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1.
J Clin Oncol ; 39(10): 1150-1161, 2021 04 01.
Article in English | MEDLINE | ID: mdl-33555912

ABSTRACT

PURPOSE: Depression in post-treatment cancer survivors is common and can impair quality of life. CanDirect is a novel, telephone-delivered depression self-care intervention for cancer survivors. We conducted a randomized controlled superiority trial to compare CanDirect with usual care (UC) in this population. METHODS: Participants completing cancer treatment within the past 10 years who had mild-moderate depressive symptoms with or without major depression were recruited from clinical and community settings in Quebec and Ontario. Permuted block random assignment allocated participants to CanDirect plus UC or to UC alone. Assessments of depression severity (Center for Epidemiological Studies-Depression scale [CES-D]; primary outcome) and secondary outcomes health-related quality of life (Short Form Survey-12 mental and physical component summaries), anxiety symptoms (Hospital Anxiety and Depression Scale), activation (Patient Activation Measure), depression diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV), and health services (self-report) were conducted at baseline, as well as 3 and 6 months (primary time point). Analyses of outcomes were adjusted for covariates using linear regression and missing data by inverse probability weighting. RESULTS: Participants recruited between September 2016 and October 2018 were randomly assigned to CanDirect (n = 121) or UC (n = 124). Among 245 participants randomly assigned, 218 (89.0%) completed the primary outcome at 6 months. CanDirect participants reported less severe depressive symptoms on the CES-D than UC participants at 6 months, adjusted effect size (ES) 0.61 (95% CI, 0.33 to 0.88). CanDirect participants also had significantly greater quality of life, lower anxiety, more activation, and lower rates of depression diagnoses, compared with UC. Exploratory analysis suggested that sex was a modifier of the primary outcome (interaction term P value = .03); the intervention was less effective in men (ES, 0.12; 95% CI, -0.45 to 0.69). CONCLUSION: The findings suggest that CanDirect is an effective method of managing mild-moderate depression symptoms in cancer survivors.


Subject(s)
Cancer Survivors/psychology , Depressive Disorder, Major/therapy , Neoplasms/therapy , Psychotherapy/methods , Self Care/methods , Telephone , Adolescent , Adult , Aged , Anxiety/therapy , Depression/therapy , Female , Humans , Male , Middle Aged , Neoplasms/psychology , Ontario , Outcome Assessment, Health Care/methods , Outcome Assessment, Health Care/statistics & numerical data , Quality of Life , Quebec , Single-Blind Method , Surveys and Questionnaires , Young Adult
2.
Article in English | MEDLINE | ID: mdl-28984000

ABSTRACT

Supported self-care interventions are a low-intensity treatment for depression that has received little research attention in the cancer population. This is a phase II intervention only study to test the feasibility, acceptability and preliminary effectiveness of a depression self-care intervention for cancer patients who have completed their primary treatment and have moderate depressive symptoms. The self-care intervention was adapted from a successful model for people with chronic physical conditions, following focus groups with cancer care professionals and patients. The support was delivered by telephone by a trained lay coach who provided up to 8 weekly coaching contacts. A variety of recruitment methods were tested; those with the highest yield of eligible subjects per research staff time were electronic mailings to community support group members and social media posting. Sixty-eight people were contacted about the study over an 11-month period, of whom 34 (49%) were eligible; 32 were enrolled (94% recruitment rate); and 25 completed 2-month follow-up (78% retention). The mean severity of PHQ-9 depression decreased significantly from screening to 2 months (12.8 to 7.0, p < .0001). The intervention is a promising treatment option for cancer survivors, demonstrating sufficient effectiveness and feasibility to proceed with a phase III clinical trial.


Subject(s)
Cancer Survivors/psychology , Cognitive Behavioral Therapy/methods , Depression/therapy , Patient Education as Topic/methods , Self Care/methods , Adult , Depression/psychology , Feasibility Studies , Female , Focus Groups , Humans , Male , Middle Aged , Patient Acceptance of Health Care , Patient Health Questionnaire , Program Development , Telephone , Treatment Outcome
3.
Cytogenet Genome Res ; 148(2-3): 174-8, 2016.
Article in English | MEDLINE | ID: mdl-27251740

ABSTRACT

Deletions in the short arm of chromosome 12 are the rarest subtelomeric imbalances. Less than 20 patients have been reported to date, and their microdeletions were identified either by FISH or array-CGH without SNP data. Here, we report a patient with a 12p13.32pter mosaic deletion detected by chromosome microarray analysis with loss of heterozygosity (LOH) of the deleted segment in addition to the adjacent distal segment. LOH is indicative of a complex rearrangement, suggestive of mitotic microhomology-mediated break-induced replication.


Subject(s)
Loss of Heterozygosity/genetics , Mosaicism , Child , Child, Preschool , Chromosome Banding , Chromosome Deletion , Chromosomes, Human, Pair 12/genetics , DNA Replication , Face/abnormalities , Female , Humans , In Situ Hybridization, Fluorescence , Karyotype , Male
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