Thanatomicrobiome in forensic medicine.

The circumstances of death and the estimation of the post-mortem interval (PMI) are often a great challenge for scientific and judicial investigators, especially when some time has elapsed since death. Several techniques are used; nevertheless, each presents its own limitations. In the quest for new techniques that are more reliable or at least complementary to those existing and sometimes less expensive, researchers have in recent years turned toward exploring the dynamics of the different microbial communities of a corpse according to their different stages of decomposition. This article summarizes the various works done in the field and shows the different sources of microorganisms in the different parts of the human corpse and their potential interest in the field of forensic medicine.

Successful and Safe Treatment With 177Lu-DOTATATE (Lutathera) of Progressive Metastatic Pancreatic Neuroendocrine Tumor Under Hemodialysis.

Lu-DOTATATE is an effective treatment for inoperable metastatic well-differentiated pancreatic neuroendocrine tumors. There are no guidelines for patients with terminal renal failure. We present the case of a 74-year-old woman who received different lines of treatment: analogs of somatostatin, chemotherapy, a first series of peptide receptor radionuclide therapy (PRRT), and finally chemoembolization. Because of persistent hepatic progression, a safe and successful administration of 4 cycles of a second series of PRRT under hemodialysis was administered. Patient was in scintigraphic complete remission at 12 months with normal hematological parameters at 12 and 30 months after PRRT.