APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sites.

Computational modelling of microbiome metabolism has proved instrumental to catalyse our understanding of diet-host-microbiome-disease interactions through the interrogation of mechanistic, strain- and molecule-resolved metabolic models. We present APOLLO, a resource of 247,092 human microbial genome-scale metabolic reconstructions spanning 19 phyla and accounting for microbial genomes from 34 countries, all age groups, and five body sites. We explored the metabolic potential of the reconstructed strains and developed a machine learning classifier able to predict with high accuracy the taxonomic strain assignments. We also built 14,451 sample-specific microbial community models, which could be stratified by body site, age, and disease states. Finally, we predicted faecal metabolites enriched or depleted in gut microbiomes of people with Crohn's disease, Parkinson disease, and undernourished children. APOLLO is compatible with the human whole-body models, and thus, provide unprecedented opportunities for systems-level modelling of personalised host-microbiome co-metabolism. APOLLO will be freely available under https://www.vmh.life/.

FPGA implementation of a sub-400ns 6G free-space optical wireless communications transmitter.

Future wireless networks are planned to service many applications with an Ultra Low-Latency (ULL) requirement. Numerous 6G systems have been proposed including more traditional electro-magnetic (EM) antenna transmissions and optical wireless communications (OWC). For extremely wide-band operation, the traditional approaches require digital pre-distortion and other processing techniques which, in turn, require more computational resources and processing times thus increasing latency. Alternatively, OWC has the potential for extremely wide bandwidths in 6G without the need for as much digital signal processing. In order to realise ULL performance, a minimum number of digital signal processing (DSP) blocks is required, as well as an optimal design of each of these. In this letter, we propose a DSP solution for ULL and peak to average power ratio (PAPR) reduction for OWC systems. Unitary checkerboard precoding - orthogonal frequency division multiplexing (UCP-OFDM) is chosen as the modulation scheme and has been implemented within a single digital block avoiding the use of standard OFDM which would otherwise require multiple digital blocks. Experimentally validated results successfully demonstrate a 2.21184 GSps wireless link at distances of up to 2m in noisy daylight settings. Bit error rates (BER) of 0 at root mean square (RMS) error vector magnitude (EVM) of 4.09% are achieved. A complete digital line-up of an OWC transmitter chain for this work contains only three core blocks and ULL of less than 400 ns.

Choledocholithiasis Can Present with Marked Transaminases Elevation: Systematic Review and Meta-Analysis.

BACKGROUND: Extreme transaminase elevation > 1000 international units per liter (IU/L) is typically caused by hepatocellular injury due to ischemia, drugs, or viral infection. Acute choledocholithiasis can also present with marked transaminase elevation mimicking severe hepatocellular injury, contrary to the presumed cholestatic pattern. METHODS: We searched PubMed/Medline, EMBASE, Cochrane Library, and Google Scholar for studies reporting the proportion of marked elevation of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 1000 IU/L in patients with common bile duct (CBD) stones. A proportion meta-analysis with a corresponding 95% confidence interval (CI) was used to pool the proportion of patients with extreme transaminase elevation. I2 was used to examine heterogeneity. We used CMA software utilizing a random effect model for statistical analysis. RESULTS: Three studies (n = 1328 patients) were included in our analysis. The reported frequency of ALT or AST > 1000 IU/L in choledocholithiasis patients ranged between 6 and 9.6%, with pooled frequency of 7.8% (95% CI 5.5-10.8%, I2 61%). The frequency of patients with ALT or AST > 500 IU/L was higher, ranging between 28 and 47%, with pooled frequency of 33.1% (95% CI 25.3-42%, I2 88%). CONCLUSION: This is the first meta-analysis to study prevalence of severe hepatocellular injury in patients with CBD stones. Results revealed that approximately one-third of patients with choledocholithiasis present with ALT or AST > 500 IU/L. Furthermore, levels > 1000 IU/L are not uncommon. An elaborate work-up for alternative etiologies of severe transaminase elevation is likely unwarranted in cases with clear evidence of choledocholithiasis.

Early Stopping Criterion for Recursive Least Squares Training of Behavioural Models.

The necessity of the rapid evolution of wireless communications, with continuously increasing demands for higher data rates and capacity Zheng (Big datadriven optimization for mobile networks toward 5g 30:44-51, 2016), is constantly augmenting the complexity of radio frequency (RF) transceiver architecture. A significant component in the configuration of such complex radio transceivers is the power amplifier(PA). Multiple distributed PAs are now common in proposed RF architectures. PAs exhibit non linear behaviour, causing signal distortion in transmission. Behavioural models offer a concise representation of a PAs characteristic performance which is extremely useful in simulating performance of multiple nonlinear power amplifiers. A considerable drawback with using the Recursive Least Squares (RLS) technique is that the instability of the coefficients during the training of the model. This manuscript provides a computationally efficient technique to detect the onset of instability during adaptive RLS training and subsequently to inform the decision to cease training of dynamic memory polynomial based behavioural models, to avoid the onset of instability. The proposed technique does not require modification of the RLS algorithm, merely an observation of the pre-exsisting autocorrelation function based update. This technique is experimentally validated using four different signal modulation schemes, LTE OFDM, 5G-NR, DVBS2X and WCDMA.

A Case of Acute Esophageal Necrosis.

Acute esophageal necrosis (AEN) is a rare condition that impacts the distal esophagus after a vascular insult. In this case report, we describe a patient with multiple comorbid conditions presenting with shock from gastroenteritis who subsequently developed AEN complicated by refractory strictures.

To avoid Hep B reactivation, screen before immunosuppression.

Universal HBV screening before immunosuppression is prudent and cost effective, even when local HBV prevalence is just 0.3%.

Minimal hardware Bluetooth tracking for long-term at-home elder supervision.

The ability to automatically detect the location of an elder within their own home is a significant enabler of remote elder supervision and interaction applications. This location information is typically generated via a myriad of sensors throughout the home environment. Even with high sensor redundancy, there are still situations where traditional elder monitoring systems are unable to resolve the location of the elder. This work develops a minimal infrastructure radio-frequency localisation system for long-term elder location tracking. An RFID room-labelling technique is employed and with it, the localisation system developed in this work is shown to exhibit superior performance to more traditional localisation systems in realistic long-term deployments.

Investigation into the mast cell stabilizing activity of nature-identical and synthetic indanones.

As part of an ongoing search for novel molecules with therapeutic potential we examined the mediator release inhibition activity of a number of indanones and their derivatives. The aldol condensation product 18 was approximately twice as potent as disodium cromoglycate as an inhibitor of compound 48/80-stimulated histamine release from rat peritoneal mast cells. The activity of this class of dimeric indanone compound is significantly higher than controls and may represent a new class of mast cell stabilizing agents. Compound 18 has been selected for further biological evaluation of its mast cell stabilization profile.