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Regulation of the lipidation of beta-secretase by statins.

Parsons, R B; Farrant, J K; Price, G C; Subramaniam, D; Austen, B M.

Biochem Soc Trans ; 35(Pt 3): 577-82, 2007 Jun.

Article in English | MEDLINE | ID: mdl-17511656

ABSTRACT

Statins inhibit the dimerization of beta-secretase [BACE (beta-site amyloid precursor protein-cleaving enzyme)] by inhibiting the lipidation of BACE and associated proteins. Our studies have demonstrated a clearly defined temporal sequence for these reactions in the assembly of the BACE complex, which may provide targets for the treatment of Alzheimer's disease.

Subject(s)

Amyloid Precursor Protein Secretases/metabolism , Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology , Alzheimer Disease/drug therapy , Alzheimer Disease/metabolism , Amyloid Precursor Protein Secretases/chemistry , Amyloid beta-Peptides/metabolism , Aspartic Acid Endopeptidases/metabolism , Cell Line , Cholesterol/metabolism , Dimerization , Humans , Lipid Metabolism/drug effects , Models, Biological

ABSTRACT

Subject(s)

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