In phantom evaluation of targeting accuracy in MRI-based brain radiosurgery.

PURPOSE: To determine the targeting accuracy of brain radiosurgery when planning procedures employing different MRI and MRI + CT combinations are adopted. MATERIALS AND METHOD: A new phantom, the BrainTool, has been designed and realized to test image co-registration and targeting accuracy in a realistic anatomical situation. The phantom was created with a 3D printer and materials that mimic realistic brain MRI and CT contrast using a model extracted from a synthetic MRI study of a human brain. Eight markers distributed within the BrainTool provide for assessment of the accuracy of image registrations while two cavities that host an ionization chamber are used to perform targeting accuracy measurements with an iterative cross-scan method. Two procedures employing 1.5 T MRI-only or a combination of MRI (taken with 1.5 T or 3 T scanners) and CT to carry out Gamma Knife treatments were investigated. As distortions can impact targeting accuracy, MR images were preliminary evaluated to assess image deformation extent using GammaTool phantom. RESULTS: MR images taken with both scanners showed average and maximum distortion of 0.3 mm and 1 mm respectively. The marker distances in co-registered images resulted below 0.5 mm for both MRI scans. The targeting mismatches obtained were 0.8 mm, 1.0 mm and 1.2 mm for MRI-only and MRI + CT (1,5T and 3 T), respectively. CONCLUSIONS: Procedures using a combination of MR and CT images provide targeting accuracies comparable to those of MRI-only procedures. The BrainTool proved to be a suitable tool for carrying out co-registration and targeting accuracy of Gamma Knife brain radiosurgery treatments.

Quasi-distributed and wavelength selective addressing of optical micro-resonators based on long period fiber gratings.

A novel all-in-fiber method for coupling light to high-Q silica whispering gallery mode (WGM) optical micro-resonators is presented, which is based on a pair of long period fiber gratings (LPGs) written in the same silica fiber, along with a thick fiber taper (15-18 µm in waist) in between the LPGs. The proposed coupling structure is robust and can be replicated many times along the same fiber simply cascading LPGs with different bands. Typical Q-factors of the order of 10(8) and total coupling efficiency up to 60% were measured collecting the resonances of microspheres or microbubbles at the fiber end. This approach uniquely allows quasi-distributed and wavelength selective addressing of different micro-resonators along the same fiber.

Long period grating-based fiber coupler to whispering gallery mode resonators.

We present a new method for coupling light to high-Q silica whispering gallery mode resonators (WGMs) that is based on long period fiber gratings (LPGs) written in silica fibers. An LPG allows selective excitation of high-order azimuthally symmetric cladding modes in a fiber. Coupling of these cladding modes to WGMs in silica resonators is possible when partial tapering of the fiber is also implemented in order to reduce the optical field size and increase its external evanescent portion. Importantly, the taper size is about one order of magnitude larger than that of a standard fiber taper coupler. The suggested approach is therefore much more robust and useful especially for practical applications. We demonstrate coupling to high-Q silica microspheres and microbubbles detecting the transmission dip at the fiber output when crossing a resonance. An additional feature of this approach is that by cascading LPGs with different periods, a wavelength selective addressing of different resonators along the same fiber is also possible.

Optical frequency conversion in silica-whispering-gallery-mode microspherical resonators.

High quality factor whispering-gallery-mode microresonators are ideally suited for nonlinear optical interactions. We analyze, experimentally and theoretically, a variety of χ((3)) nonlinear interactions in silica microspheres, consisting of third harmonic generation and Raman assisted third order sum-frequency generation in the visible. A tunable, room temperature, cw multicolor emission in silica microspherical whispering-gallery-mode microresonators has been achieved by controlling the cavity mode dispersion and exciting nonequatorial modes for efficient frequency conversion.

High Q silica microbubble resonators fabricated by arc discharge.

Microbubble resonators combine the unique properties of whispering gallery mode resonators with the intrinsic capability of integrated microfluidics. Here an improved fabrication method of microbubble resonators is presented, based on the heating of a slightly pressurized capillary by a rotating arc discharge. Rotation of the electrodes, moved out of a fiber splicer, ensures a homogeneous distribution of the heat all over the capillary surface. The demonstrated microbubble resonators have Q factors up to 6×10(7) at 1550 nm. Microbubbles were filled with water and aqueous solutions of ethanol in order to test the refractive index sensing capabilities of such resonators, which also show a good temporal stability. The limit of detection of our microbubble resonator sensor is 10(-6) RIU.

Reverse mortgages.

Elders and their families are often caught in a financial bind when it comes to paying for much-needed home care services. Reverse mortgages may offer a solution to elderly home care clients who own their homes but have a limited income with which to maintain their independence.