ABSTRACT
The anti-granulocyte activity of serum from patients with B-cell chronic lymphocytic leukaemia (CLL) and other lymphoproliferative disorders was investigated. Granulocyte-binding IgG was measured in 34 patients with CLL, 13 patients with hairy cell leukaemia, one patient with prolymphocytic leukaemia, two patients with Sézary cell leukaemia, and seven patients with chronic T-cell lymphocytosis who had a predominance of circulating large granular lymphocytes. Anti-granulocyte activity was absent in CLL and its variants, but present in the majority of granulocytopenic patients with chronic T-cell lymphocytosis. In one of these patients, granulocytopenia was associated with complement-activating IgG granulocyte antibody. Thus, antibody-mediated granulocyte injury appears to be an unusual occurrence in chronic lymphocytic leukaemia, but is a frequent complication of chronic T-cell lymphocytosis.
Subject(s)
Autoantibodies/analysis , Granulocytes/immunology , Leukemia/immunology , Lymphoproliferative Disorders/immunology , Adult , Aged , Aged, 80 and over , Chronic Disease , Female , Humans , Immunoglobulin G/analysis , Leukemia, Hairy Cell/immunology , Leukemia, Lymphoid/immunology , Leukocyte Count , Male , Middle AgedSubject(s)
Autoantibodies/immunology , Autoimmune Diseases/immunology , Blood Platelets/immunology , Complement C3/immunology , Immunoglobulin M/immunology , Purpura, Thrombocytopenic/immunology , Antibodies, Monoclonal/analysis , Antibodies, Monoclonal/immunology , Autoantibodies/analysis , Autoimmune Diseases/therapy , Complement Activation , Humans , Immunoglobulin M/analysis , Male , Middle Aged , Paraproteinemias/complications , Paraproteinemias/immunology , Platelet Aggregation , Purpura, Thrombocytopenic/etiology , Purpura, Thrombocytopenic/therapy , SplenectomyABSTRACT
The presence of teardrop-shaped red cells in peripheral blood has traditionally been felt to reflect altered marrow architecture, namely myelofibrosis. We evaluated two patients with splenomegaly, moderately severe hemolytic anemia due to warm-reactive IgG anti-red cell autoantibody, and bone marrow erythroid hyperplasia without myelofibrosis. A striking predominance of teardrop-shaped red cells was noted upon examination of their blood films. Removal of a spleen containing extramedullary hematopoiesis in one and resolution of splenomegaly in the other were accompanied by disappearance of these cells. Our observations support a role for the spleen and for extramedullary hematopoiesis in the pathogenesis of this distinctive red cell morphologic abnormality.
