segments), and the fractal (a regular replication of DNA segments using fractal Hilbert curves), were simulated. Also, three physics constructors implemented in Geant4-DNA, i.e., G4EmDNAPhysics_option2, G4EmDNAPhysics_option4, and G4EmDNAPhysics_option6, with two energy thresholds of 17.5 eV and 5-37.5 eV were compared for direct DNA damage calculations. Finally, a previously developed mathematical model of cell repair called MEDRAS (Mechanistic DNA Repair and Survival) was employed to compare the impact of physics constructors on the cell survival curve. The simple geometry leads to undesirable results compared to the random and fractal ones, highlighting the importance of simulating complex DNA structures in mechanistic simulation studies. Under the same conditions, the DNA damage calculated in the fractal geometry was more consistent with the experimental data. All physics constructors can be used alternatively with the fractal geometry, provided that an energy threshold of 17.5 eV is considered for recording direct DNA damage. All physics constructors represent a similar behavior in generating cell survival curves, although the slopes of the curves are different. Since the inverse of the slope of a bacterial cell survival curve (i.e., the D10-value) is highly sensitive to the simulation parameters, it is not logical to determine an optimal set of parameters for calculating the D10-value by Monte Carlo simulation.
ABSTRACT
Thermoluminescence dosimetry is considered as an effective method in estimating the absorbed doses to organs in different imaging modalities. The present study focuses on dosimetry in dual-energy X-ray absorptiometry scans, for patients, and phantoms in various imaging centres. The cubical LiF (Mg, Ti) thermoluminescence dosemeters were inserted inside the holes of the Rando phantom slabs, to measure the absorbed dose to different organs in the whole body and lumbar scans. According to the results the maximum entrance skin dose was found to be 202.06 µGy for Hologic discovery W, which uses the fan beam scanning mode. The Norland XR-800 device took the scans with a much lower dose, as it uses the pencil beam for scanning the patients. The results of the study show that the radiation beam type, patient thickness, imaging technique and scan time may affect the radiation dose received by patient.
