ABSTRACT
OBJECTIVE: Two cases of metanephric adenoma are presented, a rare benign renal tumor, and a literature review is done under the current WHO classification (2016). METHODS: Standard histopathological study was performed with hematoxylin-eosin and immunohistochemistry to analyze the expression of WT, Vimentin, Racemase, CK7, CD10 and RCC. RESULTS: Neoplasms of 3 and 4.5 cm, histologically, exhibiting tubulopapillary architecture. There was no evidence of significant nuclear atypia and mitotic figures. Immunohistochemical study showed positive immunoreaction for WT1 and Vimentin in tumor cells. CONCLUSIONS: Two new cases of metanephric adenoma are presented and a review of the literature was performed in order to discuss the prognosis and differential diagnosis of metanephric adenoma. This is a rare tumor and its diagnosis lies on its morphology and its immunohistochemical profile.
Subject(s)
Adenoma , Kidney Neoplasms , Adenoma/pathology , Adenoma/surgery , Adolescent , Female , Humans , Kidney Neoplasms/pathology , Kidney Neoplasms/surgery , Male , Middle AgedABSTRACT
OBJETIVO: Presentamos 2 casos de adenoma metanéfrico, un tumor renal benigno poco frecuente y realizamos una revisión de la literatura bajo la clasificación actual de la OMS (2016). MÉTODOS: Se realizaron cortes de bloques de parafina para tinción con HE y técnicas inmunohistoquímicas para analizar la expresión de WT, Vimentina, Racemasa, CK7, CD10 y RCC. RESULTADOS: Las neoplasias de 3 y 4,5 cm, histológicamente mostraban arquitectura tubular y papilar. No se evidenció atipia nuclear significativa ni figuras de mitosis. El estudio inmunohistoquímico demostró inmunorreacción positiva de las células tumorales para WT1 y Vimentina. CONCLUSIONES: Presentamos 2 nuevos casos de adenoma metanéfrico y realizamos revisión de la literatura que hay al respecto para discutir la evolución y el diagnóstico diferencial del adenoma metanéfrico. Este es un tumor poco frecuente y su diagnóstico reside en su morfología y perfil inmunohistoquímico
OBJECTIVE: Two cases of metanephric adenoma are presented, a rare benign renal tumor, and a literature review is done under the current WHO classification (2016). METHODS: Standard histopathological study was performed with hematoxylin-eosin and immunohistochemistry to analyze the expression of WT, Vimentin, Racemase, CK7, CD10 and RCC. RESULTS: Neoplasms of 3 and 4.5 cm, histologically, exhibiting tubulopapillary architecture. There was no evidence of significant nuclear atypia and mitotic figures. Immunohistochemical study showed positive immunoreaction for WT1 and Vimentin in tumor cells.CONCLUSIONS: Two new cases of metanephric adenoma are presented and a review of the literature was performed in order to discuss the prognosis and differential diagnosis of metanephric adenoma. This is a rare tumor and its diagnosis lies on its morphology and its immunohistochemical profile
