PROSPECTIVE ANALYSIS OF THE EPIDEMIOLOGY OF CEREBROVASCULAR DISEASE AND STROKE AMONG THE ADULT POPULATION OF KYIV CITY, UKRAINE.

OBJECTIVE: The aim: We aimed to conduct a prospective analysis of the epidemiology of cerebrovascular disease and stroke among the adult population of Kyiv City, Ukraine the last 12 years. PATIENTS AND METHODS: Materials and methods: We analyzed sectoral statistical reports of cerebrovascular disease and stroke in Kyiv City for 2009-2020. The statistical method and the method of system approach were used in this study. RESULTS: Results: We established that during the last 12 years there was a decrease in the incidence of cerebrovascular disease and stroke among the adult population of Kyiv (reduction of 1.83 times (p <0.05) with t reliability criteria 26.89). However, the incidence remains high (476.62 per 100,000 population). At the same time, the prevalence of cerebrovascular isease remains stable, and among the working-age population tends to increase. The incidence of stroke indicates a positive trend (251.3 per 100,000 adult population of Kyiv in 2009 and 95.0 - in 2020, respectively). In particular, the number of primary registered strokes decreased 2.64 times (p ≤0.05) with a reliability criterion of 5.7 which is 1.94 (p≤0.05) times lower than in Ukraine generally. During the study period, 27,928 people died in Kyiv from a stroke. The mortality rate of stroke among the adult population in the city decreased from 96.14 per 100,000 in 2009 to 57.17 in 2020. This significant decline occurred over the past two years. CONCLUSION: Conclusions: A significant reduction in the incidence of cerebrovascular disease and stroke in the adult population of Kyiv during the last 12 years has been established. This might be caused by increased stroke prevention work, provided to the city population, and by a higher level of availability and quality of medical care in recent years.

GLYCOGEN STORAGE DISEASE TYPE II: A NARRATIVE LITERATURE REVIEW AND A CASE REPORT OF LATE-ONSET POMPE DISEASE IN A YOUNG WHITE CHILD.

At all ages, skeletal muscle weakness characterizes Pompe disease, causes mobility problems and affects the respiratory system. We aimed to provide a narrative review of terminology, etiology, epidemiology, clinical manifestations, complications, and prognosis of Pompe disease, supported with a clinical case presentation. The clinical manifestation and complications of Pompe disease are illustrated with the clinical case presentation of a late-onset form in a white child. A comprehensive electronic literature search was performed on Ovid, Google Scholar, Scopus, PubMed, Embase, Cochrane Database, and World Health Organization databases to identify the articles that discussed Pompe disease.

ACUTE TRANSVERSE MYELITIS AS A NEUROLOGICAL COMPLICATION OF COVID-19: A CASE REPORT.

We aim to report a COVID-19-related case of acute myelitis that has not been associated with any other viral infections. A 23-year-old student was admitted to the hospital within a month from the time of loss of smell and taste with features of acute-onset non-compressive myelitis with paresthesia on both sides from the Th9 level. Complex neurological, clinical, laboratory, and neuroimaging examination was performed within 24 hours of admission. MRI of the spine showed a segment of increased T2 signal in the center of the spinal cord at Th11-Th12. Elevated protein level and lymphocytic pleocytosis were detected in the cerebrospinal fluid. A serologic blood test for SARS-CoV-2 showed recent infection. PCR for other viral infections was negative. The patient was treated with injectable steroids and showed full recovery. Specific neurological features of acute myelitis associated with COVID-19 were reported, described, and analyzed. Patient was treated and recovered.

CLINICAL AND IMAGING FEATURES OF LACUNAR AND NON-LACUNAR SUBTYPES OF ISCHEMIC POSTERIOR CIRCULATION STROKE.

OBJECTIVE: The aim: The purpose of this study is to determine clinical and imaging features of etiological subtypes of posterior circulation stroke in a prospective hospital-based cohort study. PATIENTS AND METHODS: Materials and methods: We prospectively recruited 120 acute posterior circulation stroke patients, admitted to the Neurological Center of the University Hospital (Oleksandrivska Clinical Hospital) in Kyiv, Ukraine, within 6 to 24 hours from the onset of the stroke symptoms. Comprehensive neurological, clinical, laboratory, ultrasound, and imaging examination was performed on all patients. RESULTS: Results: MRI/CT-proven etiological subtypes of ischemic posterior circulation stroke were defined - atherothrombotic (n = 59), cardioembolic (n = 24), lacunar (n = 27), and definitively indeterminate (n = 7). Two main study groups were formed - lacunar (n = 27) and non-lacunar (n = 90) subtypes of posterior circulation stroke. CONCLUSION: Conclusions: Specific clinical and imaging features of etiological subtypes of posterior circulation stroke were determined, analyzed, compared, and described.

Clinical syndromes of the thalamic stroke in the classical vascular territories: a prospective hospital-based cohort study.

OBJECTIVE: The aim: We aimed to determine, describe, and analyze the clinical and neuroimaging features of vascular syndromes of acute thalamic stroke in the classical vascular territories in a prospective hospital-based cohort study. PATIENTS AND METHODS: Materials and methods: We have prospectively recruited 319 acute stroke patients, admitted to the Neurological Center at an academic hospital (Oleksandrivska Clinical Hospital) in Kyiv, Ukraine. Complex neurological, clinical, laboratory, ultrasound, and neuroimaging examinations were performed to all study patients within 24 hours since the symptoms onset. RESULTS: Results: MRI/CT-proven thalamic stroke was diagnosed in 34 (10.6%) out of 319 patients, forming a study group. Twenty-two out of 34 patients (average age 61.9 ± 10.2 years) were diagnosed with an acute isolated ischemic thalamic stroke, and 12 patients (average age 59.0 ± 9.6 years) were diagnosed with an acute thalamic hemorrhage. CONCLUSION: Conclusions: Specific neurological features of clinical vascular syndromes of acute thalamic stroke in the classical vascular territories were analyzed, compared, and described.