ABSTRACT
The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia (CIN). Data were collected in a case-control study for 60 patients with CIN in biopsy and 85 control subjects with normal colposcopy and biopsy. Serum antibodies to C trachomatis were associated with an increased risk for CIN [odds ratio (OR) = 7.3; 95% confidence interval (CI) 1.5-35.2)]. There was also a significant association between presence of inclusion bodies for C. trachomatis and CIN (OR = 5.5; 95% CI 2.4-12.4). These results indicate a strong association between CIN and chlamydial cervicitis.
Subject(s)
Chlamydia Infections/complications , Chlamydia trachomatis , Uterine Cervical Dysplasia/microbiology , Uterine Cervical Neoplasms/microbiology , Vaginal Diseases/complications , Adult , Aged , Biopsy , Case-Control Studies , Chi-Square Distribution , Chlamydia Infections/diagnosis , Chlamydia Infections/epidemiology , Colposcopy , Female , Humans , Iran/epidemiology , Middle Aged , Risk Factors , Surveys and Questionnaires , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/epidemiology , Vaginal Diseases/diagnosis , Vaginal Diseases/epidemiology , Uterine Cervical Dysplasia/diagnosis , Uterine Cervical Dysplasia/epidemiologyABSTRACT
The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia [CIN]. Data were collected in a case-control study for 60 patients with CIN in biopsy and 85 control subjects with normal colposcopy and biopsy. Serum antibodies to C. trachomatis were associated with an increased risk for CIN [odds ratio [OR] = 7.3; 95% confidence interval [CI] 1.5-35.2]]. There was also a significant association between presence of inclusion bodies for C. trachomatis and CIN [OR = 5.5; 95% CI 2.4-12.4]. These results indicate a strong association between CIN and chlamydial cervicitis
Subject(s)
Chlamydia trachomatis , Biopsy , Case-Control Studies , Retrospective Studies , Uterine Cervical DysplasiaABSTRACT
BACKGROUND: Direct stenting without balloon dilatation may reduce procedural costs and duration, and hypothetically, the restenosis rate. This study was designed to compare the in-hospital and long-term outcomes of direct stenting (DS) versus stenting after pre-dilatation (PS) in our routine clinical practice. METHODS: The 1 603 patients treated with stenting for single coronary lesions were enrolled into a prospective registry. Patients with acute myocardial infarction (MI) within the preceding 48 hours, and those with highly calcified lesions, total occlusions, or a lesion in a saphenous graft were excluded. The baseline, angiographic and procedural data, in-hospital outcomes and follow-up data were recorded in our database and analysed with appropriate statistical methods. RESULTS: Eight hundred and fifty-seven patients (53.5%) were treated with DS and 746 (46.5%) underwent PS. In the DS group, lesions were shorter in length, larger in diameter and had lower pre-procedural diameter stenosis. Type C and diffuse lesions and drug-eluting stents were found less often (p < 0.001). With univariate analysis, dissection and non- Q-wave MI occurred less frequently in this group (0.2 and 0.6% vs 3.9 and 2.1%, p < 0.001 and p = 0.01, respectively). However, the cumulative major adverse cardiac events (MACE) did not differ significantly (4.9 vs 4.6%, p = 0.79). With multivariate analysis, direct stenting reduced the risk of dissection (OR = 0.07, 95% CI: 0.01-0.33, but neither the cumulative endpoint of MACE (OR = 1.1, 95% CI = 0.58- 2.11, p = 0.7) nor its constructing components were different between the groups. CONCLUSIONS: Direct stenting in the real world has at least similar long-term outcomes in patients treated with stenting after pre-dilatation, and is associated with lower dissection rates.
Subject(s)
Angioplasty, Balloon, Coronary/adverse effects , Cardiovascular Diseases/etiology , Coronary Stenosis/therapy , Stents , Adult , Aged , Aged, 80 and over , Angioplasty, Balloon, Coronary/instrumentation , Angioplasty, Balloon, Coronary/mortality , Cardiovascular Diseases/mortality , Coronary Angiography , Coronary Stenosis/diagnostic imaging , Coronary Stenosis/mortality , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Odds Ratio , Platelet Aggregation Inhibitors/therapeutic use , Prospective Studies , Registries , Risk Assessment , Time Factors , Treatment OutcomeABSTRACT
Background : Direct stenting without balloon dilatation may reduce procedural costs and duration; and hypothetically; the restenosis rate. This study was designed to compare the in-hospital and long-term outcomes of direct stenting (DS) versus stenting after pre-dilatation (PS) in our routine clinical practice. Methods : The 1 603 patients treated with stenting for single coronary lesions were enrolled into a prospective registry. Patients with acute myocardial infarction (MI) within the preceding 48 hours; and those with highly calcified lesions; total occlusions; or a lesion in a saphenous graft were excluded. The baseline; angiographic and procedural data; in-hospital outcomes and follow-up data were recorded in our database and analysed with appropriate statistical methods. Results : Eight hundred and fifty-seven patients (53.5) were treated with DS and 746 (46.5) underwent PS. In the DS group; lesions were shorter in length; larger in diameter and had lower pre-procedural diameter stenosis. Type C and diffuse lesions and drug-eluting stents were found less often (p 0.001). With univariate analysis; dissection and non-Q-wave MI occurred less frequently in this group (0.2 and 0.6vs 3.9 and 2.1; p 0.001 and p ; p = 0.79). With multivariate analysis; direct stenting reduced the risk of dissection (OR = 0.07; 95CI: 0.01-0.33; but neither the cumulative endpoint of MACE (OR = 1.1; 95CI = 0.58-2.11; p = 0.7) nor its constructing components were different between the groups. Conclusions : Direct stenting in the real world has at least similar long-term outcomes in patients treated with stenting after pre-dilatation; and is associated with lower dissection rates
