ABSTRACT
Um dos insumos mais utilizados na manufatura de medicamentos homeopáticos é a tintura-mãe. Um método aparentemente útil para o controle de qualidade das tinturas-mães é a análise capilar. Este método analítico, tornado público no início do século passado por Hugo Platz, caiu em desuso após o advento de técnicas cromatográficas mais modernas. Embora empregue técnicas simples e de baixo custo, não há estudos de validação da análise capilar. O presente ensaio teve por objetivo validar o método de análise capilar utilizado no controle de qualidade de tinturas-mãe. Para tanto foram obtidos os espectros capilares das tinturas-mãe de Aconitum napellus L., Strychnos nux vomica L. e Anemone pulsatilla L. provenientes de fornecedores nacionais qualificados pela Associação Brasileira de Farmacêuticos Homeopatas. Os atributos avaliados foram precisão, reprodutibilidade e seletividade. Os resultados alcançados recomendam a utilização do método de análise capilar, conforme proposto por Platz, nas análises qualitativas de tinturas-mãe.
Mother tinctures are one of the most common starting materials used in the elaboration of homeopathic medicines. Capillary analysis seems a useful method for quality control of mother tinctures. This method was publicized in the beginning of the 20th century by Hugo Platz to fell into disuse following the development of the modern chromatographic techniques. Despite the simple techniques involved, and the low cost of the overall method, no studies of validation have yet been performed of Platz´s capillary analysis. The present study sought to validate capillary analysis for quality control of mother tinctures. The capillary spectra of mother tinctures of Aconitum napellus L., Strychos nux vomica L. e Anemone pulsatilla L. provided by Brazilian suppliers certified by the Brazilian Association of Homeopathic Pharmacists were obtained. The attributes evaluated were accuracy, reproducibility and selectivity. The results allow recommending the use of capillary analysis as formulated by Platz for qualitative analysis of mother tinctures.
Subject(s)
Homeopathic Pharmacies , Mother Tincture , Quality Control , Aconitum , Chromatography, Paper , PulsatillaABSTRACT
OBJECTIVE: Studies show that adherence to osteoporosis treatment and prevention is low, which could interfere with therapeutic response. The aim of this study was to evaluate the ability of women to follow a treatment for osteoporosis with different anti-reabsorptives in relation to the prescribed regimen, dose, indications, and mode of ingestion. METHODS: A cross-sectional study that included postmenopausal women all undergoing medicated treatment because of densitometric diagnosis of osteopenia or osteoporosis was carried out by means of the MedTake questionnaire. A total of 227 women at a menopause clinic were studied. The following were evaluated: sociodemographic characteristics, other illnesses, use of concomitant medication, use of medication for osteoporosis, length of use, and ability to follow the treatment in relation to the prescribed regimen, dose, indication, and mode of ingestion. RESULTS: The ability to follow the treatment as evaluated by the MedTake was below 80% for most of the women. No significant difference was found between the daily or weekly bisphosphonate users and those taking raloxifene. The factors associated with inadequate treatment were the following: being 70 years or older (odds ratio [OR], 5.62; 95% CI, 1.23-25.64), being illiterate (OR, 10.14; 95% CI, 2.14-48.12), use of other medications (OR, 0.33; 95% CI, 0.15-0.76), and shorter length of use of medication for osteoporosis (OR, 5.67; 95% CI, 2.27-14.16). CONCLUSION: The ability to follow a treatment involving different anti-reabsorptive medications for osteoporosis is high relative to mode of ingestion, coingestion, and indication and low in relation to knowledge of the correct dose. Low ability is associated with advanced age, being illiterate, not using other medications, and shorter treatment time.
