Efficient Strategies to Use ß-Cationic Porphyrin-Imidazolium Derivatives in the Photoinactivation of Methicillin-Resistant Staphylococcus aureus.

Bacterial resistance to antibiotics is a critical global health issue and the development of alternatives to conventional antibiotics is of the upmost relevance. Antimicrobial photodynamic therapy (aPDT) is considered a promising and innovative approach for the photoinactivation of microorganisms, particularly in cases where traditional antibiotics may be less effective due to resistance or other limitations. In this study, two ß-modified monocharged porphyrin-imidazolium derivatives were efficiently incorporated into polyvinylpyrrolidone (PVP) formulations and supported into graphitic carbon nitride materials. Both porphyrin-imidazolium derivatives displayed remarkable photostability and the ability to generate cytotoxic singlet oxygen. These properties, which have an important impact on achieving an efficient photodynamic effect, were not compromised after incorporation/immobilization. The prepared PVP-porphyrin formulations and the graphitic carbon nitride-based materials displayed excellent performance as photosensitizers to photoinactivate methicillin-resistant Staphylococcus aureus (MRSA) (99.9999% of bacteria) throughout the antimicrobial photodynamic therapy. In each matrix, the most rapid action against S. aureus was observed when using PS 2. The PVP-2 formulation needed 10 min of exposure to white light at 5.0 µm, while the graphitic carbon nitride hybrid GCNM-2 required 20 min at 25.0 µm to achieve a similar level of response. These findings suggest the potential of graphitic carbon nitride-porphyrinic hybrids to be used in the environmental or clinical fields, avoiding the use of organic solvents, and might allow for their recovery after treatment, improving their applicability for bacteria photoinactivation.

Photochemical and photocatalytic degradation of trans-resveratrol.

Photochemical and photocatalytic degradation of the emerging pollutant trans-resveratrol has been studied under different irradiation wavelengths and using different TiO2 catalysts. trans-Resveratrol was more easily degraded when irradiated using the whole spectral range (UV-Vis) rather than with UV and near-UV to visible irradiation. The main intermediate of trans-resveratrol phototransformation was identified as its isomer cis-resveratrol. Different TiO2 catalysts were used to carry out the photocatalytic degradation of trans-resveratrol. Catalysts properties such as crystallite dimensions, surface area and presence of hydroxy surface groups are shown to be crucial to the photocatalytic efficiency of the materials tested. From the point of view of trans-resveratrol abatement, the photocatalytic process was more efficient than the pure photochemical one resulting in higher degradation rates and higher organic content removal. Six photoproducts of trans-resveratrol phototransformation were identified mainly resulting from the attack of the hydroxyl radical to the organic molecule.

Photocatalytic oxidation of phenolic compounds by using a carbon nanotube-titanium dioxide composite catalyst.

A nanostructured multiwalled carbon nanotube (CNT) and titanium dioxide composite catalyst is prepared by a modified acid-catalyzed sol-gel method. Pure anatase TiO(2) and the CNT-TiO(2) composite are tested in the photocatalytic degradation of four para-substituted phenols: 4-chlorophenol, 4-aminophenol, 4-hydroxybenzoic acid and 4-nitrophenol. The effect of several operational parameters on the photoefficiency of the composite catalyst is studied by using 4-chlorophenol as model compound, namely catalyst loading, pH of the medium, hydrogen peroxide concentration, substrate concentration. A relationship between the Hammett constant of each para-substituted phenolic compound and its degradability by the photocatalysts is found. The effect of the carbon phase in the catalyst is ascribed to its photosensitizer action. A clear beneficial effect is observed for the degradation of 4-aminophenol and 4-chlorophenol. For the molecules with stronger electron-withdrawing (deactivating) groups, such as 4-hydroxybenzoic acid and 4-nitrophenol, no synergy effect is observed.

Anatase vs. rutile efficiency on the photocatalytic degradation of clofibric acid under near UV to visible irradiation.

Titanium dioxide (TiO(2)) powder, a semiconductor material typically used as a photocatalyst, is prepared following an acid-catalyzed sol-gel method starting from titanium isopropoxide. The xerogel calcination temperature is used to control surface and morphological properties of the material. Materials are extensively characterized by spectroscopic, micrographic and calorimetric techniques. The different TiO(2) catalysts are used in the visible-light-driven photocatalytic degradation of clofibric acid, a lipid regulator drug. The photoefficiency of TiO(2) catalysts, quantified in terms of kinetic rate constant, total organic carbon removal and initial quantum yield, increases with calcination temperature up to 673 K. A further increase in the calcination temperature leads to a decline in the photoefficiency of the catalysts, which is associated with the phase transformation from anatase to rutile concomitant with an increase in crystallite dimensions. The photochemical and photocatalytic oxidation of clofibric acid follows a pseudo-first order kinetic rate law. 4-Chlorophenol, isobutyric acid, hydroquinone, benzoquinone and 4-chlorocatechol are detected as main intermediates.