ABSTRACT
Acute localized exanthematous pustulosis (ALEP) is a rare disease characterized by the acute onset of multiple localized non-follicular, pinhead-sized pustules. ALEP is considered a localized form of acute generalized exanthematous pustulosis but its pathogeny is not well identified. We performed a systematic review of the literature of all publications regarding ALEP cases using the term "acute localized exanthematous pustulosis," to provide an update on this disease and its management. Results and conclusion ALEP is an uncommon skin condition attributed primarily to a hypersensitivity reaction to a systemic drug (classical or herbal); though a contact mechanism has been reported. It may be misdiagnosed as infectious or inflammatory disease but the clinico-pathological correlation in addition to the rapid response to withdrawal of the culprit agent supports this diagnosis. The pathogenesis of ALEP is still unclear, and there are no standardized treatment guidelines to manage this disease. Both AGEP and ALEP have a good prognosis if an early diagnosis is made.
Subject(s)
Acute Generalized Exanthematous Pustulosis , Acute Generalized Exanthematous Pustulosis/diagnosis , Acute Generalized Exanthematous Pustulosis/etiology , Acute Generalized Exanthematous Pustulosis/therapy , HumansABSTRACT
Nephrogenic systemic fibrosis is a rare entity occurred in patients with renal failure. It is related to toxicity to gadolinium, which is used as a contrast agent in magnetic resonance imaging. Clinic manifestations are variable. They begin by a thickening of the skin in the lower limbs and extending to the upper limbs. We report a new case of nephrogenic systemic fibrosis where cutaneous lesions begin in the upper right limb as indurated and ulcerated nodules. The diagnosis is histological.
Subject(s)
Contrast Media/adverse effects , Gadolinium/adverse effects , Nephrogenic Fibrosing Dermopathy/diagnosis , Female , Humans , Middle Aged , Nephrogenic Fibrosing Dermopathy/chemically induced , Skin/pathologySubject(s)
Breast Neoplasms, Male/pathology , Melanoma/pathology , Paget's Disease, Mammary/pathology , Breast Neoplasms, Male/diagnostic imaging , Breast Neoplasms, Male/surgery , Combined Modality Therapy , Diagnosis, Differential , Humans , Male , Mastectomy, Radical , Melanoma/diagnostic imaging , Melanoma/surgery , Middle Aged , Paget's Disease, Mammary/diagnostic imaging , Paget's Disease, Mammary/surgery , Radiography , Treatment OutcomeABSTRACT
Dermatofibrosarcoma protuberans of Darier and Ferrand is a mesenchymatous skin tumor of intermediate malignant potential, characterised by slow growth, local malignancy and a high rate of recurrence. It is a rare tumor, accounting for approximately 0.1% to 0.18% of all malignant skin tumors. Peak incidence of the disease is between 20 to 40 years of age. We report a retrospective study of 28 cases of dermatofibrosarcoma protuberans. We reviewed the clinical features, histopathological and immunohistochemical aspects of this tumor.
