Overall Survival in Patients With Resected Glioblastoma Treated With Adjuvant Therapy: A Retrospective Study in a Public Hospital in Chile.

Glioblastoma (GB) is the most frequent and aggressive primary tumor of the central nervous system (CNS) in adults. Standard treatment is complete tumor resection followed by concomitant radiochemotherapy (RCT) and subsequent adjuvant temozolomide (TMZ). Information about brain tumors statistics in Latin American countries is scarce, so we aimed to measure the overall survival (OS) of patients with resected GB in a single institution in Chile. This is a retrospective report of 67 patients treated between 2012 and 2019 with resected GB and who received adjuvant treatment with radiotherapy (RT) with and without TMZ during 2012-2019 in this center (Chilean NCI). Most of them were men (72%), ages > 50 years old (57%), with Karnofsky performance status (KPS) scale ≥ 70% (94%) and recursive partitioning analysis-IV (RPA-IV) (60%). Some 54% received concomitant TMZ and RT. Median OS was 11.4 months, with 1-, 2-, and 5-year OS of 48%,15%, and 3% respectively.  In conclusion, in patients with GB treated with RCT at the NCI, OS was the same as expected from international articles. Adjuvant RCT therefore is considered the standard of care at NCI.

A prospective observational safety study on MF59(®) adjuvanted cell culture-derived vaccine, Celtura(®) during the A/H1N1 (2009) influenza pandemic.

BACKGROUND: The present study was a prospective observational study to evaluate the safety profile of Celtura(®), a monovalent, cell culture-derived, inactivated subunit influenza vaccine prepared from A/California/07/2009(H1N1) with the adjuvant MF59(®). Subjects were enrolled prospectively during the H1N1 2009 influenza pandemic at medical centres in Colombia, Chile, Switzerland, and Germany during the period December 2009 to June 2010. METHODS: Subjects ages 18 and older were followed for the occurrence of adverse events (AEs) for six months after vaccination. Adverse events of special interest (AESIs) were neuritis, convulsion (seizure), anaphylaxis, encephalitis, vasculitis, Guillain-Barre syndrome, demyelinating conditions, Bell's palsy, and laboratory-confirmed vaccination failure. RESULTS: Overall, 7348 AEs were reported in 2296 of 3989 enrolled subjects (57.6%). Only two AEs were considered related to injection site reactions. No laboratory-confirmed cases of influenza were reported. There were 108 medically confirmed serious adverse events (SAEs) reported among 73 subjects with 6 such SAEs described as possibly or probably related to vaccination. Three fatal cases were reported and assessed as not related to vaccination. Two AESIs classified as convulsion were reported and assessed as not related to vaccination. Both AESIs occurred well outside the pre-specified 7 day risk window representing the likely timeframe of the occurrence of seizure following vaccination. CONCLUSIONS: The results of this study support the overall good safety profile of MF59 adjuvanted cell culture-derived influenza vaccine as administered in adults during the 2009-2010 H1N1 influenza pandemic. No concern is raised regarding the occurrence of AESIs.

Caracterización de los pacientes oncológicos que fallecieron durante los años 2010 y 2011 en la unidad de alivio del Dolor y cuidados paliativos de Oncomed, Santiago, Chile / Characterization of cancer patients who died during 2010 and 2011 in the unit of pain relief and palliative care of Oncomed, Santiago, Chile

Objetivo: Averiguar las principales características de los pacientes pertenecientes a la Unidad de Alivio del Dolor y Cuidados Paliativos de Oncomed que fallecieron entre los años 2010 y 2011.Método: Se realizó un estudio retrospectivo, descriptivo y transversal de los pacientes pertenecientes a la Unidad que fallecieron durante los años 2010 y 2011. Se seleccionaron enfermos con patología oncológica terminal y que tuvieron como mínimo 1 atención médica. Se analizaron las variables de edad, sexo, patología oncológica, ciudad de residencia, tiempo de permanencia en la unidad y lugar de fallecimiento. Resultados: De los 832 pacientes, 46,2 por ciento fueron de sexo femenino y 53,8 por ciento masculino. Las edades fluctuaron entre los 3 y los 103 años, encontrándose el mayor número de enfermos entre los 40 y 80 años. Las patologías más comunes fueron cáncer de pulmón, próstata y gástrico, en el sexo masculino; y mama, pulmón y páncreas, en el sexo femenino. El mayor número de pacientes se localizó en la XIII Región. El tiempo promedio de sobrevida de los pacientes fue de 140 días, fluctuando entre 1 y 1.819 días. Un 73,4 por ciento de los pacientes falleció en el domicilio y un 26,6 por ciento hospitalizado. Conclusión: El estudio realizado resulta interesante ya que nos aporta conocimiento de las características de los pacientes que se atienden en nuestra unidad y eso nos ayuda a mejorar la planificación y organización de los servicios sanitarios, orientándolos a dar una mejor respuesta a las necesidades y demandas de nuestros enfermos.

Objective: To identify the main characteristics of patients belonging to the unit for Pain Relief and Palliative Care of Oncomed, who died in 2010 and 2011.Method: A retrospective, descriptive and transversal study has been done of the patients treated in the unit, who died during years 2010 and 2011. Patients with terminal cancer pathology have been selected, that have had at least one medical attention. The variables analyzed were age, sex, oncologic pathology, city of residence, length of stay in the unit and place of death. Results: Of the 832 patients, 46.2 percent were female and 53.8 percent male. The ages ranged from 3 to 103 years old, finding the largest number of patients between 40 and 80. The most common diseases were lung, prostate and gastric cancers in males and breast, lung and pancreas cancers in women. The largest number of patients was located in the XII Region. The median survival time of patients was 140 days, ranging between 1 and 1819 days. 73.4 percent of patients died at home and 26.6 percent at hospitals. Conclusion: The study shows interesting results, providing knowledge of the characteristics of our patients, helping us to improve the planning and organization of health services, focusing them to meet in a better way the requirements and demands of our patients.