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1.
Int J Pediatr Otorhinolaryngol ; 116: 7-14, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30554711

ABSTRACT

OBJECTIVES: The main aim of the study was to examine the development and course of the facial nerve within fetal temporal bones from an anatomical and neuro-otological perspective. METHODS: The study was conducted on 32 temporal bones from obtained fetuses (7 females, 9 male), on a mean gestational age of 26.75 ±â€¯4.36 (range, 20-34) weeks from the collection of the Anatomy Department of Medicine Faculty. All the measurements were collected with a digital image analysis software. RESULTS: Neither male/female nor right/left significant differences were observed in relation with the algebraic data of the segment lengths and angles of the facial nerve (p > 0.05). Linear functions for meatal, labyrinthine, tympanic, and mastoid segment lengths of the facial nerve were calculated as: y = -1.206 + 0.200 × Age (weeks), y = -1.868 + 0.153 × Age (weeks), y = -2.327 + 0.325 × Age (weeks), and y = -1.507 + 0.246 × Age (weeks), respectively. In addition, linear functions for first and second genu angles were calculated as: y = 105.475-0.117 × Age (weeks) and y = 140.446-0.042 × Age (weeks), respectively. CONCLUSION: The regression equations and the scatter plot with increment curve, representing the growth dynamics of the facial nerve can be used for estimating its lengths and for understanding its development. The data suggest that there is a dramatic change transition from fetal life to the gathered data of adulthood in the length of meatal and mastoid segments as well as in the second genu angle; in addition, there is a partial change in the length of labyrinthine and tympanic segments as well as in the first genu angle.


Subject(s)
Facial Nerve/growth & development , Temporal Bone/anatomy & histology , Ear, Inner/anatomy & histology , Ear, Middle/anatomy & histology , Facial Nerve/anatomy & histology , Female , Fetus , Humans , Male , Mastoid/anatomy & histology
2.
J Int Adv Otol ; 14(2): 290-294, 2018 Aug.
Article in English | MEDLINE | ID: mdl-29460825

ABSTRACT

OBJECTIVE: There is still ongoing research on the relationship of arcuate eminence (AE) and superior semicircular canal (SSC). We aimed to evaluate the precision of predictability of SSC through the morphology of AE via radiological means. MATERIALS AND METHODS: This investigation is performed on 12 dry skulls belonging to Mersin University Medical Faculty department of anatomy. Computed tomography (CT) assessment is performed with 0.5-mm-thin sections temporal bone algorithm on dry skulls which were marked with fixated copper wire by scotch tapes on the most prominent part of the middle fossa floor assuming the location of AE. The data are reformatted on the workstation with vitrea 2.0. The distances of the determined three points including lateral (A), apical (B), and medial (C) of the SSC and the copper wire are measured radiologically. Also, the height between the most apical part of the SSC to the floor of the skullbase (H) is measured. The angles between the placed copper wires and the SSC (E) are calculated. The angle between SSC and the midpoint of the IAC (F) and SSC to the sulcus of the greater GSPN (G) were measured. The nearest distance was measured between the most posterior part of the SSC and the point marked by the perpendicular line drawn from the medial border of the petrous bone to the most posterior part of the internal auditory canal (IAC) (D). RESULTS: The right and left A, B, and C distances are 2.54+/- 2.75, 3.67+/-3.16, 5.85+/-3.77; 2.92+/-2.24, 3.68+/-2.93, 6.09+/-3.40, respectively. We could not find any statistical significance when the right A, B, and C distances were compared with the left values. Examination of the values revealed that C distance is greater than the A distance of the same side both for right (p=0.040) and left (p=0.022) measurements. The calculated left and right E angles are 30.313+/-12.838, and 35.558+/-18.437 degrees, respectively. Statistical significance was not found between the right and left angles. The right and left F, G angles were 53.17, 47.25; 93.58, 100.92 degrees; and D distances are 8.01, 8.13 millimeters, respectively. Statistical significance was not found when right and left E, F, G angles and D distances were compared. Among 12 left and 12 right sides, the copper wire was found to be nearly overlapping to SSC in two in the right and only one in the left. CONCLUSION: This study reveals that there is a great variability predicting the exact location of SSC through the prominence of AE. Complementary studies are needed with greater number of dry skulls and cadavers. Comparison of different hypothesis including the effect of temporal lobe sulcus is to be discussed to better enlighten the exact relationship of the aforementioned anatomical structures.


Subject(s)
Cranial Fossa, Middle/diagnostic imaging , Dissection/methods , Semicircular Canals/anatomy & histology , Algorithms , Cadaver , Cranial Fossa, Middle/anatomy & histology , Cranial Fossa, Middle/surgery , Humans , Petrous Bone/anatomy & histology , Petrous Bone/diagnostic imaging , Petrous Bone/surgery , Semicircular Canals/diagnostic imaging , Semicircular Canals/surgery , Temporal Bone/anatomy & histology , Temporal Bone/diagnostic imaging , Temporal Bone/surgery , Tomography, X-Ray Computed/methods
3.
Wounds ; 29(2): E10-E17, 2017 Feb.
Article in English | MEDLINE | ID: mdl-28272017

ABSTRACT

OBJECTIVE: The aim of this study was to investigate the probable effects of Hypericum perforatum (HP) on wound healing in diabetic rats. MATERIALS AND METHODS: Thirty-five male Wistar rats were divided evenly into 5 groups. Diabetes formation was induced by intraperitoneal streptozotocin (60 mg/kg) administration for groups 1 (HP extract in olive oil), 2 (HP extract in ethanol), 3 (povidone-iodine application), and 4 (diabetic rats without any applied medication); group 5 was the control. Dorsal dermoepidermal incision was performed on each rat after 48 hours. The aforementioned solutions were applied only to groups 1, 2, and 3; groups 4 and 5 did not receive solution applications. At the end of the 7-day period, the cutaneous tissue was resected from the center of the incised and sutured region and divided into 3 pieces for biomechanical, biochemical, and histopathological assessments. RESULTS: Ultimate stress and toughness significantly decreased in groups 3, 4, and 5 compared to group 1. There was a significant difference between groups 2 and 3 for the same parameters (P < .05). Compared with group 4, tissue malondialdehyde levels were found to be lower in the HP groups (P < .05). Histopathological evaluation revealed the fibroblast count was reduced considerably in the HP-applied rats compared with other groups (P < .05). CONCLUSION: Application of HP may be recommended as effective on wound healing in diabetic rats, but further investigation is needed to adapt the findings for clinical use.


Subject(s)
Diabetes Mellitus, Experimental/pathology , Hypericum/chemistry , Plant Extracts/pharmacology , Wound Healing/drug effects , Wounds and Injuries/pathology , Administration, Cutaneous , Animals , Anti-Infective Agents, Local/pharmacology , Disease Models, Animal , Male , Olive Oil/pharmacology , Rats , Rats, Wistar
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