ABSTRACT
Epidemiology for diverticular disease of the colon is rather difficult to assess because of the almost regularly selection of the patients submitted to analysis and described in literature. Therefore data extracted from different experiences are useful only for orientative epidemiologic implications. In the meanwhile these studies have been very useful to understand the possible reasons of its insurgence and evolution. Actually for etiopathogenesis the more diffuse opinion is to give importance to low fibre diet and to intrinsic motor derangement of the colon.
Subject(s)
Diverticulum, Colon/epidemiology , Diverticulum, Colon/etiology , Diverticulum, Colon/pathology , Diverticulum, Colon/physiopathology , Global Health , Humans , IncidenceABSTRACT
The interest in developing a prosthesis that may be effective in nerve repair as an alternative to autologous grafts, promotes experimental investigations in order to improve the so called tubulization techniques. A review of the literature of the last 10 years is performed to draw an outline of the state of the research, pointing out three main topics: the animal model, the type of the conduit and the length of the repaired gap. The rat, the rabbit and non human primates are the species with which experimental models are most often fashioned for this purpose. Among the great number of investigated conduits, interesting perspectives are arrived at mainly by those obtained with biologic or degradable materials; until now, experimental nerve defects of 3 cm or less are better repaired with artificial guides while unsatisfactory results were reported for the repair of longer gaps. The introduction in the micro-environment of the conduit of neurotrophic substances represents a challenge for the future development of these investigations aimed at improving healing and obtaining nerve regeneration through extensive defects.
